A Semi-Parametric Quantile Function Estimator for Use in Bootstrap Estimation Procedures

In this note we develop a new quantile function estimator called the tail extrapolation quantile function estimator. The estimator behaves asymptotically exactly the same as the standard linear interpolation estimator. For finite samples there is small correction towards estimating the extreme quantiles. We illustrate that by employing this new estimator we can greatly improve the coverage probabilities of the standard bootstrap percentile confidence intervals. The method does not reqiure complicated calculations and hence it should appeal to the statistical practitioner.     

A weighted Harrell–Davis distance test with applications to censored data

Consider the standard treatment-control model with a time-to-event endpoint. We propose a novel interpretable test statistic from a quantile function point of view. The large sample consistency of our estimator is proven for fixed bandwidth values theoretically and validated empirically. A Monte Carlo simulation study also shows that given small sample sizes, utilization of a tuning parameter through the application of a smooth quantile function estimator shows an improvement in efficiency in terms of the MSE when compared to direct application of classic Kaplan–Meier survival function estimator. The procedure is finally illustrated via an application to epithelial ovarian cancer data.     

An Investigation of Quantile Function Estimators Relative to Quantile Confidence Interval Coverage

In this article, we investigate the limitations of traditional quantile function estimators and introduce a new class of quantile function estimators, namely, the semi-parametric tail-extrapolated quantile estimators, which has excellent performance for estimating the extreme tails with finite sample sizes. The smoothed bootstrap and direct density estimation via the characteristic function methods are developed for the estimation of confidence intervals. Through a comprehensive simulation study to compare the confidence interval estimations of various quantile estimators, we discuss the preferred quantile estimator in conjunction with the confidence interval estimation method to use under different circumstances. Data examples are given to illustrate the superiority of the semi-parametric tail-extrapolated quantile estimators. The new class of quantile estimators is obtained by slight modification of traditional quantile estimators, and therefore, should be specifically appealing to researchers in estimating the extreme tails.     

An exact density-based empirical likelihood ratio test for paired data

The Wilcoxon rank-sum test and its variants are historically well-known to be very powerful nonparametric decision rules for testing no location difference between two groups given paired data versus a shift alternative. In this title, we propose a new alternative empirical likelihood (EL) ratio approach for testing the equality of marginal distributions given that sampling is from a continuous bivariate population. We show that in various shift alternative scenarios the proposed exact test is superior to the classic nonparametric procedures, which may break down completely or are frequently inferior to the density-based EL ratio test. This is particularly true in the cases where there is a nonconstant shift under the alternative or the data distributions are skewed. An extensive Monte Carlo study shows that the proposed test has excellent operating characteristics. We apply the density-based EL ratio test to analyze real data from two medical studies.     

Modifications of the Empirical Likelihood Interval Estimation with Improved Coverage Probabilities

The empirical likelihood (EL) technique has been well addressed in both the theoretical and applied literature in the context of powerful nonparametric statistical methods for testing and interval estimations. A nonparametric version of Wilks theorem (Wilks, 1938 Wilks , S. S. ( 1938 ). The large-sample distribution of the likelihood ratio for testing composite hypotheses . Annals of Mathematical Statistics 9 : 60 – 62 .[Crossref] , [Google Scholar]) can usually provide an asymptotic evaluation of the Type I error of EL ratio-type tests. In this article, we examine the performance of this asymptotic result when the EL is based on finite samples that are from various distributions. In the context of the Type I error control, we show that the classical EL procedure and the Student's t-test have asymptotically a similar structure. Thus, we conclude that modifications of t-type tests can be adopted to improve the EL ratio test. We propose the application of the Chen (1995 Chen , L. ( 1995 ). Testing the mean of skewed distributions . Journal of the American Statistical Association 90 : 767 – 772 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) t-test modification to the EL ratio test. We display that the Chen approach leads to a location change of observed data whereas the classical Bartlett method is known to be a scale correction of the data distribution. Finally, we modify the EL ratio test via both the Chen and Bartlett corrections. We support our argument with theoretical proofs as well as a Monte Carlo study. A real data example studies the proposed approach in practice.     

A linear model-based test for the heterogeneity of conditional correlations

Current methods of testing the equality of conditional correlations of bivariate data on a third variable of interest (covariate) are limited due to discretizing of the covariate when it is continuous. In this study, we propose a linear model approach for estimation and hypothesis testing of the Pearson correlation coefficient, where the correlation itself can be modeled as a function of continuous covariates. The restricted maximum likelihood method is applied for parameter estimation, and the corrected likelihood ratio test is performed for hypothesis testing. This approach allows for flexible and robust inference and prediction of the conditional correlations based on the linear model. Simulation studies show that the proposed method is statistically more powerful and more flexible in accommodating complex covariate patterns than the existing methods. In addition, we illustrate the approach by analyzing the correlation between the physical component summary and the mental component summary of the MOS SF-36 form across a fair number of covariates in the national survey data.     

Two‐sample empirical likelihood ratio tests for medians in application to biomarker evaluations

The median is a commonly used parameter to characterize biomarker data. In particular, with two vastly different underlying distributions, comparing medians provides different information than comparing means; however, very few tests for medians are available. We propose a series of two‐sample median‐specific tests using empirical likelihood methodology and investigate their properties. We present the technical details of incorporating the relevant constraints into the empirical likelihood function for in‐depth median testing. An extensive Monte Carlo study shows that the proposed tests have excellent operating characteristics even under unfavourable occasions such as non‐exchangeability under the null hypothesis. We apply the proposed methods to analyze biomarker data from Western blot analysis to compare normal cells with bronchial epithelial cells from a case–control study. The Canadian Journal of Statistics 39: 671–689; 2011. © 2011 Statistical Society of Canada     

A Smooth Bootstrap Procedure towards Deriving Confidence Intervals for the Relative Risk

Given a pair of sample estimators of two independent proportions, bootstrap methods are a common strategy towards deriving the associated confidence interval for the relative risk. We develop a new smooth bootstrap procedure, which generates pseudo-samples from a continuous quantile function. Under a variety of settings, our simulation studies show that our method possesses a better or equal performance in comparison with asymptotic theory based and existing bootstrap methods, particularly for heavily unbalanced data in terms of coverage probability and power. We illustrate our procedure as applied to several published data sets.