Large Deviation Results for Statistics of Short- and Long-memory Gaussian Processes

This paper discusses the large deviation principle of several important statistics for short- and long-memory Gaussian processes. First, large deviation theorems for the log-likelihood ratio and quadratic forms for a short-memory Gaussian process with mean function are proved. Their asymptotics are described by the large deviation rate functions. Since they are complicated, they are numerically evaluated and illustrated using the Maple V system (Char et al ., 1991a,b). Second, the large deviation theorem of the log-likelihood ratio statistic for a long-memory Gaussian process with constant mean is proved. The asymptotics of the long-memory case differ greatly from those of the short-memory case. The maximum likelihood estimator of a spectral parameter for a short-memory Gaussian stationary process is asymptotically efficient in the sense of Bahadur.     

On improving convergence rate of Bernstein polynomial density estimator

This paper is concerned with the Bernstein estimator [Vitale, R.A. (1975), ‘A Bernstein Polynomial Approach to Density Function Estimation’, in Statistical Inference and Related Topics, ed. M.L. Puri, 2, New York: Academic Press, pp. 87–99] to estimate a density with support [0, 1]. One of the major contributions of this paper is an application of a multiplicative bias correction [Terrell, G.R., and Scott, D.W. (1980), ‘On Improving Convergence Rates for Nonnegative Kernel Density Estimators’, The Annals of Statistics, 8, 1160–1163], which was originally developed for the standard kernel estimator. Moreover, the renormalised multiplicative bias corrected Bernstein estimator is studied rigorously. The mean squared error (MSE) in the interior and mean integrated squared error of the resulting bias corrected Bernstein estimators as well as the additive bias corrected Bernstein estimator [Leblanc, A. (2010), ‘A Bias-reduced Approach to Density Estimation Using Bernstein Polynomials’, Journal of Nonparametric Statistics, 22, 459–475] are shown to be O(n^?8/9) when the underlying density has a fourth-order derivative, where n is the sample size. The condition under which the MSE near the boundary is O(n^?8/9) is also discussed. Finally, numerical studies based on both simulated and real data sets are presented.     

Salvage therapy trial for erectile dysfunction using phosphodiesterase type 5 inhibitors and vitamin E: Preliminary report

We report our initial experience with salvage therapy for low responders to PDE-5 inhibitors by adding vitamin E. Of 89 patients with ED who visited our clinic between January 2004 to August 2006, 9 were unable to obtain a full response to a PDE-5 inhibitor and included in the present study. After providing informed consent, each was given 300 mg per day of α-tocophenol at least 1 month and completed IIEF-5 questionnaires to assess its efficacy while also taking a PDE-5 inhibitor. With α-tocophenol administration, the average IIEF-5 score increased from 13.8 ± 3.2 to 17.1 ± 3.6. Four of seven patients who completed the questionnaire each time showed improved IIEF-5 scores, with a maximum elevation of 9 points. Further, eight of the nine patients experienced favourable subjective changes, the majority being increased penile rigidity. The present clinical trial results are, to our knowledge, the first known to show the effects of vitamin E for enhancing the efficacy of a PDE-5 inhibitor.     

Second-Order Powers of a Class of Tests in the Presence of a Nuisance Parameter

The second-order local powers of a broad class of asymptotic chi-squared tests are considered in a composite case where both the parameter of interest and the nuisance parameter are possibly multidimensional for which no assumption has been made regarding global parametric orthogonality or curved exponentiality. The main result is that the second-order (point-by-point) local power identity holds if approximate third cumulants of a square-root version of the (modified) test statistic in the class vanish up to the second-order, which is an extension of Kakizawa (2010a Kakizawa , Y. ( 2010a ). Second-order power comparison of tests . Commun. Statist. Theor. Meth. 39 : 1424 – 1436 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) in the absence of the nuisance parameter. It is also shown that in the presence of the nuisance parameter, such a third cumulant condition does not always imply the second-order local unbiasedness of the resulting test. Then, the adjusted likelihood ratio test by Mukerjee (1993b Mukerjee , R. ( 1993b ). An extension of the conditional likelihood ratio test to the general multiparameter case . Ann. Inst. Statist. Math. 45 : 759 – 771 .[Crossref], [Web of Science ®] , [Google Scholar]) can be interpreted as the second-order local unbiased modification after applying the third cumulant condition.     

Limiting bias-reduced Amoroso kernel density estimators for non-negative data

The Amoroso kernel density estimator (Igarashi and Kakizawa 2017 Igarashi, G., and Y. Kakizawa. 2017. Amoroso kernel density estimation for nonnegative data and its bias reduction. Department of Policy and Planning Sciences Discussion Paper Series No. 1345, University of Tsukuba. [Google Scholar]) for non-negative data is boundary-bias-free and has the mean integrated squared error (MISE) of order O(n^{? 4/5}), where n is the sample size. In this paper, we construct a linear combination of the Amoroso kernel density estimator and its derivative with respect to the smoothing parameter. Also, we propose a related multiplicative estimator. We show that the MISEs of these bias-reduced estimators achieve the convergence rates n^{? 8/9}, if the underlying density is four times continuously differentiable. We illustrate the finite sample performance of the proposed estimators, through the simulations.