The state of social capital: Bringing back in power,politics, and history

Theory and Society -     

Changing times in pharmaceutical statistics: 2000‐2020

In a previous paper we considered how pharmaceutical statistics had changed between 1980 and 2000. In this paper we go on to consider some of the likely influences and changes in the world of pharmaceutical statistics over the next twenty years. Statistical research by pharmaceutical companies is supported, although its direct value in boosting company profits is challenged. The duality between fraud and conflict of interest is explored, particularly with regard to data and safety monitoring boards. Political correctness within clinical trials and (allegedly) better patient‐oriented outcomes is questioned and the whole notion of intention‐to‐treat and per‐protocol analyses is rejected in favour of pragmatic trials and explanatory trials. The dominance of SAS software within the industry is explored and the possibility for change considered. Finally, whilst the future of pharmaceutical companies is not addressed, the impact of future mergers, collaborations and take‐overs between clinical research organizations is considered. Copyright © 2002 John Wiley & Sons, Ltd.     

Immigrants and alien workers

VII. Conclusion The number of immigrants now coming to the United States is proportionally only a fraction of the number that came in earlier years, and there is nothing in those numbers to suggest a difficult absorption burden. Immigrants, both legal and illegal, more than pay for the services they use with the taxes they pay, leaving a considerable net surplus that benefits American citizens. Immigrants raise productivity and do not cause an observable amount of unemployment of citizens. Admitting far more immigrants into the country than the law now allows would have positive effects on the incomes of citizens, and would enhance the continuing vitality of the United States.     

Young People who have Sexually Abused: What do they (and their parents) want from Professionals?

This article presents the findings of a small scale qualitative study of user perspectives in the adolescent sexual aggression field. Twenty four service users who had received intervention from nine different specialist providers completed a structured questionnaire about their experiences of professional involvement. Both young people who had sexually abused and parents identified the kinds of professional intervention which they found useful, as well as practices that they experienced as unhelpful. Young people and their families alike were found to value supportive interventions which gave them an opportunity to gain insight into the nature of sexual abuse as well to address their own feelings about their problems.     

House price indices

The new FT House Price Index aims to end the confusion that arises from the current plethora of indices. Simon Briscoe examines these various indices and explains the methodology behind the FT Index.     

Videology: Video-Games as Postmodern Sites/Sights of Ideological Reproduction

As new technologies, video-games are becoming increasingly popular among today's pre-teens and teenagers. Relying on systematic observation of videogames found in public arcades, participation in them, and engagement with the relevant literature, I explore eight central assumptions of “videology”: the ideology which organizes these games. While suggesting that these assumptions articulate and exaggerate problematic ideological themes, I also explore the relationship between videology and a postmodern culture or moment.     

What to Do at Low Doses: A Bounding Approach for Economic Analysis

To quantify the health benefits of environmental policies, economists generally require estimates of the reduced probability of illness or death. For policies that reduce exposure to carcinogenic substances, these estimates traditionally have been obtained through the linear extrapolation of experimental dose-response data to low-exposure scenarios as described in the U.S. Environmental Protection Agency's Guidelines for Carcinogen Risk Assessment (1986). In response to evolving scientific knowledge, EPA proposed revisions to the guidelines in 1996. Under the proposed revisions, dose-response relationships would not be estimated for carcinogens thought to exhibit nonlinear modes of action. Such a change in cancer-risk assessment methods and outputs will likely have serious consequences for how benefit-cost analyses of policies aimed at reducing cancer risks are conducted. Any tendency for reduced quantification of effects in environmental risk assessments, such as those contemplated in the revisions to EPA's cancer-risk assessment guidelines, impedes the ability of economic analysts to respond to increasing calls for benefit-cost analysis. This article examines the implications for benefit-cost analysis of carcinogenic exposures of the proposed changes to the 1986 Guidelines and proposes an approach for bounding dose-response relationships when no biologically based models are available. In spite of the more limited quantitative information provided in a carcinogen risk assessment under the proposed revisions to the guidelines, we argue that reasonable bounds on dose-response relationships can be estimated for low-level exposures to nonlinear carcinogens. This approach yields estimates of reduced illness for use in a benefit-cost analysis while incorporating evidence of nonlinearities in the dose-response relationship. As an illustration, the bounding approach is applied to the case of chloroform exposure.     

Valuation of childhood risk reduction: the importance of age, risk preferences, and perspective.

This article explores two problems analysts face in determining how to estimate values for children's health and safety risk reductions. The first addresses the question: Do willingness‐to‐pay estimates for health risk changes differ across children and adults and, if so, how? To answer this question, the article first examines the potential effects of age and risk preferences on willingness to pay. A summary of the literature reporting empirical evidence of differences between willingness to pay for adult health and safety risk reductions and willingness to pay for health and safety risk reductions in children is also provided. The second dimension of the problem is a more fundamental issue: Whose perspective is relevant when valuing children's health effects—society's, children's, adults‐as‐children, or parents'? Each perspective is considered, followed ultimately by the conclusion that adopting a parental perspective through an intrahousehold allocation model seems closest to meeting the needs of the estimation problem at hand. A policy example in which the choice of perspective affects the outcome of a regulatory benefit‐cost analysis rounds out the article and emphasizes the importance of perspective.