Heterogeneity in treatment effects across diverse populations

Differences in patient characteristics, including age, sex, and race influence the safety and effectiveness of drugs, biologic products, and medical devices. Here we provide a summary of the topics discussed during the opening panel at the 2018 Johns Hopkins Center for Excellence in Regulatory Science and Innovation symposium on Assessing and Communicating Heterogeneity of Treatment Effects for Patient Subpopulations: Challenges and Opportunities. The goal of this session was to provide a brief overview of FDA-regulated therapeutics, including drugs, biologics and medical devices, and some of the major sources of heterogeneity of treatment effects (HTE) related to patient demographics, such as age, sex and race. The panel discussed the US Food and Drug Administration's role in reviewing and regulating drugs, devices, and biologic products and the challenges associated with ensuring that diverse patient populations benefit from these therapeutics. Ultimately, ensuring diverse demographic inclusion in clinical trials, and designing basic and clinical research studies to account for the intended patient population's age, sex, race, and genetic factors among other characteristics, will lead to better, safer therapies for diverse patient populations.     

Racial witnessing and the formation of los conscientes – race critical preservice teachers

This article introduces the concept of racial witnessing – i.e. defining moments where an individual experiences a strong event in which they (or someone they care deeply about) were racialized, Othered, and/or treated differently (usually negatively) because of their racial group, racial affiliation, etc. It is these moments of racial witnessing that are pivotal in the development of los conscientes. These were the more critical-minded preservice teachers who demonstrated a greater understanding regarding race and racism and the impacts it has on the educational system and human lives. This article argues that it is not a specific variable and/or experience (such as those gained in field experiences) that creates race consciousness among preservice teachers. It is the accumulation of racial witnessing events that allow for a deeper understanding of how race dictates lives.     

Justice Sensitivity in Childhood and Adolescence

Individuals differ in their sensitivity toward injustice. Justice‐sensitive persons perceive injustice more frequently and show stronger responses to it. Justice sensitivity has been studied predominantly in adults; little is known about its development in childhood and adolescence and its connection to prosocial behavior and emotional and behavioral problems. This study evaluates a version of the justice sensitivity inventory for children and adolescents (JSI‐CA5) in 1472 9‐ to 17‐year olds. Items and scales showed good psychometric properties and correlations with prosocial behavior and conduct problems similar to findings in adults, supporting the reliability and validity of the scale. We found individual differences in justice sensitivity as a function of age and gender. Furthermore, justice sensitivity predicted emotional and behavioral problems in children and adolescents over a 1‐ to 2‐year period. Justice sensitivity perspectives can therefore be considered as risk and/or protective factors for mental health in childhood and adolescence.     

Work Trajectories of Female and Male Immigrants in Spain

This article aims to examine in depth the work trajectories of individuals over time, in order to provide a wider perspective of the employment history of immigrants compared to native people, by gender and for more than one decade (2005–2017) in Spain. We use microdata (cohort and multivariate analysis) from the Labour Force Survey and carry out a comparison for three groups: the Spanish born in Spain, the Spanish born abroad, and the non-Spanish born abroad. The results confirm that the non-Spanish born-abroad group is characterized by the existence of segmented assimilation. All foreigners suffered a loss in their work trajectories, since their employment rate in 2017 has as yet neither reached the level of the last years of the previous economic expansion nor the level of the previous cohorts at the same age.     

Social network effects on academic achievement

How peer groups contribute to educational outcomes has long interested researchers. However, the possibility that peer groups dominated by either low- or high-achieving youth can have substantively different effects on achievement has been largely ignored. In this paper, we show that while being embedded in a high-achieving network of friends is not associated with increased own achievement, being embedded in a low-achieving network is associated with decreased own achievement. In additional analyses, we present evidence that these associations are at least in part due to influence, as opposed to only selection effects or shared environment. We also examine whether the structure of the network in which a student is embedded might affect their educational achievement. We show that achieving at higher levels positively predicts how centrally located a student is in their network, but being more centrally located does not predict concurrent achievement. This finding suggests that the behavior of individuals is affecting the formation of network structure and not the reverse.     

Stressful Life Events and Physical and Psychological Health: Mediating Effects of Differentiation of Self in a Spanish Sample

The pathways between differentiation of self and health remain only partly elucidated. This cross‐cultural study sought to test Bowen's hypothesis about the associations between differentiation, stressful life events, and physical and psychological health, in a sample of 466 Spanish adults. Results show that people with higher levels of differentiation were less prone to physical ailments (e.g., heart disease, cancer, or blood disorders) and psychological symptoms (e.g., depression or anxiety). Further, differentiation mediated the association between stress (i.e., perceived negativity of stress in the past year and number of stressful events across the lifetime) and physical and psychological health. The current research provides cross‐cultural empirical evidence for the links between differentiation and mind and body health in a Mediterranean culture.     

From Tupperware to Scentsy: The gendered culture of women and direct sales

Consumer culture has transformed the lives of working women and family life for well over a century. Perhaps one of the most gender distinct forms of consumer culture introduced in the 20th century was the direct sales industry. The business model of direct sales depends on women's social circles as a means to market products directly to consumers, antithetical to retail spaces of malls and shopping outlets. In this literature review, I explore how women construct meaning behind products in this sales culture, while examining the emotional investment that women make as direct sales consultants and the personal outcomes of this investment. To begin, I include a brief history of the direct sales industry with a focus on three pioneering companies: Avon, Tupperware, and Mary Kay as foundational to women's contributions and involvement in the industry today. Next, I explore the pathways that motivate women's draw to direct selling as a form of emotional labor that allows them to balance professional work and family life while yielding minimal financial gain. I analyze the messaging of direct sales companies that cleverly speak directly to women's needs for recognition and assist in constructing personal identity and self‐worth. Finally, I examine trends for the future of direct sales companies as they look to maintain relevance through global markets and brand recognition that will expand beyond women's social circles and parties.