独生子女大学生运动项目特点研究

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Type I error rates from likelihood‐based repeated measures analyses of incomplete longitudinal data

The last observation carried forward (LOCF) approach is commonly utilized to handle missing values in the primary analysis of clinical trials. However, recent evidence suggests that likelihood‐based analyses developed under the missing at random (MAR) framework are sensible alternatives. The objective of this study was to assess the Type I error rates from a likelihood‐based MAR approach – mixed‐model repeated measures (MMRM) – compared with LOCF when estimating treatment contrasts for mean change from baseline to endpoint (Δ). Data emulating neuropsychiatric clinical trials were simulated in a 4 × 4 factorial arrangement of scenarios, using four patterns of mean changes over time and four strategies for deleting data to generate subject dropout via an MAR mechanism. In data with no dropout, estimates of Δ and SE_Δ from MMRM and LOCF were identical. In data with dropout, the Type I error rates (averaged across all scenarios) for MMRM and LOCF were 5.49% and 16.76%, respectively. In 11 of the 16 scenarios, the Type I error rate from MMRM was at least 1.00% closer to the expected rate of 5.00% than the corresponding rate from LOCF. In no scenario did LOCF yield a Type I error rate that was at least 1.00% closer to the expected rate than the corresponding rate from MMRM. The average estimate of SE_Δ from MMRM was greater in data with dropout than in complete data, whereas the average estimate of SE_Δ from LOCF was smaller in data with dropout than in complete data, suggesting that standard errors from MMRM better reflected the uncertainty in the data. The results from this investigation support those from previous studies, which found that MMRM provided reasonable control of Type I error even in the presence of MNAR missingness. No universally best approach to analysis of longitudinal data exists. However, likelihood‐based MAR approaches have been shown to perform well in a variety of situations and are a sensible alternative to the LOCF approach. MNAR methods can be used within a sensitivity analysis framework to test the potential presence and impact of MNAR data, thereby assessing robustness of results from an MAR method. Copyright © 2004 John Wiley & Sons, Ltd.     

毛泽东"一条线"外交战略的得失及其启示

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论居民住房买卖所有权的取得

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从对抗、依赖到利用的性别修辞——由女性小说的解读透视女性生存

女性文学在当代中国的发展历程由80年代的强调女性自立、男女平等等造成了新的性别困惑和压迫，到90年代的张扬性别意识、身体写作导致女性的物化，再到90年代末盛行的“小女人散文”的巧用自身优势去赢得社会认同。拟从这些具有典型意义的文本中透视女性的生存，从而给现实生活中的女性一些启示——积极利用自身优势去获得发展的机会。     

近百年来中国对文物建筑与历史地段的保护

论文以1949年为界,分两大部分叙述了迄今为止大约100年来中国对文物建筑与历史地段的保护。总结出1949年后中国近代文物建筑保护思想观念的演变特征,即前期以具有社会主义特色的保护观念为主,80年代以来发展为逐渐与国际接轨。     

学术期刊的一稿多投现象研究述评

对1994年以来有关学术期刊一稿多投现象的研究成果进行了综述.从一稿多投的定义、表现形式、形成原因、防范措施以及处罚措施等方面进行了总结和分析.     

论20世纪50年代中美在台湾问题上的较量

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论王韬的"天下一道"观

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论经济及企业活动中的单向因果循环

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