| 速肿消注射液毒性研究 |
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| 引用本文： | 罗永煌,李竞,罗跃美.速肿消注射液毒性研究[J].西南农业大学学报(社会科学版),2000(2). |
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| 作者姓名： | 罗永煌 李竞 罗跃美 |
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| 作者单位： | 四川畜牧兽医学院动物药物研究所，四川畜牧兽医学院动物药物研究所，四川畜牧兽医学院动物药物研究所 重庆荣昌 402460，重庆荣昌 402460，重庆荣昌 402460 |
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| 摘 要： | 为提供速肿消注射液的安全性毒理学评价资料，本试验采用改良Ｋａｒｂｅｒ法测定小鼠ＬＤ５０；以剂量递增法测定小鼠蓄积性和耐受性；分别以剂量 ５００、２００、１００ｍｇ／ｋｇ为３个试验组，设阴性和阳性对照组进行小鼠骨髓微核试验；分别以剂量 ７５０、３７５、１８８ ｍｇ／ｋｇ为３个剂量组，设阴性和阳性对照组进行小鼠精子畸形试验。结果表明：其ＬＤ５０为９９４．７２ ｍｇ／ｋｇ，蓄积系数大于５．３，无显著积毒性和耐受性（Ｐ＞０．０５），小鼠骨髓微核试验和精子畸形试验结果均为阴性。
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| 关 键 词： | 速肿消 LD50 蓄积毒性 耐受性 骨髓微核 精子畸形 |
STUDY ON THE TOXICITY OF SU ZHONGXIAO INJECTION |
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| Luo Yonghuang,Li Jing,LuoYuemei.STUDY ON THE TOXICITY OF SU ZHONGXIAO INJECTION[J].Journal of Southwest Agricultural University:Social Science Edition,2000(2). |
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| Authors: | Luo Yonghuang Li Jing LuoYuemei |
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| Institution: | Luo Yonghuang;Li Jing;LuoYuemei |
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| Abstract: | In order to provide some scientific data for safety evaluation of WU ZHONG XIAO injection this paper detemines LD50;by improved karber method,accumulative toxicity by progressive dose increase method,bone marrow micronucleus test with3 experimental groups at dosage of 500,200 and 100mg/kg respectively and positive and negative control groups, spermatogenic malformative test with 3 experimental groups at dosage of 750,375 and 188 mg/kg respectively and positive and negative control groups. It also determines the tolerance. Experimental animals used in these 5 tests are mice. The data are 994 .72 mg/kg and over 5. 3(accumulative coefficient). The other 3 results are all negative. |
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| Keywords: | SU ZHON XIAO ID50 Accumulative toxicity Tolerance Bone marrow micronucleus Spermatogenic malformation |
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