Randomized p-values for multiple testing of composite null hypotheses |
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Authors: | Thorsten Dickhaus |
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Affiliation: | Department of Mathematics, Humboldt-University Berlin, Unter den Linden 6, 10099 Berlin, Germany |
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Abstract: | We are considered with the problem of m simultaneous statistical test problems with composite null hypotheses. Usually, marginal p-values are computed under least favorable parameter configurations (LFCs), thus being over-conservative under non-LFCs. Our proposed randomized p-value leads to a tighter exhaustion of the marginal (local) significance level. In turn, it is stochastically larger than the LFC-based p-value under alternatives. While these distributional properties are typically nonsensical for m =1, the exhaustion of the local significance level is extremely helpful for cases with m>1 in connection with data-adaptive multiple tests as we will demonstrate by considering multiple one-sided tests for Gaussian means. |
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Keywords: | Data-adaptive multiple test False discovery rate Family wise error rate Quantile transformation Schweder&ndash Spjø tvoll estimator Simultaneous statistical inference |
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