|
|||||
|
|
Impact of metabolic status on the association of serum vitamin D with hypogonadism and lower urinary tract symptoms/benign prostatic hyperplasia |
|
| Authors: | Sun Gu Park Jeong Kyun Yeo Dae Yeon Cho |
| Affiliation: | 1. Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Korea;2. Department of Urology, Inje University Seoul Paik Hospital, Seoul, Korea;3. Department of Urology, Inje University, Sanggye Paik Hospital, Seoul, Korea |
| Abstract: | Objective: The objective of this study is to investigate the impact of metabolic status on associations of serum vitamin D with hypogonadism and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH). Patients and methods: A total of 612 men underwent physical examination, biochemical/hormonal blood testing, and transrectal prostate ultrasound. Moreover, the subjects filled out standard questionnaires for identification and grading of LUTS and hypogonadism symptoms. Parameters were statistically compared with independent t-tests and correlation analyses. Results: Vitamin D levels positively correlated with total testosterone (TT) but not with prostate volume or International Prostate Symptom Score (IPSS). Patients with metabolic syndrome had significantly lower vitamin D levels, which were not correlated with TT, prostate volume, or IPSS. However, vitamin D was positively correlated with TT, and negatively correlated with prostate volume and quality-of-life IPSS in subjects without metabolic syndrome. Conclusion: The clinical usefulness of vitamin D for treatment of hypogonadism or LUTS/BPH varies according to metabolic status. |
| Keywords: | Serum vitamin D testosterone hypogonadism lower urinary tract symptoms benign prostate hyperplasia metabolic syndrome |