The impact of testosterone replacement therapy on glycemic control,vascular function,and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes |
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| Authors: | Kristina Groti Ivan Žuran Blaž Antonič Lidija Foršnarič Marija Pfeifer |
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| Affiliation: | 1. Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center, Ljubljana, Slovenia;2. kristina.groti@icloud.com;4. Department of Angiology, Endocrinology and Rheumatology, General Hospital Celje, Celje, Slovenia;5. Bla? Antoni? s.p., IT Equipment Development, Ljubljana, Slovenia;6. Medical Faculty, University of Ljubljana, Ljubljana, Slovenia |
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| Abstract: | Objective: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2).Study design: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n?=?28) was treated with testosterone undecanoate (1000?mg i.m. every 10?weeks) while group P (n?=?27) received placebo.Methods: Anthropometrical and vascular measurements – flow-mediated dilatation (FMD) and intima media thickness (IMT) – biochemical and hormonal blood sample analyses were performed at the start of the study and after one year. Derived parameters (BMI, HOMA-IR, calculated free testosterone (cFT) and bioavailable testosterone (BT)) were calculated.Results: TRT resulted in reduction of HOMA-IR by 4.64?±?4.25 (p?p?p?=?.005).Conclusion: TRT normalized serum testosterone levels, improved glycemic control and endothelial function while exerting no ill effects on the study population. |
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| Keywords: | Diabetes testosterone replacement therapy hypogonadism metabolic syndrome insulin resistance endothelial function intima media thickness |
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