Abstract: | This study examined the mediating processes linking assertiveness and decision making to early adolescent substance initiation, along with the moderating effect of gender on those processes. Models specifying negative expectancies and refusal intentions as mediators of individual rights assertiveness and decision‐making effects on substance initiation were evaluated across 18 months on a nontreatment cohort of young adolescents participating in a prevention trial (average age 12.3 years at baseline; N=357). Results indicated that individual rights assertiveness and decision making had indirect effects on substance initiation through effects on negative outcome expectancies and refusal intentions. Gender differences were found in both the average level and the pattern of relationships among the variables. For girls, refusal intentions were negatively associated with later substance initiation. For boys, early levels of substance initiation were negatively associated with later levels of negative expectancies and refusal intentions. Implications for prevention programming are discussed. |