老年冠心病患者口腔牙周现况及外周血、龈沟液炎性标识指标对照分析

目的对照分析老年冠心病（CHD）患者口腔牙周现况及外周血、龈沟液（GCF）炎性标识指标水平。方法连续选择2013年1月到2013年4月在解放军沈阳军区总医院心内科住院治疗的老年CHD患者47例，对照组入选同时间参加我院体检结论健康老年人42倒。两组对象均接受了口腔牙周检查及外周血、GCF处炎性标识指标（IL-1β、IL-6、TNF-α和hs—CRP）检测。结果老年CHD组的牙周炎及牙周病患病率分别为53．19％（25例）和72．34％（34例），均明显高于对照组（13例，27．65％，χ^2=6．59和10例，23．81％，χ^2=9．15；均P〈0．01）。老年CHD组的临床附着丧失、牙周探诊深度、龈沟出血指数、牙齿松动度、牙齿填充指数及简化口腔卫生指数均明显差于对照组（P〈0．05，P〈0．01）；老年CHD组的外周血IL-1β、IL-6、TNF-α和hs-CRP水平均显著高于对照组，老年CHD组的GCF处IL-1β、IL-6、TNF-α均显著高于对照组（P〈0．05P〈0．01）。结论老年CHD患者口腔牙周卫生状况差，牙周疾病患病率增加，外周血及GCF处炎性标识指标水平明显升高。

Oral hygiene status and expression of inflammatory factors in peripheral blood and gingival crevicular fluid of elderly patients with coronary artery disease

Objective To investigate the oral hygiene status and to analyze the expression of inflammatory factors in the peripheral blood and gingival crevicular fluid （GCF） of elderly patients with coronary artery disease （CHD）. Methods A total of 47 CHD elderly patients and 42 healthy controls were selected from Department of Cardiology, General Hospital of Shenyang Military Area Command of Chinese PLA from January to Apirl,2013. All the cases were treated by periodontal examination and flammatory factors,including IL-1β、IL-6、TNF-α and hs-CRP, in the peripheral blood and GCF. Results The periodontitis prevalence was 53.19% （n = 25）, and the prevalence of periodontal disease was 72. 34% （n = 34） in the CHD group,which were signifi- cantly higher than 27. 65% （n = 13 ,x =6. 59） and 23.81% （n = 10,x =9. 15） in the control group（P 〈0. 01 ）. The clinical attachment loss, periodontal probing depth, sulcular bleeding index,tooth mobility, decayed missing filled tooth and simplified oral hygiene index in the CHD group were significantly lower than those in the control group （ P 〈 0. 05, P 〈 0. 01 ）. In the peripheral blood, the expression levels of IL-1β、IL-6、TNF-α and hs-CRP in the CHD group were significantly higher than those in the control group;additionally,in the GCF,the expression levels of IL-1β、IL-6、TNF-α in the CHD group were significantly higher than those in the control group （ P 〈 0.05,P 〈 0.01 ）. Conclusion The oral hygiene status is poor, the prevalence of periodontal disease is increased, and the expression of inflammatory factors in the peripheral blood and GCF is increased in the CHD elderly patients.