| DNA甲基化检测方法的研究进展 |
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| 引用本文： | 孙贝娜.DNA甲基化检测方法的研究进展[J].福建农林大学学报(哲学社会科学版),2009(4). |
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| 作者姓名： | 孙贝娜 |
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| 作者单位： | 生物芯片上海国家工程研究中心; |
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| 摘 要： | DNA甲基化是一种重要的遗传外修饰,是表观遗传学(epigenetics)的重要组成部分l]。它参与了动物胚胎发育、基因印迹和X染色体失活等过程,在基因表达的调控中具有重要作用,异常甲基化可以导致肿瘤的形成。近20年来,DNA甲基化的研究逐渐成为新的研究热点。随着对甲基化研究的不断深人,各种各样甲基化检测方法被开发出来以满足不同类型研究的要求。本文对目前现有常用的CpG岛甲基化检测方法作一综述,并着重介绍几项以芯片技术为基础的高通量研究DNA甲基化的方法。
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| 关 键 词： | DNA甲基化 甲基化检测方法 芯片 |
Advance In The Profile of DNA Methylation Technology |
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| Bei-Na Sun.Advance In The Profile of DNA Methylation Technology[J].Journal of Fujian Agriculture and Forestry University,2009(4). |
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| Authors: | Bei-Na Sun |
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| Institution: | National Engineering Center for Biochip at Shanghai;Shanghai 201203 |
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| Abstract: | DNA methylation is a kind of important epigenetic modification, which is an important component for epigenetics.DNA methylation participates in the process of animal embryo development, genomic imprinting and X chromosome inactivation, which plays an important role in regulation of gene expression.Abnormal DNA methylation can lead tumor formation.In recenet 20 years, study on DNA methylation has become new hotspot.With the deeper of DNA methylation study, many kinds of methods of DNA methylation detection h... |
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| Keywords: | DNA methylation methylation detection technology microarray |
| 本文献已被 CNKI 等数据库收录！ |
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