Two-Level Designs in Blocks of Size Two in Which All Main Effects and Two-Factor Interactions Are Estimable

There are many problems in the real world for which it is necessary to perform two points in one block. In this situation, information about certain treatments may be indistinguishable from, or confounded with, blocks. If the experimenter wants to estimate all main effects and two-factor interactions in which two points are in one block, then how to perform the blocking schemes is an important topic to study. In this article, we combine several 2 ^k?p fractions from same or different family to obtain better combined designs requiring fewer runs than those appearing in the literature.