首页 | 本学科首页   官方微博 | 高级检索  
     


Collective versus Individual Effects in Survival Analysis of Multiple Failures
Authors:Jialiang Li  Zhipeng Huang  Shuangge Ma  Mei‐Ling Ting Lee
Affiliation:1. Department of Statistics and Applied ProbabilityNational University of Singapore;2. Duke‐NUS Graduate Medical School;3. Singapore Eye Research Institute;4. Yale University;5. VA Cooperative Studies Program Coordinating Center;6. University of Maryland
Abstract:In survival analysis, we sometimes encounter data with multiple censored outcomes. Under certain scenarios, partial or even all covariates have ‘similar’ relative risks on the multiple outcomes in the Cox regression analysis. The similarity in covariate effects can be quantified using the proportionality of regression coefficients. Identifying the proportionality structure, or equivalently whether covariates have individual or collective effects, may have important scientific implications. In addition, it can lead to a smaller set of unknown parameters, which in turn results in more accurate estimation. In this article, we develop a novel approach for identifying the proportionality structure. Simulation shows the satisfactory performance of the proposed approach and its advantage over estimation under no assumed structure. We analyse three datasets to demonstrate the practical application of the proposed approach.
Keywords:collective covariate effects  Cox model  multiple survival times  proportionality
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号