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Biologically Motivated Cancer Risk Models |
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| Authors: | Todd W. Thorslund Charles C. Brown Gail Charnley |
| Affiliation: | ICF-Clement, Associates, 1850 K Street, N.W., Washington, D.C. 20006 (formerly with U.S. Environmental Protection Agency).;National Cancer Institute.;ICF-Clement;Massachusetts Institute of Technology (formerly with National Research Council). |
| Abstract: | A two-stage dose response model is proposed for use in cancer risk assessment. The model assumes that transformation probabilities and cellular dynamics are exposure- and time-dependent. |
| Keywords: | Biologically based low-dose extrapolation cell proliferation |