盐酸多奈哌齐治疗血管性痴呆的临床疗效观察

目的观察盐酸多奈哌齐治疗血管性痴呆的疗效。方法102例血管性痴呆患者随机分为2组，治疗组51例，在常规治疗的基础上给予盐酸多奈哌齐5mg，每日1次；对照组54例，给予常规治疗，两组患者疗程均为12周，观察治疗前后认知功能（MMSE、HDS）及日常生活自理能力（ADL）的改善程度。结果治疗12周时，治疗组MMSE、HDS及ADL评分明显改善，较对照组有显著性差异（P〈0．05），自身对照结果显示，盐酸多奈哌齐治疗12周，治疗后MMSE、HDS及ADL评分较治疗前改善（P〈0．01），在治疗4周时，MMSE、HDS及ADL评分已有提高。结论盐酸多奈哌齐治疗血管性痴呆疗效确切，对患者认知功能及日常生活能力均为改善，无明显副作用，值得临床推广。

The Clinical Observation of Efficiency of Donepezil in Treatment of Vascular Dementia

Objective To evaluate the efficiency of donepezil for vascular dementia(VaD). Methods 105 cases of patients with VaD were randomly divided into 2 groups;the treated group(51 cases) and the control group(54 cases),patients in treated group were given donepezil(5mg,once daily) in the foundation of conventional therapy;and other group was treated by conventional therapy,taking 12 weeks clinical therapy,To observate the degree of improvement for the cognitive function(MMSE,HDS) and the ability of taking care of oneself(ADL). Results After 12 weeks,the marks of MMSE,HDS and ADL of the treatment group were more evidently improved than that of the control group(P<0.05),the study indicated that the marks of MMSE,HDS,ADL compare to the comparison group improved in turn after treatment(P<0.01),after having been treated for 4 weeks,the marks of MMSE,HDS and ADL have been improved(P<0.05). Conclusion Donepezil which can improve the cognitive function and the ability of taking care of oneself,is effective for VaD and no side effect,worthing spreading in clinic.