甘肃省出生缺陷1：2配对病例对照研究

为了解甘肃省出生缺陷死亡率及易患因素,为“甘肃省出生缺陷干预工程”项目的实施提供可干预的核心因素。根据甘肃地理特点及经济状况,按随机分层整群抽样方法,抽取了4个县,共42个乡为调查点。结果显示四县市婴儿总死亡率15.8‰(98例),出生缺陷死亡率7.7‰。甘肃省出生缺陷前五位的致病因素依次为:母亲孕早期接触农药史;母亲孕前一月服药史;母亲孕期接触农药史;母亲孕早期感染史;既往流产史。

A case-control study of birth defects in Gansu

Objective The purposes of the investigation were to determine the prevalence of birth defects and to examine the risk factors that maybe make this population more susceptible to the development of birth defects so and to supply some core risk factors for the intervention project on birth defects in Gansu province, West China. Method Forty-two communities of four counties were randomly selected by stratification cluster sampling for the survey on the states of economic and geographical features in the province. The case-control study was adopt in which a matches including both case of infant of birth defects and control of two normal infants who had same age, sex and inhabitation. Infants born under five years old were investigated. The parents of these infants were contacted and completed by investigators regarding the prenatal and postnatal history of their child.. The disease types of birth defects were classed by the diagnosis standardization of congenital anomalies. Result These mortality rate of infant in four counties in Gansu was 15.8%. The mortality of birth defects attributable to IMBD was 49.0%. The first five risk factors of birth defects were: contact with pesticide in forepart pregnant ; dose history in one mouth before pregnant;contacted with pesticide before pregnant;infected history in forepart pregnant;miscarriage history; Conclusion That women in forepart pregnant and before pregnant avoid to contact with risk factors are where the shoe pinches of intervention birth defects.