Measuring resetting of brain dynamics at epileptic seizures: application of global optimization and spatial synchronization techniques |
| |
Authors: | Shivkumar Sabesan Niranjan Chakravarthy Kostas Tsakalis Panos Pardalos Leon Iasemidis |
| |
Institution: | (1) Department of Electrical Engineering, Arizona State University, Tempe, AZ 85287, USA;(2) The Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287, USA;(3) Department of Industrial and Systems Engineering, University of Florida, Gainsville, FL 32611, USA |
| |
Abstract: | Epileptic seizures are manifestations of intermittent spatiotemporal transitions of the human brain from chaos to order. Measures
of chaos, namely maximum Lyapunov exponents (STL
max
), from dynamical analysis of the electroencephalograms (EEGs) at critical sites of the epileptic brain, progressively converge
(diverge) before (after) epileptic seizures, a phenomenon that has been called dynamical synchronization (desynchronization).
This dynamical synchronization/desynchronization has already constituted the basis for the design and development of systems
for long-term (tens of minutes), on-line, prospective prediction of epileptic seizures. Also, the criterion for the changes
in the time constants of the observed synchronization/desynchronization at seizure points has been used to show resetting
of the epileptic brain in patients with temporal lobe epilepsy (TLE), a phenomenon that implicates a possible homeostatic
role for the seizures themselves to restore normal brain activity. In this paper, we introduce a new criterion to measure
this resetting that utilizes changes in the level of observed synchronization/desynchronization. We compare this criterion’s
sensitivity of resetting with the old one based on the time constants of the observed synchronization/desynchronization. Next,
we test the robustness of the resetting phenomena in terms of the utilized measures of EEG dynamics by a comparative study
involving STL
max
, a measure of phase (φ
max
) and a measure of energy (E) using both criteria (i.e. the level and time constants of the observed synchronization/desynchronization). The measures
are estimated from intracranial electroencephalographic (iEEG) recordings with subdural and depth electrodes from two patients
with focal temporal lobe epilepsy and a total of 43 seizures. Techniques from optimization theory, in particular quadratic
bivalent programming, are applied to optimize the performance of the three measures in detecting preictal entrainment. It
is shown that using either of the two resetting criteria, and for all three dynamical measures, dynamical resetting at seizures
occurs with a significantly higher probability (α=0.05) than resetting at randomly selected non-seizure points in days of EEG recordings per patient. It is also shown that
dynamical resetting at seizures using time constants of STL
max
synchronization/desynchronization occurs with a higher probability than using the other synchronization measures, whereas
dynamical resetting at seizures using the level of synchronization/desynchronization criterion is detected with similar probability
using any of the three measures of synchronization. These findings show the robustness of seizure resetting with respect to
measures of EEG dynamics and criteria of resetting utilized, and the critical role it might play in further elucidation of
ictogenesis, as well as in the development of novel treatments for epilepsy. |
| |
Keywords: | Quadratic binary programming Dynamical Synchronization Spatiotemporal transitions Epileptic seizure dynamics |
本文献已被 PubMed SpringerLink 等数据库收录! |
|