| Abstract: | There are few distribution-free methods for detecting interaction in fixed-dose trials involving quantal response data, despite the fact that such trials are common. We present three new tests to address this issue, including a simple bootstrap procedure. We examine the power of the likelihood ratio test and our new bootstrap test statistic using an innovative linear extrapolation power-estimation technique described in Boos, D. D. and Zhang, J. (2000) in Monte Carlo evaluation of resampling-based hypothesis tests. Journal of the American Statistical Association, 95, 486–492. |
