| Abstract: | Studies on diffusion tensor imaging (DTI) quantify the diffusion of water molecules in a brain voxel using an estimated 3 × 3 symmetric positive definite (p.d.) diffusion tensor matrix. Due to the challenges associated with modelling matrix‐variate responses, the voxel‐level DTI data are usually summarized by univariate quantities, such as fractional anisotropy. This approach leads to evident loss of information. Furthermore, DTI analyses often ignore the spatial association among neighbouring voxels, leading to imprecise estimates. Although the spatial modelling literature is rich, modelling spatially dependent p.d. matrices is challenging. To mitigate these issues, we propose a matrix‐variate Bayesian semiparametric mixture model, where the p.d. matrices are distributed as a mixture of inverse Wishart distributions, with the spatial dependence captured by a Markov model for the mixture component labels. Related Bayesian computing is facilitated by conjugacy results and use of the double Metropolis–Hastings algorithm. Our simulation study shows that the proposed method is more powerful than competing non‐spatial methods. We also apply our method to investigate the effect of cocaine use on brain microstructure. By extending spatial statistics to matrix‐variate data, we contribute to providing a novel and computationally tractable inferential tool for DTI analysis. |
