| 泰乐松注射液的毒理学试验研究 |
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| 引用本文： | 饶勇,廖兰,曾子建,古淑英,李逐波.泰乐松注射液的毒理学试验研究[J].西南农业大学学报(社会科学版),1998(1). |
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| 作者姓名： | 饶勇 廖兰 曾子建 古淑英 李逐波 |
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| 作者单位： | 四川畜牧兽医学院动物医学系!荣昌402460 |
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| 摘 要： | 为提供泰乐松注射液的安全性毒理学评价资料，本试验采用改进Karber法测定小鼠LD_(50)；以剂量递增法测定小鼠蓄积性和耐受性；分别以剂量340、130、30mg／kg为3个试验组．设阴性和阳性对照组进行小鼠骨髓微核试验；分别以剂量500、250、120mg／kg为3个剂量组．设阴性和阳性对照组进行小鼠精于畸形试验。结果表明：其LD_(50)为669．80mg／kg，蓄积系数大于5．3，无明显蓄积毒性和耐受性（P＞0．05），小鼠骨髓微核试验和精子畸形试验结果均为阴性。
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| 关 键 词： | 泰乐松 蓄积毒性 耐受性 骨髓 微核 精子畸形 |
STUDY ON THE TOXICOLOGY TESTS OF TYCLOSONE INJECTION |
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| Rao Yong, Liao Lan, Zheng Zijian et al..STUDY ON THE TOXICOLOGY TESTS OF TYCLOSONE INJECTION[J].Journal of Southwest Agricultural University:Social Science Edition,1998(1). |
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| Authors: | Rao Yong Liao Lan Zheng Zijian |
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| Institution: | Rao Yong; Liao Lan; Zheng Zijian et al. |
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| Abstract: | In order to provide some scientific data for safety evaluation of Tyclosone injection, thispaper determines LD50 by improved karber method, accumulative toxicity by progressive dose in-crease method, bone marrow micronucleus test with 3 experimental groups at dosage of 340, 130and 30 mg/kg respectively and positive and negative control groups, spermatogenic malformativetest with 3 experimental groups at dosage of 500, 250 and 120mg/kg respectively and positive andnegative control groups. It also determines the tolerance. Experimentive animals used in these 5tests are mice. The data are 669. 80mg/kg(LD50) and over 5. 3 (accumulative coefficient). Theother 3 rasults are all negative. |
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| Keywords: | Tyclosone injection LD_(50) Accumulative toxicity test Tolerancd test Bone marrow micronucleus test Spermatogenic malformative test |
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