A Measure of partial association between disease and genotype for the two-parent problem

The two-parent disease-genotype association problem is studied from the point of view of a coefficient of association between the disease phenotype of the child and the disease phenotypes of the parents, in the presence of some genotypic information about the parents. This coefficient of partial association is derived, and certain tests of hypotheses are constructed. The results are shown to be useful in estimation of recurrence risks, and in understanding the nature of the association between child and parental disease phenotypes.