More flexible sequential and non-sequential designs in long-term clinical trial |
| |
| Authors: | K.K. Gordon Lan David L. Detlets Max Halperin |
| |
| Affiliation: | 1. National Heart, Lung, and Blood Institute , NIH Bethesda, MD, 20205;2. University of Wisconsin , Madison, WI, 53706;3. George Washington University , Washington, DC |
| |
| Abstract: | ![]()
In this paper, we describe decision making procedures as they exist in most clinical trials,review some recently suggested approaches to monitoring and clarify how these methods allow greater flexibility in monitoring and explicit specification of data monitoring methods in the protocol. |
| |
| Keywords: | stochastic curtailing data monitoring decision times |
|
|
