Nonparametric estimation of the survival distribution in censored data |
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Authors: | Thomas R. Fleming David P. Harrington |
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Affiliation: | 1. Consultant Department of Medical Statistics and Epidemiology , Mayo Clinic , Rochester, Minnesota, 55905;2. Associate Professor Department of Biostatistics , Harvard University , Boston, 02155, Massachusetts |
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Abstract: | Two nonparametric estimators o f the survival distributionare discussed. The estimators were proposed by Kaplan and Meier (1958) and Breslow (1972) and are applicable when dealing with censored data. It is known that they are asymptotically unbiased and uniformly strongly consistent, and when properly normalized that they converge weakly to the same Gaussian process. In this paper, the properties of the estimators are carefully inspected in small or moderate samples. The Breslow estimator, a shrinkage version of the Kaplan-Meier, nearly always has the smaller mean square error (MSE) whenever the truesurvival probabilityis at least 0.20, but has considerably larger MSE than the Kaplan-Meier estimator when the survivalprobability is near zero. |
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Keywords: | Key Words and Phrases: Kaplan-Meier estimator mean squared error nonparametrio estimation survival distribution censored data |
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