Caloric restriction minimizes aging effects on the femoral medial condyle |
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| Authors: | Renata Gabriel Fontinele Eliane Florencio Gama Renata de Brito Mari Romeu Rodrigues de Souza André Conrado |
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| Affiliation: | 1. Department of Surgery, Faculty of Veterinary Medicine and Zootecny, S?o Paulo University, S?o Paulo, Brazil;2. Department of Physical Education, Laboratory of Morphoquantitative Studies and Immunohistochemistry, S?o Judas Tadeu University, S?o Paulo, Brazil;3. Department of Morphological Sciences, Maringá State University, Maringá, Brazil;4. Department of Anatomy, S?o Judas Tadeu University, S?o Paulo, Brazil |
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| Abstract: | ![]()
This study aimed to analyze the effects of caloric restriction on aged femoral articular cartilage of Wistar rats. Three groups of eight animals each were considered: young (YC) and old (OC) control groups fed with a normal diet and old caloric restriction group (OCR) composed of 18-month-old animals fed with a 31% less caloric diet from 6-months of age. Articular cartilage was studied through morphometry and immunohistochemistry. Body mass was 12% less in the OCR group than in the OC group. The articular cartilage from OC rats show thinner medial condyles, fewer chondrocytes, smaller chondrocytes nuclear volume and, in both condyles, a predominance of collagen type II and less collagen density compared to both YC and OCR groups (p?p?
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| Keywords: | Morphometry hipocaloric nutrition articular cartilage Wistar rats |
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