| CD14基因多态性与强直性脊柱炎的关联性研究 |
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| 引用本文： | 韩文慧,孟娇,王娇男,李睿尧,张吉林,宋玉国.CD14基因多态性与强直性脊柱炎的关联性研究[J].北华大学学报(社会科学版),2016,17(4):477-480. |
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| 作者姓名： | 韩文慧 孟娇 王娇男 李睿尧 张吉林 宋玉国 |
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| 作者单位： | 北华大学医学检验学院,吉林 吉林,132013;北华大学生命科学研究中心,吉林 吉林,132013 |
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| 基金项目： | 吉林省卫生厅科研计划项目(2010z087)，吉林省教育厅科学技术研究项目(2012129) |
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| 摘 要： | 目的：探讨CD14基因rs2569190位点的单核苷酸多态性与强直性脊柱炎易感性的关系.方法采用PCR-RFLP方法对240例AS患者进行CD14基因多态性检测,并与140名健康对照者进行对比.结果 rs2569190位点基因型频率两组间差异具有统计学意义(χ2=6.778,υ=2,P<0.05)；强直性脊柱炎组携带突变体A基因的频率高于对照组,差异具有统计学意义(χ2=3.876,υ=1,P<0.05).结论 CD14基因rs2569190位点单核苷酸多态性与强直性脊柱炎易感性存在关联,携带CD14突变体A基因者患AS风险较大.
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| 关 键 词： | 强直性脊柱炎 单核苷酸多态性(SNP) 白细胞分化抗原14(CD14) |
Study on the Correlation between CD14 Gene Polymorphism and Ankylosing Spondylitis |
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| Han Wenhui,Meng Jiao,Wang Jiaonan,Li Ruiyao,Zhang Jilin,Song Yuguo.Study on the Correlation between CD14 Gene Polymorphism and Ankylosing Spondylitis[J].Journal of Beihua University(Social Sciences),2016,17(4):477-480. |
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| Authors: | Han Wenhui Meng Jiao Wang Jiaonan Li Ruiyao Zhang Jilin Song Yuguo |
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| Abstract: | Objective To study the correlation between single nucleotide polymorphism of rs2569190 on cluster of differentiation CD14 gene and the susceptibility of ankylosing spondylitis ( AS). Method PCR-RFLP was performed to determine CD14 gene polymorphism of 240 AS patients. Statistical analysis was performed between the patients and 140 healthy controls. Results The frequency difference in genetype of rs2569190 was statistically significant (χ2 =6 . 778 ,υ=2 , P<0 . 05 ) . The frequency of mutant A gene in the patients with ankylosing spondylitis was obviously higher than those in the control group (χ2 =3 . 876 ,υ=1 , P<0 . 05 ) . Conclusion There is significant correlation between the single nucleotide polymorphism of rs2569190 on CD14 gene and the susceptibility of ankylosing spondylitis. The patients carrying CD14 mutant A gene suffer higher risk of AS. |
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| Keywords: | ankylosing spondylitis single nucleotide polymorphism (SNP) cluster of differentiation 14 (CD14) |
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