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Simple heterogeneity variance estimation for meta-analysis
Authors:Kurex Sidik   Jeffrey N. Jonkman
Affiliation:Wyeth Research, Princeton, USA; Mississippi State University, Mississippi State, USA
Abstract:Summary.  A simple method of estimating the heterogeneity variance in a random-effects model for meta-analysis is proposed. The estimator that is presented is simple and easy to calculate and has improved bias compared with the most common estimator used in random-effects meta-analysis, particularly when the heterogeneity variance is moderate to large. In addition, it always yields a non-negative estimate of the heterogeneity variance, unlike some existing estimators. We find that random-effects inference about the overall effect based on this heterogeneity variance estimator is more reliable than inference using the common estimator, in terms of coverage probability for an interval estimate.
Keywords:Across-study variance    Confidence intervals    Variance estimation    Weighted residual sum of squares
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