| 绿茶儿茶酚对活性氧和血管细胞增殖的影响研究 |
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| 引用本文： | 杨红,刘贻尧.绿茶儿茶酚对活性氧和血管细胞增殖的影响研究[J].电子科技大学学报(社会科学版),2011(1). |
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| 作者姓名： | 杨红 刘贻尧 |
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| 作者单位： | 电子科技大学生命科学与技术学院; |
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| 基金项目： | 国家自然科学基金(30700151) |
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| 摘 要： | 以内皮细胞、中膜平滑肌细胞和HL-60细胞(异常细胞模型),研究了绿茶儿茶酚对3种细胞增殖的影响。用次黄嘌呤-黄嘌呤氧化酶化学发光法研究了绿茶儿茶酚清除活性氧的效果。研究结果表明,1μg/mL的绿茶儿茶酚略可促进内皮细胞增殖;1、3μg/mL的绿茶儿茶酚对中膜平滑肌细胞增殖没有抑制作用;10μg/mL的绿茶儿茶酚减少中膜平滑肌细胞数量。HL-60细胞数量的减少与绿茶儿茶酚浓度呈剂量效应关系。并发现绿茶儿茶酚对细胞活性氧的清除与剂量有关。
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| 关 键 词： | 动脉粥样硬化 细胞增殖 绿茶儿茶酚 活性氧 |
Effect of Green Tea Catechins on Vascular Cell Proliferation and Reactive Oxygen Species |
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| YANG Hong , LIU Yi-yao.Effect of Green Tea Catechins on Vascular Cell Proliferation and Reactive Oxygen Species[J].Journal of University of Electronic Science and Technology of China(Social Sciences Edition),2011(1). |
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| Authors: | YANG Hong LIU Yi-yao |
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| Institution: | YANG Hong and LIU Yi-yao(School of Life Science and Technology,University of Electronic Science and Technology of China Chengdu 610054) |
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| Abstract: | One of the most important causes of the atherosclerosis is reactive oxygen species(ROS) to induce lipide overoxidation,which leads to endothelial cells dysfunction and vascular smooth muscle cells(VSMCs) abnormal proliferation.Recent investigations demonstrated that polyphenon has prevention effect in the treatment of atherosclerosis or other vascular diseases.In this paper,endothelial cells(ECs),VSMCs and HL-60 cell(as the abnormal cell model) were used to investigate the effects of green tea catechins on ... |
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| Keywords: | atherosclerosis cell proliferation green tea catechins reactive oxygen species |
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