| 通心络对颈动脉粥样硬化临床干预的对照研究 |
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| 引用本文： | 吴娟,付朝晖.通心络对颈动脉粥样硬化临床干预的对照研究[J].决策与信息,2008(9). |
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| 作者姓名： | 吴娟 付朝晖 |
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| 作者单位： | 重庆市第三人民医院老年科 |
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| 摘 要： | 目的探讨通心络是否对颈动脉粥样硬化的发展有抑制作用。方法60例诊断"脑供血不足"的门诊病人,经Hpsonos5500型超声仪,证实颈动脉内膜有硬化改变或硬化斑块,随机进入通心络治疗或对照组。治疗组投给通心络胶囊4粒,3/d,对照组投给阿司匹林75mg/d、舒降之20mg/d,均连服180天。试验前后测定血清氧化低密度脂蛋白(OX-LDL)、单核细胞趋化因子(MCP-1)水平的变化,彩超检查颈动脉粥样硬化情况,观察内-中膜厚度(IMT)、内皮表面情况及硬化斑的变化。结果1.服药半年后两组血浆OX-LDL及MCP-1含量均显著下降(P<0.001)2.两组用药前血浆OX-LDL及MCP-1水平相当,无显著性差异(P>0.05)。治疗180天后,两组水平均明显下降,但对照组下降程度较试验组更明显,组间差异具有显著性(P<0.001)3.彩超示对照组血管IMT有所增加,试验组IMT有轻微增加,但无显著性差异(P>0.05)。结论两组干预对颈动脉粥样硬化的发展均有一定影响,其作用程度相近。病人对通心络胶囊的耐受良好,有高度依从性。
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| 关 键 词： | 颈动脉粥样硬化 IMT OX-LDL MCP-1 |
A CLINICAL-CONTRAL INTERVENTION STUDY ON THE PATIENTS WITH CAROTID ATHEROSCLEROSIS |
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| Wu Juan Fu Zhaohui.A CLINICAL-CONTRAL INTERVENTION STUDY ON THE PATIENTS WITH CAROTID ATHEROSCLEROSIS[J].Decision and Information,2008(9). |
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| Authors: | Wu Juan Fu Zhaohui |
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| Institution: | Wu Juan Fu Zhaohui Department of Gerontology The Third People’s Hospitalof Chongqing; Chongqing 400014; China; |
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| Abstract: | Objective: To investigate the intervention effect on the patients with carotid atherosclerosis . Methods: 60 patients with carotid atherosclerosis complicated by cerebral blood supply unsatisfaction , 30 of whom,as the test group, were treated with Tongxinluo (dose:4# tid ) and the rest, as the control group, were given Simvastatin (dose: 20mg qd ) and aspirin (dose:75mg qd ) for treatment 6 months. Before and after the treatment , determine the IMT of carotid artery, measure OX-LDL and MCP-1 in serum .Comp... |
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| Keywords: | Carotid atherosclerosis Intima-media thickness（IMT） Oxidized low density lipoprotein（OX-LDL） Monocyte chemoattractant protein-1（MCP-1） |
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