| DMAP催化合成白藜芦醇烟酸酯 |
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| 引用本文： | 刘耀武,金传山.DMAP催化合成白藜芦醇烟酸酯[J].宿州学院学报,2010,25(2):39-41. |
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| 作者姓名： | 刘耀武 金传山 |
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| 作者单位： | 安徽中医学院药学院,安徽省现代中药重点实验室,安徽,合肥,230032 |
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| 摘 要： | 目的：以烟酸、白藜芦醇为原料，采用DMAP催化合成方法制备白藜芦醇烟酸酯，期望寻找优化的白藜芦醇烟酸酯合成路线。方法：以烟酸、白藜芦醇为起始原料，经酰氯化、DMAP催化成酯等反应，得到目标化舍物。结论：通过本实验工艺路线合成白藜芦醇烟酸酯，产率90．3％，成酯反应时问比传统方法缩短一半。产物经过1R、1H—NMR等进行了表征。
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| 关 键 词： | 白藜芦醇 白藜芦醇烟酸酯 DMAP催化 |
Synthesis of Resveratrol nicotinate with DMAP as Catalyst |
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| LIU Yao-wu,JIN Chuanshan.Synthesis of Resveratrol nicotinate with DMAP as Catalyst[J].Journal of Shuzhou College,2010,25(2):39-41. |
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| Authors: | LIU Yao-wu JIN Chuanshan |
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| Institution: | LIU Yao-wu,JIN Chuanshan(Anhui Key Laboratory of Modernized Chinese Material,Anhui university of traditional chinese medicine,Hefei Anhui,230038,China) |
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| Abstract: | Obejective:In order to get more active compounds,Resveratrol nicotinate was synthesized by using chemical method with DMAP as Catalyst. Method:The synthesis started with Resveratrol,Nicotinic acid as materials,and after acylation and esterification,then the target compounds were gained.Conclusion:Resveratrol nicotinate is producedd in this experiment,the yield is 90.3%,the reaction time is 1.5~2 h;The product is initially tested by IR,1H-NMR. |
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| Keywords: | resveratrol resveratrol nicotinate synthesis with DMAP as catalyst |
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