| Abstract: | Since its introduction in the mid 1970's, the EM algorithm has found a widespread popularity for solving the likelihood equations. Several investigators have used the algorithm in a variety of problems with incomplete information to obtain maximum likelihood estimates in numerous applications. The algorithm, however, becomes inappropriate when the underlying equations are subject to some constraints. Although an extension has been proposed to derive solutions when the parameters are subject to a set of linear constraints, the evaluation of likelihood equations from incomplete data when the equations are subject to a nonlinear constraint is still an open problem. Here, we consider a mixture model, a classical example of incomplete data, and discuss the problem of maximum likelihood estimation of the model parameters when the parameters have to satisfy a nonlinear constraint. An extension of the EM algorithm based on the celebrated Lagrange multiplier will be proposed to solve the equations. An application of the methodology in animal bioassay experiments for risk assessment of toxic substances will be described and data from a toxicological experiment will be used to illustrate the results. |
