Engineering major has a very large proportion in science and engineering college. Engineering subjects play a great role during the strategy of innovation driven development, because they link to the industrial development closely and provide personnel and technological support for it. The position of applied talent in science and engineering colleges is more strict with talents' practical and innovational abilities, however, the existing personnel training mode is difficult to meet the demand. The problem to be solved is how to cultivate the innovative entrepreneurial talents and enable them to fit the economic and social development. Based on the analysis of the connotation of innovative entrepreneurship education, this paper discusses the necessity of creative talents training and builds innovative entrepreneurial talent training pattern in science and engineering colleges. Four safeguard measures are put forward to provide a reference of carrying out innovation and entrepreneurship education in science and engineering colleges, which are the teaching staff, management system, organization and budget.