| 抗结肠炎药美沙拉嗪的合成改进研究 |
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| 引用本文： | 孟江平,郑霞. 抗结肠炎药美沙拉嗪的合成改进研究[J]. 重庆文理学院学报, 2013, 32(5): 73-75 |
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| 作者姓名： | 孟江平 郑霞 |
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| 作者单位： | 重庆文理学院材料与化工学院,重庆永川,402160 |
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| 基金项目： | 重庆市自然科学基金资助项目，重庆文理学院重点项目，重庆文理学院学生科研项目 |
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| 摘 要： | 以水杨酸为原料,采用浓硝酸/冰醋酸作为硝化剂,合成5-硝基水杨酸；再用铁粉还原制得抗结肠炎药美沙拉嗪.合成路线简便,操作简单,设备腐蚀较小,反应条件温和,收率较高,适合工业化生产.
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| 关 键 词： | 抗结肠炎 水杨酸 5-硝基水杨酸 美沙拉嗪 |
Improvement on the synthesis of anti-colitis drug Mesalazine |
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| MENG Jiangping and ZHENG Xia. Improvement on the synthesis of anti-colitis drug Mesalazine[J]. Journal of Chongqing University of Arts and Sciences, 2013, 32(5): 73-75 |
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| Authors: | MENG Jiangping and ZHENG Xia |
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| Affiliation: | School of Materials and Chemical Engineering, Chongqing University of Arts and Sciences, Yongchuan Chongqing 402160, China;School of Materials and Chemical Engineering, Chongqing University of Arts and Sciences, Yongchuan Chongqing 402160, China |
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| Abstract: | 5-nitrosalicylic acid was synthesized using salicylic acid as raw material and nitric acid / glacial acetic acid as nitrating agent. Then, the Mesalazine was prepared by reduction. The method is characterized with simple route, easy operation, less corrosion, moderate reaction condition and high yield. It is suitable for industrial production. |
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| Keywords: | anti-colitis salicylic acid 5-nitrosalicylic acid Mesalazine |
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