Increasing the Power of the Test Through Pre-Test – A Robust Method

Robust test procedures are developed for testing the intercept of a simple regression model when the slope is (i) completely unspecified, (ii) specified to a fixed value, or (iii) suspected to be a fixed value. Defining (i) unrestricted (UT), (ii) restricted (RT), and (iii) pre-test test (PTT) functions for the intercept parameter under the three choices of the slope, tests are formulated using the M-estimation methodology. The asymptotic distributions of the test statistics and their asymptotic power functions are derived. The analytical and graphical comparisons of the tests reveal that the PTT achieves a reasonable dominance over the other tests.     

Testing equality of two intercepts for the parallel regression model with non sample prior information

This paper proposes tests for equality of intercepts of two simple regression models when non sample prior information is available on the equality of two slopes. For three different scenarios on the values of the slope, namely (i) unknown (unspecified), (ii) known (specified), and (iii) suspected, we derive the unrestricted test (UT), restricted test (RT), and pre-test test (PTT) for testing the equality of intercepts. The test statistics, their sampling distributions, and power functions of the tests are obtained. Comparison of power function and size of the tests reveals that the PTT has a reasonable dominance over the UT and RT.     

Estimation of the intercept parameter for linear regression model with uncertain non-sample prior information

This paper considers alternative estimators of the intercept parameter of the linear regression model with normal error when uncertain non-sample prior information about the value of the slope parameter is available. The maximum likelihood, restricted, preliminary test and shrinkage estimators are considered. Based on their quadratic biases and mean square errors the relative performances of the estimators are investigated. Both analytical and graphical comparisons are explored. None of the estimators is found to be uniformly dominating the others. However, if the non-sample prior information regarding the value of the slope is not too far from its true value, the shrinkage estimator of the intercept parameter dominates the rest of the estimators.     

Shrinkage Estimators of Intercept Parameters of Two Simple Regression Models with Suspected Equal Slopes

Estimators of the intercept parameter of a simple linear regression model involves the slope estimator. In this article, we consider the estimation of the intercept parameters of two linear regression models with normal errors, when it is a priori suspected that the two regression lines are parallel, but in doubt. We also introduce a coefficient of distrust as a measure of degree of lack of trust on the uncertain prior information regarding the equality of two slopes. Three different estimators of the intercept parameters are defined by using the sample data, the non sample uncertain prior information, an appropriate test statistic, and the coefficient of distrust. The relative performances of the unrestricted, shrinkage restricted and shrinkage preliminary test estimators are investigated based on the analyses of the bias and risk functions under quadratic loss. If the prior information is precise and the coefficient of distrust is small, the shrinkage preliminary test estimator overperforms the other estimators. An example based on a medical study is used to illustrate the method.     

Sample size calculation for method validation using linear regression

In this article, we present a method for sample size calculation for studies involving both the intercept and slope parameters of a simple linear regression model. Some methods have been proposed in the literature to determine the adequate sample size. However, they are usually based on the line slope only. We propose a method based on the F statistic that involves both the intercept and the slope parameters of the model. The validation process is conducted by fitting a simple linear regression model and by testing a zero intercept and unity slope hypothesis. Compared to a traditional method and using Monte Carlo simulations, encouraging results attest for the clear superiority of the proposed method. The article ends with a real-life example showing the value of the new method in practice.     

面板数据单位根似然比检验研究

本文采用似然比类检验统计量进行面板单位根检验（简称为LR检验）研究,在局部备择假设成立的条件下,推导了其在无确定项、仅含截距项以及存在线性时间趋势项三种模型下所对应的渐近分布与局部渐近势函数。Monte Carlo模拟结果显示,当面板数据中含确定项（截距项或时间趋势项）时,LR检验水平比LLC和IPS检验水平更接近于给定的显著性检验水平;此外,当面板数据中包含发散个体时,经水平修正后的LR检验势要远远高于经水平修正后的LLC与IPS检验势,其中,经水平修正后的LLC与IPS检验势接近于零。     

Effect of assay measurement error on parameter estimation in concentration–QTc interval modeling

Linear mixed‐effects models (LMEMs) of concentration–double‐delta QTc intervals (QTc intervals corrected for placebo and baseline effects) assume that the concentration measurement error is negligible, which is an incorrect assumption. Previous studies have shown in linear models that independent variable error can attenuate the slope estimate with a corresponding increase in the intercept. Monte Carlo simulation was used to examine the impact of assay measurement error (AME) on the parameter estimates of an LMEM and nonlinear MEM (NMEM) concentration–ddQTc interval model from a ‘typical’ thorough QT study. For the LMEM, the type I error rate was unaffected by assay measurement error. Significant slope attenuation ( > 10%) occurred when the AME exceeded > 40% independent of the sample size. Increasing AME also decreased the between‐subject variance of the slope, increased the residual variance, and had no effect on the between‐subject variance of the intercept. For a typical analytical assay having an assay measurement error of less than 15%, the relative bias in the estimates of the model parameters and variance components was less than 15% in all cases. The NMEM appeared to be more robust to AME error as most parameters were unaffected by measurement error. Monte Carlo simulation was then used to determine whether the simulation–extrapolation method of parameter bias correction could be applied to cases of large AME in LMEMs. For analytical assays with large AME ( > 30%), the simulation–extrapolation method could correct biased model parameter estimates to near‐unbiased levels. Copyright © 2013 John Wiley & Sons, Ltd.     

Confidence Interval Estimation in Ultrastructural Model

The present article proposes a methodology to construct confidence interval for slope parameter and joint confidence region for intercept term and slope parameter in an ultra-structural model with equation error and correlated measurement errors.     

Estimation of Slope for Linear Regression Model with Uncertain Prior Information and Student-t Error

This article considers estimation of the slope parameter of the linear regression model with Student-t errors in the presence of uncertain prior information on the value of the unknown slope. Incorporating uncertain non sample prior information with the sample data the unrestricted, restricted, preliminary test, and shrinkage estimators are defined. The performances of the estimators are compared based on the criteria of unbiasedness and mean squared errors. Both analytical and graphical methods are explored. Although none of the estimators is uniformly superior to the others, if the non sample information is close to its true value, the shrinkage estimator over performs the rest of the estimators.     

A dynamic power prior for borrowing historical data in noninferiority trials with binary endpoint

Traditionally, noninferiority hypotheses have been tested using a frequentist method with a fixed margin. Given that information for the control group is often available from previous studies, it is interesting to consider a Bayesian approach in which information is “borrowed” for the control group to improve efficiency. However, construction of an appropriate informative prior can be challenging. In this paper, we consider a hybrid Bayesian approach for testing noninferiority hypotheses in studies with a binary endpoint. To account for heterogeneity between the historical information and the current trial for the control group, a dynamic P value–based power prior parameter is proposed to adjust the amount of information borrowed from the historical data. This approach extends the simple test‐then‐pool method to allow a continuous discounting power parameter. An adjusted α level is also proposed to better control the type I error. Simulations are conducted to investigate the performance of the proposed method and to make comparisons with other methods including test‐then‐pool and hierarchical modeling. The methods are illustrated with data from vaccine clinical trials.     

A Nonrandomized,Nonconservative Version of the Fisher Exact Test

The Fisher exact test has been unjustly dismissed by some as ‘only conditional,’ whereas it is unconditionally the uniform most powerful test among all unbiased tests, tests of size α and with power greater than its nominal level of significance α. The problem with this truly optimal test is that it requires randomization at the critical value(s) to be of size α. Obviously, in practice, one does not want to conclude that ‘with probability x the we have a statistical significant result.’ Usually, the hypothesis is rejected only if the test statistic's outcome is more extreme than the critical value, reducing the actual size considerably.

The randomized unconditional Fisher exact is constructed (using Neyman–structure arguments) by deriving a conditional randomized test randomizing at critical values c(t) by probabilities γ(t), that both depend on the total number of successes T (the complete-sufficient statistic for the nuisance parameter—the common success probability) conditioned upon.

In this paper, the Fisher exact is approximated by deriving nonrandomized conditional tests with critical region including the critical value only if γ (t) > γ₀, for a fixed threshold value γ₀, such that the size of the unconditional modified test is for all value of the nuisance parameter—the common success probability—smaller, but as close as possible to α. It will be seen that this greatly improves the size of the test as compared with the conservative nonrandomized Fisher exact test.

Size, power, and p value comparison with the (virtual) randomized Fisher exact test, and the conservative nonrandomized Fisher exact, Pearson's chi-square test, with the more competitive mid-p value, the McDonald's modification, and Boschloo's modifications are performed under the assumption of two binomial samples.     

A non linear wavelet based estimator for long memory processes

Two wavelet based estimators are considered in this paper for the two parameters that characterize long range dependence processes. The first one is linear and is based on the statistical properties of the coefficients of a discrete wavelet transform of long range dependence processes. The estimator consists in measuring the slope (related to the long memory parameter) and the intercept (related to the variance of the process) of a linear regression after a discrete wavelet transform is performed (Veitch and Abry, 1999). In this paper its properties are reviewed, and analytic evidence is produced that the linear estimator is applicable only when the second parameter is unknown. To overcome this limitation a non linear wavelet based estimator - that takes into account that the intercept depends on the long memory parameter - is proposed here for the cases in which the second parameter is known or the only parameter of interest is the long memory parameter. Under the same hypothesis assumed for the linear estimator, the non linear estimator is shown to be asymptotically more efficient for the long memory parameter. Numerical simulations show that, even for small data sets, the bias is very small and the variance close to optimal. An application to ATM based Internet traffic is presented.Financial support from the Italian Ministry of University and Scientific Research (MIUR), also in the context of the COFIN 2002 ALINWEB (Algorithms for the Internet and the Web) Project, is gratefully acknowledged.     

Properties of the Cox–Stuart Test for Trend in Application to Hydrological Series: The Simulation Study

The size and power properties of the Cox–Stuart test for detection of a monotonic deterministic trend in hydrological time series are analyzed using the Monte Carlo method. The influence of distribution properties, lengths of series, and trend slopes is studied. Results indicate good size in all cases. The power is high for: length over 60 and strong trend slope, low or medium variation, and medium slope. The power declines if slope and length decrease and if variability increases. The properties are better for skewed distributions than for symmetrical. The test is slightly weaker in comparison to the Mann–Kendall test.     

An alternative to confidence intervals constructed after a Hausman pretest in panel data

Consider panel data modelled by a linear random intercept model that includes a time‐varying covariate. Suppose that our aim is to construct a confidence interval for the slope parameter. Commonly, a Hausman pretest is used to decide whether this confidence interval is constructed using the random effects model or the fixed effects model. This post‐model‐selection confidence interval has the attractive features that it (a) is relatively short when the random effects model is correct and (b) reduces to the confidence interval based on the fixed effects model when the data and the random effects model are highly discordant. However, this confidence interval has the drawbacks that (i) its endpoints are discontinuous functions of the data and (ii) its minimum coverage can be far below its nominal coverage probability. We construct a new confidence interval that possesses these attractive features, but does not suffer from these drawbacks. This new confidence interval provides an intermediate between the post‐model‐selection confidence interval and the confidence interval obtained by always using the fixed effects model. The endpoints of the new confidence interval are smooth functions of the Hausman test statistic, whereas the endpoints of the post‐model‐selection confidence interval are discontinuous functions of this statistic.     

A note on millers's empirical weights for heteroscedastic linear regression

For heteroscedastic simple linear regression when the variances are proportional to a power of the mean of the response variable, Miller (1986) recommends the following procedure: do a weighted least squares regression with the weights (empirical weights) estimated by the inverse of the appropriate power of the response variable. The practical appeal of this approach is its simplicity.

In this article some of the consequences of this simple procedure are considered. Specifically, the effect of this procedure on the bias of the point estimators of the regression coefficients and on the coverage probabilities of their corresponding confidence intervals is examined. It is found that the performance of the process of employing empirical weights in a weighted least squares regression depends on : (1) the particular regression parameter (slope or intercept) of interest, (2) the appropriate power of the mean of the response variable involved, and (3) the amount of variation in the data about the true regression line.     

Testing the difference of two exponential means using generalized p-values

There are no exact fixed-level tests for testing the null hypothesis that the difference of two exponential means is less than or equal to a prespecified value θ₀. For this testing problem, there are several approximate testing procedures available in the literature. Using an extended definition of p-values, Tsui and Weerahandi (1989) gave an exact significance test for this testing problem. In this paper, the performance of that procedure is investigated and is compared with approximate procedures. A size and power comparison is carried out using a simulation study. Its findings show that the test based on the generalized p-value guarantees the intended size and that it is either as good as or outperforms approximate procedures available in the literature, both in power and in size.     

The Use of Permutation Tests for Variance Components in Linear Mixed Models

Standard asymptotic chi-square distribution of the likelihood ratio and score statistics under the null hypothesis does not hold when the parameter value is on the boundary of the parameter space. In mixed models it is of interest to test for a zero random effect variance component. Some available tests for the variance component are reviewed and a new test within the permutation framework is presented. The power and significance level of the different tests are investigated by means of a Monte Carlo simulation study. The proposed test has a significance level closer to the nominal one and it is more powerful.     

A self-adjusted weighted likelihood ratio test for global clustering of disease

Compared to tests for localized clusters, the tests for global clustering only collect evidence for clustering throughout the study region without evaluating the statistical significance of the individual clusters. The weighted likelihood ratio (WLR) test based on the weighted sum of likelihood ratios represents an important class of tests for global clustering. Song and Kulldorff (Likelihood based tests for spatial randomness. Stat Med. 2006;25(5):825–839) developed a wide variety of weight functions with the WLR test for global clustering. However, these weight functions are often defined based on the cell population size or the geographic information such as area size and distance between cells. They do not make use of the information from the observed count, although the likelihood ratio of a potential cluster depends on both the observed count and its population size. In this paper, we develop a self-adjusted weight function to directly allocate weights onto the likelihood ratios according to their values. The power of the test was evaluated and compared with existing methods based on a benchmark data set. The comparison results favour the suggested test especially under global chain clustering models.     

A study of moments and likelihood estimators of the odd Weibull distribution

The odd Weibull distribution is a three-parameter generalization of the Weibull and the inverse Weibull distributions having rich density and hazard shapes for modeling lifetime data. This paper explored the odd Weibull parameter regions having finite moments and examined the relation to some well-known distributions based on skewness and kurtosis functions. The existence of maximum likelihood estimators have shown with complete data for any sample size. The proof for the uniqueness of these estimators is given only when the absolute value of the second shape parameter is between zero and one. Furthermore, elements of the Fisher information matrix are obtained based on complete data using a single integral representation which have shown to exist for any parameter values. The performance of the odd Weibull distribution over various density and hazard shapes is compared with generalized gamma distribution using two different test statistics. Finally, analysis of two data sets has been performed for illustrative purposes.     

Tests for Parameter Instability in Regressions with 1(1) Processes

This article derives the large-sample distributions of Lagrange multiplier (LM) tests for parameter instability against several alternatives of interest in the context of cointegrated regression models. The fully modified estimator of Phillips and Hansen is extended to cover general models with stochastic and deterministic trends. The test statistics considered include the SupF test of Quandt, as well as the LM tests of Nyblom and of Nabeya and Tanaka. It is found that the asymptotic distributions depend on the nature of the regressor processes—that is, if the regressors are stochastic or deterministic trends. The distributions are noticeably different from the distributions when the data are weakly dependent. It is also found that the lack of cointegration is a special case of the alternative hypothesis considered (an unstable intercept), so the tests proposed here may also be viewed as a test of the null of cointegration against the alternative of no cointegration. The tests are applied to three data sets—an aggregate consumption function, a present value model of stock prices and dividends, and the term structure of interest rates.