Estimating the parameters of the linear compartment model

In this paper we consider the linear compartment model and consider the estimation procedures of the different parameters. We discuss a method to obtain the initial estimators, which can be used for any iterative procedures to obtain the least-squares estimators. Four different types of confidence intervals have been discussed and they have been compared by computer simulations. We propose different methods to estimate the number of components of the linear compartment model. One data set has been used to see how the different methods work in practice.     

Model Selection Criterion Based on the Multivariate Quasi‐Likelihood for Generalized Estimating Equations

The generalized estimating equations (GEE) approach has attracted considerable interest for the analysis of correlated response data. This paper considers the model selection criterion based on the multivariate quasi‐likelihood (MQL) in the GEE framework. The GEE approach is closely related to the MQL. We derive a necessary and sufficient condition for the uniqueness of the risk function based on the MQL by using properties of differential geometry. Furthermore, we establish a formal derivation of model selection criterion as an asymptotically unbiased estimator of the prediction risk under this condition, and we explicitly take into account the effect of estimating the correlation matrix used in the GEE procedure.     

Estimating the Basic Reproductive Number in the General Epidemic Model with an Unknown Initial Number of Susceptible Individuals

Abstract. In any epidemic, there may exist an unidentified subpopulation which might be naturally immune or isolated and who will not be involved in the transmission of the disease. Estimation of key parameters, for example, the basic reproductive number, without accounting for this possibility would underestimate the severity of the epidemics. Here, we propose a procedure to estimate the basic reproductive number ( R ₀ ) in an epidemic model with an unknown initial number of susceptibles. The infection process is usually not completely observed, but is reconstructed by a kernel‐smoothing method under a counting process framework. Simulation is used to evaluate the performance of the estimators for major epidemics. We illustrate the procedure using the Abakaliki smallpox data.     

The Estimation of Compensating Wage Differentials: Lessons From the Deadliest Catch

ABSTRACT

I use longitudinal survey data from commercial fishing deckhands in the Alaskan Bering Sea to provide new insights on empirical methods commonly used to estimate compensating wage differentials and the value of statistical life (VSL). The unique setting exploits intertemporal variation in fatality rates and wages within worker-vessel pairs caused by a combination of weather patterns and policy changes, allowing identification of parameters and biases that it has only been possible to speculate about in more general settings. I show that estimation strategies common in the literature produce biased estimates in this setting, and decompose the bias components due to latent worker, establishment, and job-match heterogeneity. The estimates also remove the confounding effects of endogenous job mobility and dynamic labor market search, narrowing a conceptual gap between search-based hedonic wage theory and its empirical applications. I find that workers’ marginal aversion to fatal risk falls as risk levels rise, which suggests complementarities in the benefits of public safety policies. Supplementary materials for this article are available online.     

Estimating Average Worth of the Selected Subset from Two-Parameter Exponential Populations

ABSTRACT

Suppose independent random samples are available from k(k ≥ 2) exponential populations ∏₁,…,∏ _k with a common location θ and scale parameters σ₁,…,σ _k , respectively. Let X _i and Y _i denote the minimum and the mean, respectively, of the ith sample, and further let X = min{X ₁,…, X _k } and T _i  = Y _i  ? X; i = 1,…, k. For selecting a nonempty subset of {∏₁,…,∏ _k } containing the best population (the one associated with max{σ₁,…,σ _k }), we use the decision rule which selects ∏ _i if T _i  ≥ c max{T ₁,…,T _k }, i = 1,…, k. Here 0 < c ≤ 1 is chosen so that the probability of including the best population in the selected subset is at least P* (1/k ≤ P* < 1), a pre-assigned level. The problem is to estimate the average worth W of the selected subset, the arithmetic average of means of selected populations. In this article, we derive the uniformly minimum variance unbiased estimator (UMVUE) of W. The bias and risk function of the UMVUE are compared numerically with those of analogs of the best affine equivariant estimator (BAEE) and the maximum likelihood estimator (MLE).     

Nonparametric Estimation of the Number of Drug Users in Hong Kong Using Repeated Multiple Lists

We update a previous approach to the estimation of the size of an open population when there are multiple lists at each time point. Our motivation is 35 years of longitudinal data on the detection of drug users by the Central Registry of Drug Abuse in Hong Kong. We develop a two‐stage smoothing spline approach. This gives a flexible and easily implemented alternative to the previous method which was based on kernel smoothing. The new method retains the property of reducing the variability of the individual estimates at each time point. We evaluate the new method by means of a simulation study that includes an examination of the effects of variable selection. The new method is then applied to data collected by the Central Registry of Drug Abuse. The parameter estimates obtained are compared with the well known Jolly–Seber estimates based on single capture methods.     

Stochastic EM algorithm of a finite mixture model from hurdle Poisson distribution with missing responses

ABSTRACT

In this article, a finite mixture model of hurdle Poisson distribution with missing outcomes is proposed, and a stochastic EM algorithm is developed for obtaining the maximum likelihood estimates of model parameters and mixing proportions. Specifically, missing data is assumed to be missing not at random (MNAR)/non ignorable missing (NINR) and the corresponding missingness mechanism is modeled through probit regression. To improve the algorithm efficiency, a stochastic step is incorporated into the E-step based on data augmentation, whereas the M-step is solved by the method of conditional maximization. A variation on Bayesian information criterion (BIC) is also proposed to compare models with different number of components with missing values. The considered model is a general model framework and it captures the important characteristics of count data analysis such as zero inflation/deflation, heterogeneity as well as missingness, providing us with more insight into the data feature and allowing for dispersion to be investigated more fully and correctly. Since the stochastic step only involves simulating samples from some standard distributions, the computational burden is alleviated. Once missing responses and latent variables are imputed to replace the conditional expectation, our approach works as part of a multiple imputation procedure. A simulation study and a real example illustrate the usefulness and effectiveness of our methodology.     

Adaptive estimation of the conditional cumulative distribution function from current status data

Consider a positive random variable of interest Y depending on a covariate X, and a random observation time T independent of Y given X. Assume that the only knowledge available about Y is its current status at time T  : δ=_I{Y≤T}$\delta ={\mathbb{I}}_{\{Y\le T\}}$ with I$\mathbb{I}$ the indicator function. This paper presents a procedure to estimate the conditional cumulative distribution function F of Y given X   from an independent identically distributed sample of (X,T,δ)$(X,T,\delta )$.     

Estimating prediction error in microarray classification: Modifications of the 0.632+ bootstrap when ${\bf n} < {\bf p}$

We are interested in estimating prediction error for a classification model built on high dimensional genomic data when the number of genes (p) greatly exceeds the number of subjects (n). We examine a distance argument supporting the conventional 0.632+ bootstrap proposed for the $n > p$ scenario, modify it for the $n < p$ situation and develop learning curves to describe how the true prediction error varies with the number of subjects in the training set. The curves are then applied to define adjusted resampling estimates for the prediction error in order to achieve a balance in terms of bias and variability. The adjusted resampling methods are proposed as counterparts of the 0.632+ bootstrap when $n < p$ , and are found to improve on the 0.632+ bootstrap and other existing methods in the microarray study scenario when the sample size is small and there is some level of differential expression. The Canadian Journal of Statistics 41: 133–150; 2013 © 2012 Statistical Society of Canada