Partly linear models on Riemannian manifolds

In partly linear models, the dependence of the response y on (x ^T, t) is modeled through the relationship y=x ^T β+g(t)+?, where ? is independent of (x ^T, t). We are interested in developing an estimation procedure that allows us to combine the flexibility of the partly linear models, studied by several authors, but including some variables that belong to a non-Euclidean space. The motivating application of this paper deals with the explanation of the atmospheric SO₂ pollution incidents using these models when some of the predictive variables belong in a cylinder. In this paper, the estimators of β and g are constructed when the explanatory variables t take values on a Riemannian manifold and the asymptotic properties of the proposed estimators are obtained under suitable conditions. We illustrate the use of this estimation approach using an environmental data set and we explore the performance of the estimators through a simulation study.     

Functional analysis of high-content high-throughput imaging data

High-content automated imaging platforms allow the multiplexing of several targets simultaneously to generate multi-parametric single-cell data sets over extended periods of time. Typically, standard simple measures such as mean value of all cells at every time point are calculated to summarize the temporal process, resulting in loss of time dynamics of the single cells. Multiple experiments are performed but observation time points are not necessarily identical, leading to difficulties when integrating summary measures from different experiments. We used functional data analysis to analyze continuous curve data, where the temporal process of a response variable for each single cell can be described using a smooth curve. This allows analyses to be performed on continuous functions, rather than on original discrete data points. Functional regression models were applied to determine common temporal characteristics of a set of single cell curves and random effects were employed in the models to explain variation between experiments. The aim of the multiplexing approach is to simultaneously analyze the effect of a large number of compounds in comparison to control to discriminate between their mode of action. Functional principal component analysis based on T-statistic curves for pairwise comparison to control was used to study time-dependent compound effects.     

Fast and robust bootstrap

In this paper we review recent developments on a bootstrap method for robust estimators which is computationally faster and more resistant to outliers than the classical bootstrap. This fast and robust bootstrap method is, under reasonable regularity conditions, asymptotically consistent. We describe the method in general and then consider its application to perform inference based on robust estimators for the linear regression and multivariate location-scatter models. In particular, we study confidence and prediction intervals and tests of hypotheses for linear regression models, inference for location-scatter parameters and principal components, and classification error estimation for discriminant analysis.     

Shape-Constrained Kernel-Weighted Least Squares: Estimating Production Functions for Chilean Manufacturing Industries

ABSTRACT

In this article, we examine a novel way of imposing shape constraints on a local polynomial kernel estimator. The proposed approach is referred to as shape constrained kernel-weighted least squares (SCKLS). We prove uniform consistency of the SCKLS estimator with monotonicity and convexity/concavity constraints and establish its convergence rate. In addition, we propose a test to validate whether shape constraints are correctly specified. The competitiveness of SCKLS is shown in a comprehensive simulation study. Finally, we analyze Chilean manufacturing data using the SCKLS estimator and quantify production in the plastics and wood industries. The results show that exporting firms have significantly higher productivity.     

On asymptotic distribution of prediction in functional linear regression

There has been substantial recent attention on problems involving a functional linear regression model with scalar response. Among them, there have been few works dealing with asymptotic distribution of prediction in functional linear regression models. In recent literature, the centeral limit theorem for prediction has been discussed, but the proof and conditions under which the random bias terms for a fixed predictor converge to zero have been ignored so that the impact of these terms on the convergence of the prediction has not been well understood. Clarifying the proof and conditions under which the bias terms converge to zero, we show that the asymptotic distribution of the prediction is normal. Furthermore, we have derived those results related to other terms that already obtained by others, under milder conditions. Finally, we conduct a simulation study to investigate performance of the asymptotic distribution under various parameter settings.     

On nonparametric regression estimators based on regression quantiles

In the ciassical regression model Y_i=h(x_i) + ? _i, i=1,…,n, Cheng (1984) introduced linear combinations of regression quantiles as a new class of estimators for the unknown regression function h(x). The asymptotic properties studied in Cheng (1984) are reconsidered. We obtain a sharper scrong consistency rate and we improve on the conditions for asymptotic normality by proving a new result on the remainder term in the Bahadur representation for regression quantiles.