Bivariate zero-inflated negative binomial regression model with applications

Count data often display excessive number of zero outcomes than are expected in the Poisson regression model. The zero-inflated Poisson regression model has been suggested to handle zero-inflated data, whereas the zero-inflated negative binomial (ZINB) regression model has been fitted for zero-inflated data with additional overdispersion. For bivariate and zero-inflated cases, several regression models such as the bivariate zero-inflated Poisson (BZIP) and bivariate zero-inflated negative binomial (BZINB) have been considered. This paper introduces several forms of nested BZINB regression model which can be fitted to bivariate and zero-inflated count data. The mean–variance approach is used for comparing the BZIP and our forms of BZINB regression model in this study. A similar approach was also used by past researchers for defining several negative binomial and zero-inflated negative binomial regression models based on the appearance of linear and quadratic terms of the variance function. The nested BZINB regression models proposed in this study have several advantages; the likelihood ratio tests can be performed for choosing the best model, the models have flexible forms of marginal mean–variance relationship, the models can be fitted to bivariate zero-inflated count data with positive or negative correlations, and the models allow additional overdispersion of the two dependent variables.     

Bayesian estimation and case influence diagnostics for the zero-inflated negative binomial regression model

In recent years, there has been considerable interest in regression models based on zero-inflated distributions. These models are commonly encountered in many disciplines, such as medicine, public health, and environmental sciences, among others. The zero-inflated Poisson (ZIP) model has been typically considered for these types of problems. However, the ZIP model can fail if the non-zero counts are overdispersed in relation to the Poisson distribution, hence the zero-inflated negative binomial (ZINB) model may be more appropriate. In this paper, we present a Bayesian approach for fitting the ZINB regression model. This model considers that an observed zero may come from a point mass distribution at zero or from the negative binomial model. The likelihood function is utilized to compute not only some Bayesian model selection measures, but also to develop Bayesian case-deletion influence diagnostics based on q-divergence measures. The approach can be easily implemented using standard Bayesian software, such as WinBUGS. The performance of the proposed method is evaluated with a simulation study. Further, a real data set is analyzed, where we show that ZINB regression models seems to fit the data better than the Poisson counterpart.     

Marginal zero-inflated regression models for count data

Data sets with excess zeroes are frequently analyzed in many disciplines. A common framework used to analyze such data is the zero-inflated (ZI) regression model. It mixes a degenerate distribution with point mass at zero with a non-degenerate distribution. The estimates from ZI models quantify the effects of covariates on the means of latent random variables, which are often not the quantities of primary interest. Recently, marginal zero-inflated Poisson (MZIP; Long et al. [A marginalized zero-inflated Poisson regression model with overall exposure effects. Stat. Med. 33 (2014), pp. 5151–5165]) and negative binomial (MZINB; Preisser et al., 2016) models have been introduced that model the mean response directly. These models yield covariate effects that have simple interpretations that are, for many applications, more appealing than those available from ZI regression. This paper outlines a general framework for marginal zero-inflated models where the latent distribution is a member of the exponential dispersion family, focusing on common distributions for count data. In particular, our discussion includes the marginal zero-inflated binomial (MZIB) model, which has not been discussed previously. The details of maximum likelihood estimation via the EM algorithm are presented and the properties of the estimators as well as Wald and likelihood ratio-based inference are examined via simulation. Two examples presented illustrate the advantages of MZIP, MZINB, and MZIB models for practical data analysis.     

随机效应零膨胀索赔次数回归模型

索赔频率预测是非寿险费率厘定的重要组成部分。最常使用的索赔频率预测模型是泊松回归和负二项回归,以及与它们相对应的零膨胀回归模型。但是,当索赔次数观察值既具有零膨胀特征,又存在组内相依结构时,上述模型都不能很好地拟合实际数据。为此,本文在泊松分布、负二项分布、广义泊松分布、P型负二项分布等条件下分别建立了随机效应零膨胀损失次数回归模型。为了改进模型的预测效果,对于连续型的解释变量,还引入了二次平滑项,并建立了结构性零比例与解释变量之间的回归关系。基于一组实际索赔次数数据的实证分析结果表明,该模型可以显著改进现有模型的拟合效果。     

Functional Form for the Zero-Inflated Generalized Poisson Regression Model

The generalized Poisson (GP) regression is an increasingly popular approach for modeling overdispersed as well as underdispersed count data. Several parameterizations have been performed for the GP regression, and the two well known models, the GP-1 and the GP-2, have been applied. The GP-P regression, which has been recently proposed, has the advantage of nesting the GP-1 and the GP-2 parametrically, besides allowing the statistical tests of the GP-1 and the GP-2 against a more general alternative. In several cases, count data often have excessive number of zero outcomes than are expected in the Poisson. This zero-inflation phenomenon is a specific cause of overdispersion, and the zero-inflated Poisson (ZIP) regression model has been proposed. However, if the data continue to suggest additional overdispersion, the zero-inflated negative binomial (ZINB-1 and ZINB-2) and the zero-inflated generalized Poisson (ZIGP-1 and ZIGP-2) regression models have been considered as alternatives. This article proposes a functional form of the ZIGP which mixes a distribution degenerate at zero with a GP-P distribution. The suggested model has the advantage of nesting the ZIP and the two well known ZIGP (ZIGP-1 and ZIGP-2) regression models, besides allowing the statistical tests of the ZIGP-1 and the ZIGP-2 against a more general alternative. The ZIP and the functional form of the ZIGP regression models are fitted, compared and tested on two sets of count data; the Malaysian insurance claim data and the German healthcare data.     

A Bayesian Approach for Zero-Inflated Count Regression Models by Using the Reversible Jump Markov Chain Monte Carlo Method and an Application

In this study, estimation of the parameters of the zero-inflated count regression models and computations of posterior model probabilities of the log-linear models defined for each zero-inflated count regression models are investigated from the Bayesian point of view. In addition, determinations of the most suitable log-linear and regression models are investigated. It is known that zero-inflated count regression models cover zero-inflated Poisson, zero-inflated negative binomial, and zero-inflated generalized Poisson regression models. The classical approach has some problematic points but the Bayesian approach does not have similar flaws. This work points out the reasons for using the Bayesian approach. It also lists advantages and disadvantages of the classical and Bayesian approaches. As an application, a zoological data set, including structural and sampling zeros, is used in the presence of extra zeros. In this work, it is observed that fitting a zero-inflated negative binomial regression model creates no problems at all, even though it is known that fitting a zero-inflated negative binomial regression model is the most problematic procedure in the classical approach. Additionally, it is found that the best fitting model is the log-linear model under the negative binomial regression model, which does not include three-way interactions of factors.     

Zero-inflated Poisson and negative binomial integer-valued GARCH models

Zero inflation means that the proportion of 0's of a model is greater than the proportion of 0's of the corresponding Poisson model, which is a common phenomenon in count data. To model the zero-inflated characteristic of time series of counts, we propose zero-inflated Poisson and negative binomial INGARCH models, which are useful and flexible generalizations of the Poisson and negative binomial INGARCH models, respectively. The stationarity conditions and the autocorrelation function are given. Based on the EM algorithm, the estimating procedure is simple and easy to be implemented. A simulation study shows that the estimation method is accurate and reliable as long as the sample size is reasonably large. A real data example leads to superior performance of the proposed models compared with other competitive models in the literature.     

GEE-based zero-inflated generalized Poisson model for clustered over or under-dispersed count data

The zero-inflated regression models such as zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB) or zero-inflated generalized Poisson (ZIGP) regression models can model the count data with excess zeros. The ZINB model can handle over-dispersed and the ZIGP model can handle the over or under-dispersed count data with excess zeros as well. Moreover, the count data may be correlated because of data collection procedure or special study design. The clustered sampling approach is one of the examples in which the correlation among subjects could be defined. In such situations, a marginal model using generalized estimating equation (GEE) approach can incorporate these correlations and lead up to the relationships at the population level. In this study, the GEE-based zero-inflated generalized Poisson regression model was proposed to fit over and under-dispersed clustered count data with excess zeros.     

Zero-spiked regression models generated by gamma random variables with application in the resin oil production

Zero-inflated data are more frequent when the data represent counts. However, there are practical situations in which continuous data contain an excess of zeros. In these cases, the zero-inflated Poisson, binomial or negative binomial models are not suitable. In order to reduce this gap, we propose the zero-spiked gamma-Weibull (ZSGW) model by mixing a distribution which is degenerate at zero with the gamma-Weibull distribution, which has positive support. The model attempts to estimate simultaneously the effects of explanatory variables on the response variable and the zero-spiked. We consider a frequentist analysis and a non-parametric bootstrap for estimating the parameters of the ZSGW regression model. We derive the appropriate matrices for assessing local influence on the model parameters. We illustrate the performance of the proposed regression model by means of a real data set (copaiba oil resin production) from a study carried out at the Department of Forest Science of the Luiz de Queiroz School of Agriculture, University of São Paulo. Based on the ZSGW regression model, we determine the explanatory variables that can influence the excess of zeros of the resin oil production and identify influential observations. We also prove empirically that the proposed regression model can be superior to the zero-adjusted inverse Gaussian regression model to fit zero-inflated positive continuous data.     

Estimation of Median in Two-Phase Sampling Using Two Auxiliary Variables

In recent years, zero-inflated count data models, such as zero-inflated Poisson (ZIP) models, are widely used as the count data with extra zeros are very common in many practical problems. In order to model the correlated count data which are either clustered or repeated and to assess the effects of continuous covariates or of time scales in a flexible way, a class of semiparametric mixed-effects models for zero-inflated count data is considered. In this article, we propose a fully Bayesian inference for such models based on a data augmentation scheme that reflects both random effects of covariates and mixture of zero-inflated distribution. A computational efficient MCMC method which combines the Gibbs sampler and M-H algorithm is implemented to obtain the estimate of the model parameters. Finally, a simulation study and a real example are used to illustrate the proposed methodologies.     

零膨胀计数数据的联合建模及变量选择

零膨胀计数数据破坏了泊松分布的方差-均值关系，可由取值服从泊松分布的数据和取值为零(退化分布)的数据各占一定比例所构成的混合分布所解释。本文基于自适应弹性网技术， 研究了零膨胀计数数据的联合建模及变量选择问题.对于零膨胀泊松分布，引入潜变量，构造出零膨胀泊松模型的完全似然, 其中由零膨胀部分和泊松部分两项组成.考虑到协变量可能存在共线性和稀疏性，通过对似然函数加自适应弹性网惩罚得到目标函数,然后利用EM算法得到回归系数的稀疏估计量，并用贝叶斯信息准则BIC来确定最优调节参数.本文也给出了估计量的大样本性质的理论证明和模拟研究，最后把所提出的方法应用到实际问题中。     

Regression for doubly inflated multivariate Poisson distributions

Dependent multivariate count data occur in several research studies. These data can be modelled by a multivariate Poisson or Negative binomial distribution constructed using copulas. However, when some of the counts are inflated, that is, the number of observations in some cells are much larger than other cells, then the copula-based multivariate Poisson (or Negative binomial) distribution may not fit well and it is not an appropriate statistical model for the data. There is a need to modify or adjust the multivariate distribution to account for the inflated frequencies. In this article, we consider the situation where the frequencies of two cells are higher compared to the other cells and develop a doubly inflated multivariate Poisson distribution function using multivariate Gaussian copula. We also discuss procedures for regression on covariates for the doubly inflated multivariate count data. For illustrating the proposed methodologies, we present real data containing bivariate count observations with inflations in two cells. Several models and linear predictors with log link functions are considered, and we discuss maximum likelihood estimation to estimate unknown parameters of the models.     

Score test for testing zero-inflated Poisson regression against zero-inflated generalized Poisson alternatives

In several cases, count data often have excessive number of zero outcomes. This zero-inflated phenomenon is a specific cause of overdispersion, and zero-inflated Poisson regression model (ZIP) has been proposed for accommodating zero-inflated data. However, if the data continue to suggest additional overdispersion, zero-inflated negative binomial (ZINB) and zero-inflated generalized Poisson (ZIGP) regression models have been considered as alternatives. This study proposes the score test for testing ZIP regression model against ZIGP alternatives and proves that it is equal to the score test for testing ZIP regression model against ZINB alternatives. The advantage of using the score test over other alternative tests such as likelihood ratio and Wald is that the score test can be used to determine whether a more complex model is appropriate without fitting the more complex model. Applications of the proposed score test on several datasets are also illustrated.     

Analyzing clustered count data with a cluster-specific random effect zero-inflated Conway–Maxwell–Poisson distribution

Count data analysis techniques have been developed in biological and medical research areas. In particular, zero-inflated versions of parametric count distributions have been used to model excessive zeros that are often present in these assays. The most common count distributions for analyzing such data are Poisson and negative binomial. However, a Poisson distribution can only handle equidispersed data and a negative binomial distribution can only cope with overdispersion. However, a Conway–Maxwell–Poisson (CMP) distribution [4] can handle a wide range of dispersion. We show, with an illustrative data set on next-generation sequencing of maize hybrids, that both underdispersion and overdispersion can be present in genomic data. Furthermore, the maize data set consists of clustered observations and, therefore, we develop inference procedures for a zero-inflated CMP regression that incorporates a cluster-specific random effect term. Unlike the Gaussian models, the underlying likelihood is computationally challenging. We use a numerical approximation via a Gaussian quadrature to circumvent this issue. A test for checking zero-inflation has also been developed in our setting. Finite sample properties of our estimators and test have been investigated by extensive simulations. Finally, the statistical methodology has been applied to analyze the maize data mentioned before.     

Attribute Charts for Zero-Inflated Processes

The classical Shewhart c-chart and p-chart which are constructed based on the Poisson and binomial distributions are inappropriate in monitoring zero-inflated counts. They tend to underestimate the dispersion of zero-inflated counts and subsequently lead to higher false alarm rate in detecting out-of-control signals. Another drawback of these charts is that their 3-sigma control limits, evaluated based on the asymptotic normality assumption of the attribute counts, have a systematic negative bias in their coverage probability. We recommend that the zero-inflated models which account for the excess number of zeros should first be fitted to the zero-inflated Poisson and binomial counts. The Poisson parameter λ estimated from a zero-inflated Poisson model is then used to construct a one-sided c-chart with its upper control limit constructed based on the Jeffreys prior interval that provides good coverage probability for λ. Similarly, the binomial parameter p estimated from a zero-inflated binomial model is used to construct a one-sided np-chart with its upper control limit constructed based on the Jeffreys prior interval or Blyth–Still interval of the binomial proportion p. A simple two-of-two control rule is also recommended to improve further on the performance of these two proposed charts.     

A doubly-inflated Poisson regression for correlated count data

Count data have emerged in many applied research areas. In recent years, there has been a considerable interest in models for count data. In modelling such data, it is common to face a large frequency of zeroes. The data are regarded as zero-inflated when the frequency of observed zeroes is larger than what is expected from a theoretical distribution such as Poisson distribution, as a standard model for analysing count data. Data analysis, using the simple Poisson model, may lead to over-dispersion. Several classes of different mixture models were proposed for handling zero-inflated data. But they do not apply to cases when inflated counts happen at some other points, in addition to zero. In these cases, a doubly-inflated Poisson model has been suggested which only be used for cross-sectional data and cannot consider correlations between observations. However, correlated count data have a large application, especially in the health and medical fields. The present study aims to introduce a Doubly-Inflated Poisson models with random effect for correlated doubly-inflated data. Then, the best performance of the proposed method is shown via different simulation scenarios. Finally, the proposed model is applied to a dental study.KEYWORDS: Count data, doubly-inflated, Poisson regression, zero-inflated, correlated data     

Zero-inflated compound Poisson distributions in integer-valued GARCH models

In this paper we introduce a wide class of integer-valued stochastic processes that allows to take into consideration, simultaneously, relevant characteristics observed in count data namely zero inflation, overdispersion and conditional heteroscedasticity. This class includes, in particular, the compound Poisson, the zero-inflated Poisson and the zero-inflated negative binomial INGARCH models, recently proposed in literature. The main probabilistic analysis of this class of processes is here developed. Precisely, first- and second-order stationarity conditions are derived, the autocorrelation function is deduced and the strict stationarity is established in a large subclass. We also analyse in a particular model the existence of higher-order moments and deduce the explicit form for the first four cumulants, as well as its skewness and kurtosis.     

Zero-inflated sum of Conway-Maxwell-Poissons (ZISCMP) regression

While excess zeros are often thought to cause data over-dispersion (i.e. when the variance exceeds the mean), this implication is not absolute. One should instead consider a flexible class of distributions that can address data dispersion along with excess zeros. This work develops a zero-inflated sum-of-Conway-Maxwell-Poissons (ZISCMP) regression as a flexible analysis tool to model count data that express significant data dispersion and contain excess zeros. This class of models contains several special case zero-inflated regressions, including zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB), zero-inflated binomial (ZIB), and the zero-inflated Conway-Maxwell-Poisson (ZICMP). Through simulated and real data examples, we demonstrate class flexibility and usefulness. We further utilize it to analyze shark species data from Australia's Great Barrier Reef to assess the environmental impact of human action on the number of various species of sharks.     

Testing overdispersion in the zero-inflated Poisson model

The zero-inflated negative binomial (ZINB) model is used to account for commonly occurring overdispersion detected in data that are initially analyzed under the zero-inflated Poisson (ZIP) model. Tests for overdispersion (Wald test, likelihood ratio test [LRT], and score test) based on ZINB model for use in ZIP regression models have been developed. Due to similarity to the ZINB model, we consider the zero-inflated generalized Poisson (ZIGP) model as an alternate model for overdispersed zero-inflated count data. The score test has an advantage over the LRT and the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis. This paper proposes score tests for overdispersion based on the ZIGP model and illustrates that the derived score statistics are exactly the same as the score statistics under the ZINB model. A simulation study indicates the proposed score statistics are preferred to other tests for higher empirical power. In practice, based on the approximate mean–variance relationship in the data, the ZINB or ZIGP model can be considered, and a formal score test based on asymptotic standard normal distribution can be employed for assessing overdispersion in the ZIP model. We provide an example to illustrate the procedures for data analysis.     

Distribution-free inference of zero-inflated binomial data for longitudinal studies

Count responses with structural zeros are very common in medical and psychosocial research, especially in alcohol and HIV research, and the zero-inflated Poisson (ZIP) and zero-inflated negative binomial models are widely used for modeling such outcomes. However, as alcohol drinking outcomes such as days of drinkings are counts within a given period, their distributions are bounded above by an upper limit (total days in the period) and thus inherently follow a binomial or zero-inflated binomial (ZIB) distribution, rather than a Poisson or ZIP distribution, in the presence of structural zeros. In this paper, we develop a new semiparametric approach for modeling ZIB-like count responses for cross-sectional as well as longitudinal data. We illustrate this approach with both simulated and real study data.