A Longitudinal Examination of Physiological Regulation in Cocaine‐Exposed Infants Across the First 7 Months of Life

This study examined the association between prenatal exposure to cocaine and physiological regulation across the first 7 months of age. Measures of respiratory sinus arrhythmia (RSA) were obtained from 169 (82 cocaine‐exposed and 87 nonexposed) infants during baseline periods at 1 month and 7 months of age and during tasks designed to elicit positive and negative affect at 7 months of age. After controlling for maternal age, gestational age, and obstetrical risk, structural equation modeling indicated that the association between prenatal exposure to cocaine and baseline RSA at 7 months of age was direct even in the presence of an indirect effect through baseline RSA at 1 month of age. There were no indirect effects through maternal affect during mother‐infant interactions assessed at 1 month of age. Analyses also indicated a direct association between prenatal exposure to cocaine and RSA regulation to negative affect at 7 months of age.     

The Association Between Cigarette Smoking During Pregnancy and Maternal Behavior During the Neonatal Period

This study examined the association between maternal smoking during pregnancy and maternal behavior during mother‐infant interactions during the neonatal period. Participants included 84 mother‐infant dyads (43 cigarette‐exposed and 41 nonexposed) who were recruited after birth and assessed at 2 to 4 weeks of infant age. Results indicated that mothers who smoked during pregnancy had higher levels of maternal insensitivity (MI) and lower levels of maternal warmth (MW) during interactions with their infant even after controlling for demographics and pregnancy alcohol use. Maternal anxiety and hostility mediated the association between smoking and MI and maternal anger mediated the association between smoking and reduced MW. In addition, there was an interaction between infant gender and maternal smoking for MW with smokers displaying less warmth to boys during interactions.     

Maternal Lifetime Trauma Exposure,Prenatal Cortisol,and Infant Negative Affectivity

Little research has examined the impact of maternal lifetime trauma exposure on infant temperament. We examined associations between maternal trauma history and infant negative affectivity and modification by prenatal cortisol exposure in a sociodemographically diverse sample of mother–infant dyads. During pregnancy, mothers completed measures of lifetime trauma exposure and current stressors. Third‐trimester cortisol output was assessed from maternal hair. When infants were 6 months old, mothers completed the Infant Behavior Questionnaire‐Revised. In analyses that controlled for infant sex and maternal age, education, race/ethnicity, and stress during pregnancy, greater maternal trauma exposure was associated with increased infant distress to limitations and sadness. Higher and lower prenatal cortisol exposure modified the magnitude and direction of association between maternal trauma history and infant rate of recovery from arousal. The association between maternal trauma history and infant distress to limitations was somewhat stronger among infants exposed to higher levels of prenatal cortisol. The analyses suggested that maternal lifetime trauma exposure is associated with several domains of infant negative affectivity independently of maternal stress exposures during pregnancy and that some of these associations may be modified by prenatal cortisol exposure. The findings have implications for understanding the intergenerational impact of trauma exposure on child developmental outcomes.     

Contingency Learning and Reactivity in Preterm and Full‐Term Infants at 3 Months

Learning difficulties in preterm infants are thought to reflect impairment in arousal regulation. We examined relationships among gestational age, learning speed, and behavioral and physiological reactivity in 55 preterm and 49 full‐term infants during baseline, contingency, and nonreinforcement phases of a conjugate mobile paradigm at 3 months corrected age. For all infants, negative affect, looking duration, and heart rate levels increased during contingency and nonreinforcement phases, whereas respiratory sinus arrhythmia (RSA, an index of parasympathetic activity) decreased and Cortisol did not change. Learners showed greater RSA suppression and less negative affect than nonleamers. This pattern was particularly evident in the preterm group. Overall, preterm infants showed less learning, spent less time looking at the mobile, and had lower Cortisol levels than full‐term infants. Preterm infants also showed greater heart rate responses to contingency and dampened heart rate responses to nonreinforcement compared to full‐term infants. Findings underscore differences in basal and reactivity measures in preterm compared to full‐term infants and suggest that the capacity to regulate parasympathetic activity during a challenge enhances learning in preterm infants.     

Maternal Cocaine Use and Infant Behavior

This study examined the impact of maternal cocaine use and associated risk factors such as polysubstance use, maternal functioning, and caregiving on affect regulation during infancy. Participants were 45 mother‐infant dyads (19 cocaine exposed and 26 control infants) recruited at birth. Observations and maternal reports of infant behavior were obtained at 2 and 7 months of age, along with measures of pre‐ and postnatal substance use, maternal functioning, and caregiving stability. Maternal cocaine use accounted for significant variance in infant positive affect at 2 months. Other substance use and gestational age predicted infant distress to novelty and arousal during developmental assessments. At 7 months, the impact of prenatal cocaine exposure on infant affect regulation was mediated by postnatal alcohol use and caregiving stability. These findings, if replicated, suggest that 1 pathway to later problem behavior reported among substance‐exposed children may be through early regulatory problems and the quality of postnatal caregiving.     

Neurobehavioral Consequences of Prenatal Exposure to Smoking at 6 to 8 Months of Age

Between 400,000 and 800,000 infants are born in the United States each year to women who smoked cigarettes during their pregnancy. Whereas the physical health consequences to infants of prenatal exposure to smoking are well established, the early neurobehavioral consequences are less well understood. This study investigated the neurobehavioral consequences of prenatal exposure to smoking using an epidemiologically derived sample of 454 infants who were drawn from a larger sample of 1,292 infants whose families were recruited at birth. Results indicated that, on average, infants who were exposed to higher levels of prenatal smoking exhibited less positive affect and greater irritability. Moreover, among male infants, elevated levels of prenatal exposure to smoking were associated with lower levels of approach, gross motor movement, reactivity, and attention. There was no evidence that the effects of prenatal exposure to smoking on infant neurobehavioral functioning were mediated by physical growth parameters (infant weight and head circumference) that are also known to be affected by prenatal exposure to smoking.     

Lability of prenatal stress during the COVID-19 pandemic links to negative affect in infancy

The association between prenatal stress and children's socioemotional development is well established. The COVID-19 pandemic has been a particularly stressful period, which may impact the gestational environment. However, most studies to-date have examined prenatal stress at a single time point, potentially masking the natural variation in stress that occurs over time, especially during a time as uncertain as the pandemic. This study leveraged dense ecological momentary assessments from a prenatal randomized control trial to examine patterns of prenatal stress over a 14-week period (up to four assessments/day) in a U.S. sample of 72 mothers and infants. We first examined whether varied features of stress exposure (lability, mean, and baseline stress) differed depending on whether mothers reported on their stress before or during the pandemic. We next examined which features of stress were associated with 3-month-old infants' negative affect. We did not find differences in stress patterns before and during the pandemic. However, greater stress lability, accounting for baseline and mean stress, was associated with higher infant negative affect. These findings suggest that pathways from prenatal stress exposure to infant socioemotional development are complex, and close attention to stress patterns over time will be important for explicating these pathways.     

Physiological Reactivity to Infant Crying and Observed Maternal Sensitivity

Relations between maternal sensitivity and physiological reactivity to infant crying were examined using measures of heart rate (HR) and respiratory sinus arrhythmia (RSA) in 49 mothers of second‐born infants. Using the Ainsworth Sensitivity Scale, an independent assessment of maternal sensitivity was made during maternal free play and bathing of their infants. Physiological reactivity was measured while mothers listened to three blocks of infant cry sounds in a standard cry paradigm. Mothers scoring high on sensitivity were compared to less sensitive mothers on both their physiological reactivity to the presented crying sounds and their physiological mean‐level differences. Significant interaction effects were found for both HR and RSA. Highly sensitive mothers showed a larger increase in HR and stronger RSA withdrawal in response to the first block of cry sounds compared to less sensitive mothers. Main effects showed that highly sensitive mothers had lower mean overall HR, and higher mean RSA levels across all three blocks of crying sounds compared to less sensitive mothers. RSA withdrawal and accompanying HR increases are discussed from a polyvagal perspective as indicative of a better capability in responding to infant signals of negative affect.     

The Regulation of Infant Negative Emotions: The Role of Maternal Sensitivity and Infant‐Directed Speech Prosody

This study explored the role of maternal sensitivity and infant‐directed speech (IDS) prosody in infants’ expression and regulation of negative emotion. Seventy mothers and their 3‐month‐old infants were observed during the Still‐Face Paradigm (SFP). Maternal sensitivity and IDS prosody were assessed at baseline and infant negative affect in the baseline, still‐face, and reunion episodes. Results showed that prototypical IDS prosody characterized by wider fundamental frequency (F0) variability was related to decreases in infant's negative affect, but only if accompanied by maternal sensitivity. Infants of sensitive mothers who spoke with more prototypical IDS prosody showed better abilities to regulate negative affect during the SFP. When prototypical IDS prosody was accompanied by low maternal sensitivity, infants showed lower regulation of negative emotions. In conclusion, infant negative affect regulation in a dyadic setting is facilitated by an optimal combination of both more prototypical maternal IDS prosody and maternal sensitive responsiveness. Implications for the study of mother–infant interaction are discussed.     

Maternal neural reactivity during pregnancy predicts infant temperament

Maternal biological systems impact infant temperament as early as the prenatal period, though the mechanisms of this association are unknown. Using a prospective, longitudinal design, we found that maternal (N = 89) amplitudes of the late positive potential (LPP) in response to negative stimuli during the second, but not the third, trimester of pregnancy predicted observed and physiological indices of temperamental reactivity in infants at age 4 months. Maternal LPP was positively associated with observed infant fear and negatively associated with frontal EEG asymmetry and cortisol reactivity in infants at age 4 months. Results identify a putative mechanism, early in pregnancy, for the intergenerational transmission of emotional reactivity from mother to infant.     

Very Preterm and Full‐Term Infants’ Response to Socio‐Emotional Stress: The Role of Postnatal Maternal Bonding

Very preterm (VPT) infants are at risk for altered socio‐emotional stress regulation, even in the absence of perinatal complications. Moreover, becoming a mother of a VPT infant is a traumatic event, which might affect the establishment of a bonding relationship toward the infant during the postnatal period. The main aim of the present study was to assess the association between maternal postnatal bonding and socio‐emotional stress response in 3‐month‐old VPT infants, compared to full‐term (FT) controls. Thirty‐three VPT and 28 FT infant‐mother dyads underwent the maternal Face‐to‐Face Still‐Face (FFSF) procedure to assess socio‐emotional stress regulation. Maternal postnatal bonding was measured through the Maternal Post‐Natal Attachment Scale (MPAS), which includes three scales: Quality of attachment, Absence of hostility, and Pleasure in interaction. The VPT infants exhibited less self‐directed and other‐directed regulatory behaviors during the Still‐Face episode. Mothers of VPT infants reported lower Quality of attachment compared to FT counterparts. Importantly, higher levels of Quality of attachment were associated with more other‐directed behaviors during the Still‐Face episode in FT dyads, whereas this was not observed in VPT dyads. In conclusion, VPT infants might be exposed to a double‐risk condition for socio‐emotional development, encompassing both difficulties in stress response and the exposure to a less‐than‐optimal maternal bonding.     

Infant Affect During Parent—Infant Interaction at 3 and 6 Months: Differences Between Mothers and Fathers and Influence of Parent History of Depression

Fifty families participated in mother‐infant and father‐infant still‐face interaction at infant ages 3 and 6 months as part of a study of affect in early parent‐infant relationships. Infants' positive and negative affect and parents' positive affect and physical play were coded from videotapes. Consistent with previous research, during the normal condition, mothers displayed more positive affect than did fathers, and fathers were more likely than mothers to display physical play. Infants were more positive with mothers than with fathers. Parents' positive affect but not parent gender predicted infants' positive affect at 6 months. During the still‐face condition, infants of parents with a lifetime history of depression were more likely to display negative affect and less likely to display positive affect than infants with no such parent history. Infants' affect was unrelated to parents' current level of depressive symptoms, which indicates the value of considering family history of psychopathology when examining individual differences in infants' affect.     

The effect of the still‐face paradigm on infant behavior: A cross‐cultural comparison between mothers and fathers

Most still‐face paradigm (SFP) studies have been done in Western families with infant–mother dyads. The present study investigated the SFP pattern in 123 Dutch and 63 Chinese 4‐month‐old infants with mothers and fathers. The classic SFP effect was found for positive affect and gaze in both countries. For negative affect, Chinese infants showed a different SFP pattern than Dutch infants. With fathers, infants displayed a less pronounced SFP pattern for positive affect and an increase from the still face to the reunion for negative affect. Only a minority of infants showed the expected SFP pattern across episodes. Our findings support that infant emotion expression is influenced by parent gender and cultural context. An interesting avenue for further study is the exploration of the origins of within‐ and between‐gender and culture differences in affective communication between parents and infants.     

Prenatal Reflective Functioning and Accumulated Risk as Predictors of Maternal Interactive Behavior During Free Play,the Still‐Face Paradigm,and Two Teaching Tasks

This study examined whether prenatal reflective functioning (RF) was related to mothers’ interactive style across contexts with their 6‐month‐old infants (M age = 6.02 months, SD = 0.41, 54% boys), and to what extent quality of prenatal RF could account for the influence of accumulated risk on maternal interactive behavior. Accumulated risk was defined as the sum‐score of a selection of risk factors that have been associated with suboptimal infant development. Mother–infant dyads (N = 133) were observed during free play, two teaching tasks, and the Still‐Face Paradigm (SFP). Better prenatal RF was associated with more positive maternal behavior in all settings and less negative behavior during teaching and SFP reengagement. Accumulated risk and prenatal RF predicted shared variance in maternal interactive behavior (with unique predictive effects observed only for RF on sensitivity during teaching and SFP play, and for accumulated risk on sensitivity and positive engagement during SFP play, and internalizing‐helplessness during SFP reengagement). Accumulated risk had an indirect effect on maternal sensitivity during teaching and SFP play through prenatal RF. These findings suggest not only that RF may be targeted prenatally to improve mother–infant interactions, but also that enhancing RF skills may ameliorate some of the negative consequences from more stable perinatal risk factors that influence parent–child interactions.     

Infants’ response to a mobile phone modified still‐face paradigm: Links to maternal behaviors and beliefs regarding technoference

Interruptions to parent–child interactions due to technology, or “technoference,” have been correlated with a host of negative child developmental outcomes. Yet, the influence of technoference on parent–infant interactions and infant behaviors has received less attention and more experimental work is warranted. For this study, parent–infant dyads (n = 227) completed a modified still‐face paradigm (SFP) using a mobile phone during the still‐face phase. Infant responses were coded for positive and negative affect, object and parent orientation, self‐comforting, and escape behaviors during the task. Results showed a robust still‐face effect, with infants displaying increased negative affect, decreased positive affect, increased self‐comforting, object orientation, and escape behaviors during the “still‐face” or phone distracted phase of the paradigm and frequently failing to return to baseline during the reunion phase. Older infants (older than 9 months) likewise demonstrated higher levels of negative affect across all three phases of the paradigm relative to younger infants (less than 9 months). Parent reports of technoference behavior were related to increased object orientation for younger infants. Parental technoference behaviors were also linked to more escape behaviors for younger infants and decreased object orientation in older infants during the still‐face portion of the SFP. Higher levels of technoference also appear to attenuate the negative emotional response of infants during still face. Results are discussed in relation to infants’ increasing exposure to digital technology in the context of early relationships.     

Infants’ Biological Sensitivity to the Effects of Maternal Social Support: Evidence Among Mexican American Families

The identification of infants who are most susceptible to both negative and positive social environments is critical for understanding early behavioral development. This study longitudinally assessed the interactive effects of infant vagal tone (respiratory sinus arrhythmia; RSA) and maternal social support on behavioral problems and competence among 322 low‐income Mexican American mother–infant dyads (infants: 54.1% female) and explored sex differences. Infant RSA was calculated from resting HR data at 6 weeks of age. Mothers reported on general social support, partner support, and family support at 6 months, and infant behavioral problems and competence at 1 year. Two‐way interactions (RSA × support source) were evaluated to predict behavioral problems and competence, adjusting for covariates. Results indicated higher competence among infants with lower RSA whose mothers reported higher general support or higher partner support. Interactive effects on behavior problems of RSA with maternal partner or family support were only found for female infants: Girls with higher RSA showed more behavior problems when mothers reported low support, but fewer problem levels in the context of high support. Our results suggest that infant RSA is an important moderator of the effects of the early social environment on early development.     

Infant Behavior and Competence Following Prenatal Exposure to a Natural Disaster: The QF2011 Queensland Flood Study

This study utilized a natural disaster to investigate the effects of prenatal maternal stress (PNMS) arising from exposure to a severe flood on maternally reported infant social–emotional and behavioral outcomes at 16 months, along with potential moderation by infant sex and gestational timing of flood exposure. Women pregnant during the Queensland floods in January 2011 completed measures of flood‐related objective hardship and posttraumatic stress (PTS). At 16 months postpartum, mothers completed measures describing depressive symptoms and infant social–emotional and behavioral problems (n = 123) and competence (n = 125). Greater maternal PTS symptoms were associated with reduced infant competence. A sex difference in infant behavioral problems emerged at higher levels of maternal objective hardship and PTS; boys had significantly more behavioral problems than girls. Additionally, greater PTS was associated with more behavioral problems in boys; however, this effect was attenuated by adjustment for maternal depressive symptoms. No main effects or interactions with gestational timing were found. Findings highlight specificity in the relationships between PNMS components and infant outcomes and demonstrate that the effects of PNMS exposure on behavior may be evident as early as infancy. Implications for the support of families exposed to a natural disaster during pregnancy are discussed.     

The Impact of Maternal Characteristics and Sensitivity on the Concordance Between Maternal Reports and Laboratory Observations of Infant Negative Emotionality

The moderating role of maternal characteristics and maternal sensitivity on the concordance between maternal reports and laboratory observations of negative emotionality was examined. Participants were 90 primiparous mothers and their infants. Mothers completed questionnaires about remembered care from their own parents and their depressive symptoms prenatally, infant temperament (distress to novelty and distress to limitations), and depressive symptoms postnatally. Mothers and infants participated in a laboratory assessment of infant temperament (distress to novelty and limitations) and maternal sensitivity at 6 months postpartum. Several factors that moderate the degree of concordance between maternal reports and behavioral observations were identified, as predicted. Novelty concordance was higher when mothers reported having their emotional needs met in childhood and low prenatal depressive symptoms. Limitations concordance was higher when mothers were less sensitive during the observational tasks. Methodological and theoretical implications are discussed.     

The effect of the COVID-19 pandemic on infant development and maternal mental health in the first 2 years of life

We investigated how exogenous variation in exposure to the COVID-19 pandemic during the first year of life is related to infant development, maternal mental health, and perceived stress. Ninety-three socioeconomically diverse pregnant women were recruited before the pandemic to participate in a longitudinal study. Infants ranged in age at the beginning of lockdown (0–9.5 months old), thus experiencing different durations of pandemic exposure across the first year of life. The duration of pandemic exposure was not associated with family demographic characteristics, suggesting it captured exogenous variability. We tested associations between this exogenous variation in pandemic exposure and child and family outcomes. We also examined whether mother-reported disruptive life events were correlated with child and family outcomes. We found no association between duration of pandemic exposure in the first year of life and infant socioemotional problems, infant language development, or maternal mental health and perceived stress symptoms, at 12 or 24 months. However, we found that self-reported exposure to pandemic-related disruptive life events predicted greater maternal depression, anxiety, and perceived stress at 12 months, and greater depression and anxiety at 24 months. Socioeconomic status did not moderate these associations. These findings suggest cautious optimism for infants raised during this period.