Some new group divisible designs

The paper lists four new group divisible designs which are obtained by trial and error. These designs are believed to be new, since they are not listed in Clatworthy (1973), Freeman (1976) or John and Turner (1977).     

Designs for cropping systems research

The present article establishes equivalence between extended group divisible (EGD) designs and designs for crop sequence experiments. This equivalence has encouraged the agricultural experimenters to use EGD designs for their experimentation. Some real life applications of EGD designs have been given. It has also been shown that several existing association schemes are special cases of EGD association scheme. Some methods of construction of EGD designs are also given. A catalogue of EGD designs obtainable through methods of construction along with efficiency factors of various factorial effects is also presented. In some crop sequence experiments that are conducted to develop suitable integrated nutrient supply system of a crop sequence, the treatments do not comprise of a complete factorial structure. The experimenter is interested in estimating the residual and direct effect of the treatments along with their cumulative effects. For such experimental settings block designs with two sets of treatments applied in succession are the appropriate designs. The correspondence established between row–column designs and block designs for two stage experiments by Parsad et al. [2003. Structurally incomplete row–column designs. Comm. Statist. Theory Methods 32(1), 239–261] has been exploited in obtaining designs for such experimental situations. Some open problems related to designing of crop sequence experiments are also given.     

Some constructions for PBIBDs

New families of group divisible designs have recently been constructed by Bush, by Kageyama and Tanaka, and by Bhagwandas and Parihar. Their constructions are generalised here.     

Approximate and exact optimal designs for paired comparisons of partial profiles when there are two groups of factors

For paired comparison experiments involving pairs of multifactor options differing in a specified number of factors the problem of finding optimal designs is considered, when only main effects are to be estimated. It is presumed that the set of factors can be partitioned into two groups such that the number of levels is constant within each group. The optimal designs for this frequently encountered case are also optimal for the corresponding choice experiments under the hypothesis that the parameters in the multinomial logit model are equal to zero.     

Optimum covariate designs in partially balanced incomplete block (PBIB) design set-ups

The use of covariates in block designs is necessary when the covariates cannot be controlled like the blocking factor in the experiment. In this paper, we consider the situation where there is some flexibility for selection in the values of the covariates. The choice of values of the covariates for a given block design attaining minimum variance for estimation of each of the parameters has attracted attention in recent times. Optimum covariate designs in simple set-ups such as completely randomised design (CRD), randomised block design (RBD) and some series of balanced incomplete block design (BIBD) have already been considered. In this paper, optimum covariate designs have been considered for the more complex set-ups of different partially balanced incomplete block (PBIB) designs, which are popular among practitioners. The optimum covariate designs depend much on the methods of construction of the basic PBIB designs. Different combinatorial arrangements and tools such as orthogonal arrays, Hadamard matrices and different kinds of products of matrices viz. Khatri–Rao product, Kronecker product have been conveniently used to construct optimum covariate designs with as many covariates as possible.     

Lower Bounds for the Efficiency of Designs with Respect to the D-Criterion when the Observations are Correlated

In the general linear model consider the experimental design problem for the Gauß-Markov estimator or least squares estimator when the observations are correlated. We prove new formulas for the efficiency of an exact design with respect to the D-criterion. For models with intercept term, for example, these formulas are useful to derive better lower bounds for the efficiency than the bounds recently given for an arbitrary linear model. These bounds are applied in examples to symmetrical regular circulants as covariance matrices. A byproduct of the investigations is some insight as to what kinds of designs might retain their optimality or high efficiency (for the uncorrelated homoscedastic case) under correlated observations.     

Orthogonal Latin hypercube designs from generalized orthogonal designs

Latin hypercube designs is a class of experimental designs that is important when computer simulations are needed to study a physical process. In this paper, we proposed some general criteria for evaluating Latin hypercube designs through their alias matrices. Moreover, a general method is proposed for constructing orthogonal Latin hypercube designs. In particular, links between orthogonal designs (ODs), generalized orthogonal designs (GODs) and orthogonal Latin hypercube designs are established. The generated Latin hypercube designs have some favorable properties such as uniformity, orthogonality of the first and some second order terms, and optimality under the defined criteria.     

A note on the connection between uniformity and generalized minimum aberration

Discrete discrepancy has been utilized as a uniformity measure for comparing and evaluating factorial designs. In this paper, for asymmetrical factorials, we give some linkages between uniformity measured by the discrete discrepancy and other criteria, such as generalized minimum aberration (Xu and Wu, 2001) and minimum projection variance (Ai and Zhang, 2004). These close linkages show a significant justification for the discrete discrepancy used to measure uniformity of factorial designs, and provide an additional rationale for using uniform designs. This research was partially supported by the NNSF of China (No. 10441001), the Key Project of Chinese Ministry of Education (No. 105119) and the Project-sponsored by SRF for ROCS (SEM) (No. [2004]176).     

Optimal saturated block designs when observations are correlated

A- and MV-optimal block designs are identified in the class of minimally connected designs when the observations within blocks are spatially correlated. All connected designs are shown to be D-equal regardless of the correlation structure, and a sufficient condition for E-optimality is presented. Earlier results for the uncorrelated case are strengthened.     

Optimality and bias of some interpolation and extrapolation designs

We consider interpolation and extrapolation designs with controlled bias. A consistent estimate of an upper bound of the bias is presented. The estimate of some extrapolated value is obtained in a two-stage procedure. The first one provides an estimate of some interpolated value. The second one uses a Taylor expansion around this point. This procedure yields a new type of designs. We discuss their optimality properties with respect to the variance and the bias.     

Construction of some classes of balanced cross-over designs from terraces

5 and 6 have recently introduced power-sequence terraces. In this paper we have used these terraces for the construction of some new families of balanced cross-over designs of first and second order which are variance-balanced. We have also used them for the construction of some new families of balanced ternary cross-over designs.     

Addition of runs to a two-level supersaturated design

The purpose of this article is to introduce a new class of extended E(s²)-optimal two level supersaturated designs obtained by adding runs to an existing E(s²)-optimal two level supersaturated design. The extended design is a union of two optimal SSDs belonging to different classes. New lower bound to E(s²) has been obtained for the extended supersaturated designs. Some examples and a small catalogue of E(s²)-optimal SSDs are also included.     

On representing maximin efficient designs by Taylor series

This paper considers exponential and rational regression models that are nonlinear in some parameters. Recently, locally D-optimal designs for such models were investigated in [Melas, V. B., 2005. On the functional approach to optimal designs for nonlinear models. J. Statist. Plann. Inference 132, 93–116] based upon a functional approach. In this article a similar method is applied to construct maximin efficient D-optimal designs. This approach allows one to represent the support points of the designs by Taylor series, which gives us the opportunity to construct the designs by hand using tables of the coefficients of the series. Such tables are provided here for models with two nonlinear parameters. Furthermore, the recurrent formulas for constructing the tables for arbitrary numbers of parameters are introduced.     

Optimal crossover designs when carryover effects are proportional to direct effects

Crossover designs are used for a variety of different applications. While these designs have a number of attractive features, they also induce a number of special problems and concerns. One of these is the possible presence of carryover effects. Even with the use of washout periods, which are for many applications widely accepted as an indispensable component, the effect of a treatment from a previous period may not be completely eliminated. A model that has recently received renewed attention in the literature is the model in which first-order carryover effects are assumed to be proportional to direct treatment effects. Under this model, assuming that the constant of proportionality is known, we identify optimal and efficient designs for the direct effects for different values of the constant of proportionality. We also consider the implication of these results for the case that the constant of proportionality is not known.     

Families of regular designs based on geometries

Recently Bush and Ostrom (1979) settled most of the open questions with respect to inequivalent solutions of a class of semiregular (SR) designs which can be constructed from nets. This paper is a study of the same nature for two families of regular (R) designs derived from finite projective planes. One family presents no problems, but the other which is a ‘double’ family with two parameters is much more difficult. In fact it is here solved only for designs based on planes of orders 3, 4, 5 and 8. Certain general methods exist which are indicated, but we were unable to resolve even the case 7 using this technique.Basically we show the existence of either inequivalent solutions or show there is but one solution settling a number of open cases. In particular for the case λ₁ = 2, λ₂ = 1 we give new solutions to a number of D(2) designs or group divisible designs with two associate classes which have no repeated blocks in contrast with the published solutions which have this undesirable property for a number of applications.     

Efficient experimental designs for sigmoidal growth models

For the Weibull- and Richards-regression model robust designs are determined by maximizing a minimum of D  - or _D1$D_1$-efficiencies, taken over a certain range of the non-linear parameters. It is demonstrated that the derived designs yield a satisfactory solution of the optimal design problem for this type of model in the sense that these designs are efficient and robust with respect to misspecification of the unknown parameters. Moreover, the designs can also be used for testing the postulated form of the regression model against a simplified sub-model.     

Invariance of generalized wordlength patterns

The generalized wordlength pattern (GWLP) introduced by Xu and Wu [2001. Generalized minimum aberration for asymmetrical fractional factorial designs. Ann. Statist. 29, 1066–1077] for an arbitrary fractional factorial design allows one to extend the use of the minimum aberration criterion to such designs. Ai and Zhang [2004. Projection justification of generalized minimum aberration for asymmetrical fractional factorial designs. Metrika 60, 279–285] defined the J$J$-characteristics of a design and showed that they uniquely determine the design. While both the GWLP and the J$J$-characteristics require indexing the levels of each factor by a cyclic group, we see that the definitions carry over with appropriate changes if instead one uses an arbitrary abelian group. This means that the original definitions rest on an arbitrary choice of group structure. We show that the GWLP of a design is independent of this choice, but that the J$J$-characteristics are not. We briefly discuss some implications of these results.     

Optimal discrimination designs for exponential regression models

We investigate optimal designs for discriminating between exponential regression models of different complexity, which are widely used in the biological sciences; see, e.g., Landaw [1995. Robust sampling designs for compartmental models under large prior eigenvalue uncertainties. Math. Comput. Biomed. Appl. 181–187] or Gibaldi and Perrier [1982. Pharmacokinetics. Marcel Dekker, New York]. We discuss different approaches for the construction of appropriate optimality criteria, and find sharper upper bounds on the number of support points of locally optimal discrimination designs than those given by Caratheodory's Theorem. These results greatly facilitate the numerical construction of optimal designs. Various examples of optimal designs are then presented and compared to different other designs. Moreover, to protect the experiment against misspecifications of the nonlinear model parameters, we adapt the design criteria such that the resulting designs are robust with respect to such misspecifications and, again, provide several examples, which demonstrate the advantages of our approach.     

Some sufficient conditions for establishing (M,S)-optimality

Two sufficient conditions are given for an incomplete block design to be (M,S- optimal. For binary designs the conditions are (i) that the elements in each row, excluding the diagonal element, of the association matrix differ by at most one, and (ii) that the off-diagonal elements of the block characteristic matrix differ by at most one. It is also shown how the conditions can be utilized for nonbinary designs and that for blocks of size two the sufficient condition in terms of the association matrix can be attained.     

Exact Designs Minimising the Integrated Variance in Quadratic Regression

Exact designs are given which minimise the average variance of a quadratic regression polynomial fitted by the method of least squares.