A Modification of a Percentile Estimation Procedure Based on Generalized Polya Urns

Adaptive designs find an important application in the estimation of unknown percentiles for an underlying dose-response curve. A nonparametric adaptive design was suggested by Mugno et al. (2004 Mugno, R.A., Zhus, W., Rosenberger, W.F. (2004). Adaptive urn designs for estimating several percentiles of a dose-response curve. Statist. Med. 23(13):2137–2150.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) to simultaneously estimate multiple percentiles of an unknown dose-response curve via generalized Polya urns. In this article, we examine the properties of the design proposed by Mugno et al. (2004 Mugno, R.A., Zhus, W., Rosenberger, W.F. (2004). Adaptive urn designs for estimating several percentiles of a dose-response curve. Statist. Med. 23(13):2137–2150.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) when delays in observing responses are encountered. Using simulations, we evaluate a modification of the design under varying group sizes. Our results demonstrate unbiased estimation with minimal loss in efficiency when compared to the original compound urn design.     

Credibility premium for rate-making systems

Credibility formula has been developed in many fields of actuarial sciences. Based upon Payandeh (2010 Payandeh, A.T. (2010). A new approach to the credibility formula. Insur.: Math. Econ. 46(2):334–338.[Crossref], [Web of Science ®] , [Google Scholar]), this article extends concept of credibility formula to relatively premium of a given rate-making system. More precisely, it calculates Payandeh’s (2010 Payandeh, A.T. (2010). A new approach to the credibility formula. Insur.: Math. Econ. 46(2):334–338.[Crossref], [Web of Science ®] , [Google Scholar]) credibility factor for zero-inflated Poisson gamma distributions with respect to several loss functions. A comparison study has been given.     

Bayesian Estimation for Linear Functions of Poisson Rates

The probability matching prior for linear functions of Poisson parameters is derived. A comparison is made between the confidence intervals obtained by Stamey and Hamilton (2006 Stamey, J., Hamilton, C. (2006). A note on confidence intervals for a linear function of Poisson rates. Commun. Statist. Simul. &; Computat. 35(4):849–856.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]), and the intervals derived by us when using the Jeffreys’ and probability matching priors. The intervals obtained from the Jeffreys’ prior are in some cases fiducial intervals (Krishnamoorthy and Lee, 2010 Krishnamoorthy, K., Lee, M. (2010). Inference for functions of parameters in discrete distributions based on fiducial approach: Binomial and Poisson cases. J. Statist. Plann. Infere. 140(5):1182–1192.[Crossref], [Web of Science ®] , [Google Scholar]). A weighted Monte Carlo method is used for the probability matching prior. The power and size of the test, using Bayesian methods, is compared to tests used by Krishnamoorthy and Thomson (2004 Krishnamoorthy, K., Thomson, J. (2004). A more powerful test for comparing two Poisson means. J. Statist. Plann. Infere. 119(1):23–35.[Crossref], [Web of Science ®] , [Google Scholar]). The Jeffreys’, probability matching and two other priors are used.     

Matrix mean squared error comparisons of some biased estimators with two biasing parameters

To deal with multicollinearity problem, the biased estimators with two biasing parameters have recently attracted much research interest. The aim of this article is to compare one of the last proposals given by Yang and Chang (2010 Yang, H., and X. Chang. 2010. A new two-parameter estimator in linear regression. Communications in Statistics: Theory and Methods 39 (6):923–34.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) with Liu-type estimator (Liu 2003 Liu, K. 2003. Using Liu-type estimator to combat collinearity. Communications in Statistics: Theory and Methods 32 (5):1009–20.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and k ? d class estimator (Sakallioglu and Kaciranlar 2008 Sakallioglu, S., and S. Kaciranlar. 2008. A new biased estimator based on ridge estimation. Statistical Papers 49:669–89.[Crossref], [Web of Science ®] , [Google Scholar]) under the matrix mean squared error criterion. As well as giving these comparisons theoretically, we support the results with the extended simulation studies and real data example, which show the advantages of the proposal given by Yang and Chang (2010 Yang, H., and X. Chang. 2010. A new two-parameter estimator in linear regression. Communications in Statistics: Theory and Methods 39 (6):923–34.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) over the other proposals with increasing multicollinearity level.     

Using the Inverse Maximum Ratio-Λ as a Technique to Quantify Surface Uniformity

Techniques used in variability assessment are subsequently used to draw conclusions regarding the “spread”/uniformity of data curves. Due to the limitations of these techniques, they are not adequate for circumstances where data manifest with multiple peaks. Examples of these manifestations (in three-dimensional space) include under-foot pressure distributions recorded for different types of footwear (Becerro-de-Bengoa-Vallejo et al., 2014 Biau, D.J. (2011). In brief: Standard deviation and standard error. Clinical Orthopaedics and Related Research 469(9):2661–2664.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Cibulka et al., 1994 Cibulka, M.T., Sinacore, D.R., Mueller, M.J. (1994). Shin splints and forefoot contact running: A case report. Journal of Orthopaedic &; Sports Physical Therapy 20(2):98–102.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Davies et al., 2003 Davies, M.B., Betts, R.P., Scott, I.R. (2003). Optical plantar pressure analysis following internal fixation for displaced intra-articular os calcis fractures. Foot &; Ankle International 24(11):851–856.[PubMed], [Web of Science ®] , [Google Scholar]), surface textures and interfaces designed to impact friction, and and and molecular surface structures such as viral epitopes (Torras and Garcia-Valls, 2004 Torras, C., Garcia-Valls, R. (2004). Quantification of membrane morphology by interpretation of scanning electron microscopy images. Journal of Membrane Science 233(1–2):119–127.[Crossref], [Web of Science ®] , [Google Scholar]; Pacejka, 1997; Fustaffson, 1997). This article proposes a technique for generating a single variable – Λ that will quantify the uniformity of such surfaces. We define and validate this technique using several mathematical and graphical models.     

On the Properties of the SAVE Directions

In quadratic discriminant analysis, the use of SAVE (Cook and Weisberg, 1991 Cook, R.D., Weisberg, S. (1991). Discussion of Li (1991). J. Amer. Statist. Assoc. 86:328–32.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]; Pardoe et al., 2007 Pardoe, I., Yin, X., Cook, R. (2007). Graphical tools for quadratic discriminant analysis. Technometrics 49:172–183.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) is often recommended for dimension-reduction purposes. However, the associated directions tend to over-emphasize the differences of the groups in dispersion, ignoring at the same time those in location. This behavior makes often the plots of the corresponding canonical coordinates difficult to interpret. In this article, the properties of SAVE are investigated and related to those of the SIR and SIRII components. Applications with real data are presented. Comparisons with previous work in this area are also discussed.     

Multivariate Bayesian U-type asymmetric designs for non parametric response surface prediction under correlated errors

The objective of this paper is to study U-type designs for Bayesian non parametric response surface prediction under correlated errors. The asymptotic Bayes criterion is developed in terms of the asymptotic approach of Mitchell et al. (1994 Mitchell, T., Sacks, J., Ylvisaker, D. (1994). Asymptotic Bayes criteria for nonparametric response surface design. Ann. Stat. 22:634–651.[Crossref], [Web of Science ®] , [Google Scholar]) for a more general covariance kernel proposed by Chatterjee and Qin (2011 Chatterjee, K., Qin, H. (2011). Generalized discrete discrepancy and its applications in experimental designs. J. Stat. Plann. Inference 141:951–960.[Crossref], [Web of Science ®] , [Google Scholar]). A relationship between the asymptotic Bayes criterion and other criteria, such as orthogonality and aberration, is then developed. A lower bound for the criterion is also obtained, and numerical results show that this lower bound is tight. The established results generalize those of Yue et al. (2011 Yue, R.X., Qin, H., Chatterjee, K. (2011). Optimal U-type design for Bayesian nonparametric multiresponse prediction. J. Stat. Plann. Inference 141:2472–2479.[Crossref], [Web of Science ®] , [Google Scholar]) from symmetrical case to asymmetrical U-type designs.     

An Approximation Model of the Collective Risk Model with INAR(1) Claim Process

Cossette et al. (2010 Cossette, H., Marceau, E., Maume-Deschamps, V. (2010). Discerte-time risk models based on time series for count random variables. ASTIN Bull. 40:123–150.[Crossref], [Web of Science ®] , [Google Scholar], 2011 Cossette, H., Marceau, E., Toureille, F. (2011). risk models based on time series for count random variables. Insur. Math. Econ. 48:19–28.[Crossref], [Web of Science ®] , [Google Scholar]) gave a novel collective risk model where the total numbers of claims satisfy the first-order integer-valued autoregressive process. For a risk model, it is interesting to investigate the upper bound of ruin probability. However, the loss increments of the above model are dependent; it is difficult to derive the upper bound of ruin probability. In this article, we propose an approximation model with stationary independent increments. The upper bound of ruin probability and the adjustment coefficient are derived. The approximation model is illustrated via four simulated examples. Results show that the gap of the approximation model and dependent model can be ignored by adjusting values of parameters.     

On extreme order statistics from heterogeneous beta distributions with applications

This paper treats the problem of stochastic comparisons for the extreme order statistics arising from heterogeneous beta distributions. Some sufficient conditions involved in majorization-type partial orders are provided for comparing the extreme order statistics in the sense of various magnitude orderings including the likelihood ratio order, the reversed hazard rate order, the usual stochastic order, and the usual multivariate stochastic order. The results established here strengthen and extend those including Kochar and Xu (2007 Kochar, S.C., Xu, M. (2007). Stochastic comparisons of parallel systems when components have proportional hazard rates. Probab. Eng. Inf. Sci. 21:597–609.[Crossref], [Web of Science ®] , [Google Scholar]), Mao and Hu (2010 Mao, T., Hu, T. (2010). Equivalent characterizations on orderings of order statistics and sample ranges. Probab. Eng. Inf. Sci. 24:245–262.[Crossref], [Web of Science ®] , [Google Scholar]), Balakrishnan et al. (2014 Balakrishnan, N., Barmalzan, G., Haidari, A. (2014). On usual multivariate stochastic ordering of order statistics from heterogeneous beta variables. J. Multivariate Anal. 127:147–150.[Crossref], [Web of Science ®] , [Google Scholar]), and Torrado (2015 Torrado, N. (2015). On magnitude orderings between smallest order statistics from heterogeneous beta distributions. J. Math. Anal. Appl. 426:824–838.[Crossref], [Web of Science ®] , [Google Scholar]). A real application in system assembly and some numerical examples are also presented to illustrate the theoretical results.     

An efficient use of moment's ratios of scrambling variables in a randomized response technique

This paper aimed at providing an efficient new unbiased estimator for estimating the proportion of a potentially sensitive attribute in survey sampling. The suggested randomization device makes use of the means, variances of scrambling variables, and the two scalars lie between “zero” and “one.” Thus, the same amount of information has been used at the estimation stage. The variance formula of the suggested estimator has been obtained. We have compared the proposed unbiased estimator with that of Kuk (1990 Kuk, A.Y.C. (1990). Asking sensitive questions inderectely. Biometrika 77:436–438.[Crossref], [Web of Science ®] , [Google Scholar]) and Franklin (1989 Franklin, L.A. (1989). A comparision of estimators for randomized response sampling with continuous distribution s from a dichotomous population. Commun. Stat. Theor. Methods 18:489–505.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]), and Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:3377–3380.[Crossref], [Web of Science ®] , [Google Scholar]) estimators. Relevant conditions are obtained in which the proposed estimator is more efficient than Kuk (1990 Kuk, A.Y.C. (1990). Asking sensitive questions inderectely. Biometrika 77:436–438.[Crossref], [Web of Science ®] , [Google Scholar]) and Franklin (1989 Franklin, L.A. (1989). A comparision of estimators for randomized response sampling with continuous distribution s from a dichotomous population. Commun. Stat. Theor. Methods 18:489–505.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:3377–3380.[Crossref], [Web of Science ®] , [Google Scholar]) estimators. The optimum estimator (OE) in the proposed class of estimators has been identified which finally depends on moments ratios of the scrambling variables. The variance of the optimum estimator has been obtained and compared with that of the Kuk (1990 Kuk, A.Y.C. (1990). Asking sensitive questions inderectely. Biometrika 77:436–438.[Crossref], [Web of Science ®] , [Google Scholar]) and Franklin (1989 Franklin, L.A. (1989). A comparision of estimators for randomized response sampling with continuous distribution s from a dichotomous population. Commun. Stat. Theor. Methods 18:489–505.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) estimator and Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:3377–3380.[Crossref], [Web of Science ®] , [Google Scholar]) estimator. It is interesting to mention that the “optimum estimator” of the class of estimators due to Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:3377–3380.[Crossref], [Web of Science ®] , [Google Scholar]) depends on the parameter π under investigation which limits the use of Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:3377–3380.[Crossref], [Web of Science ®] , [Google Scholar]) OE in practice while the proposed OE in this paper is free from such a constraint. The proposed OE depends only on the moments ratios of scrambling variables. This is an advantage over the Singh and Chen (2009 Singh, S., Chen, C.C. (2009). Utilization of higher order moments of scrambling variables in randomized response sampling. J. Stat. Plann. Inference. 139:3377–3380.[Crossref], [Web of Science ®] , [Google Scholar]) estimator. Numerical illustrations are given in the support of the present study when the scrambling variables follow normal distribution. Theoretical and empirical results are very sound and quite illuminating in the favor of the present study.     

Linear transformation models for survival analysis with tumor growth information in cancer screening study

The complication in analyzing tumor data is that the tumors detected in a screening program tend to be slowly progressive tumors, which is the so-called left-truncated sampling that is inherent in screening studies. Under the assumption that all subjects have the same tumor growth function, Ghosh (2008 Ghosh, D. (2008). Proportional hazards regression for cancer studies. Biometrics 64:141–148.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) developed estimation procedures for the Cox proportional hazards model. Shen (2011a Shen, P.-S. (2011a). Proportional hazards regression for cancer screening data. J. Stat. Comput. Simul. 18:367–377.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) demonstrated that Ghosh (2008 Ghosh, D. (2008). Proportional hazards regression for cancer studies. Biometrics 64:141–148.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar])'s approach can be extended to the case when each subject has a specific growth function. In this article, under linear transformation model, we present a general framework to the analysis of data from cancer screening studies. We developed estimation procedures under linear transformation model, which includes Cox's model as a special case. A simulation study is conducted to demonstrate the potential usefulness of the proposed estimators.     

Some extensions of circular balanced and circular strongly balanced repeated measurements designs

Repeated measurement designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this paper the works of Iqbal and Tahir (2009 Iqbal, I., and M. H. Tahir. 2009. Circular strongly balanced repeated measurements designs. Communications in Statistics—Theory and Methods 38:3686–96.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and Iqbal, Tahir, and Ghazali (2010 Iqbal, I., M. H. Tahir, and S. S. A. Ghazali. 2010. Circular first- and second-order balanced repeated measurements designs. Communications in Statistics—Theory and Methods 39:228–40.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) are generalized for the construction of circular-balanced and circular strongly balanced repeated measurements designs through the method of cyclic shifts for three periods.     

Weighted geometric distribution with new characterizations of geometric distribution

In this article, we derive a new generalized geometric distribution through a weight function, which can also be viewed as a discrete analog of weighted exponential distribution introduced by Gupta and Kundu (2009 Gupta, R. D., and D. Kundu. 2009. A new class of weighted exponential distributions. Statistics 43:621–34.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]). We derive some distributional properties like moments, generating functions, hazard function, and infinite divisibility followed by different estimation methods to estimate the parameters. New characterizations of the geometric distribution are presented using the proposed generalized geometric distribution. The superiority of the proposed distribution to other competing models is demonstrated with the help of two real count datasets.     

Quantile-based Chernoff distance for truncated random variables

Several probability distributions such as power-Pareto distribution (see Gilchrist 2000 Gilchrist, W. 2000. Statistical modelling with quantile functions. Boca Raton, FL: Chapman and Hall/CRC.[Crossref] , [Google Scholar] and Hankin and Lee 2006 Hankin, R. K. S., and A. Lee. 2006. A new family of non-negative distributions. Australian and New Zealand Journal of Statistics 48:67–78.[Crossref], [Web of Science ®] , [Google Scholar]), various forms of lambda distributions (see Ramberg and Schmeiser 1974 Ramberg, J. S., and B. W. Schmeiser. 1974. An appropriate method for generating asymmetric random variables. Communications of the ACM 17:78–82.[Crossref], [Web of Science ®] , [Google Scholar] and Freimer et al. 1988 Freimer, M., S. Mudholkar, G. Kollia, and C. T. Lin. 1988. A study of the generalized lambda family. Communications in Statistics - Theory and Methods 17:3547–67.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Govindarajulu distribution (see Nair, Sankaran, and Vineshkumar 2012 Nair, U. N., P. G. Sankaran, and B. Vineshkumar. 2012. The Govindarajulu distribution: some properties and applications. Communications in Statistics—Theory and Methods 41:4391–406.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), etc., do not have manageable distribution functions, though they have tractable quantile functions. Hence, analytical study of the properties of Chernoff distance of two random variables associated with these distributions via traditional distribution function-based tool becomes difficult. To make this simple, in this paper, we introduce quantile-based Chernoff distance for (left or right) truncated random variables and study its various properties. Some useful bounds as well as characterization results are obtained.     

On dynamic weighted survival entropy of order α

Recently, Abbasnejad et al. (2010 Abbasnejad, M., Arghami, N.R., Morgenthaler, S., Mohtashami Borzadaran, G.R. (2010). On the dynamic survival entropy. Stat. Probab. Lett. 80:1962–1971.[Crossref], [Web of Science ®] , [Google Scholar]) proposed a measure of uncertainty based on survival function, called the survival entropy of order α. A dynamic form of the survival entropy of order α is also proposed by them. In this paper, we derive the weighted form of these measures. The properties of the new measures are also discussed.     

A Note on the Frequency Polygon Based on the Weighted Sums of Binned Data

We revisit the generalized midpoint frequency polygons of Scott (1985), and the edge frequency polygons of Jones et al. (1998 Jones, M.C., Samiuddin, M., Al-Harbey, A.H., Maatouk, T. A.H. (1998). The edge frequency polygon. Biometrika 85:235–239.[Crossref], [Web of Science ®] , [Google Scholar]) and Dong and Zheng (2001 Dong, J.P., Zheng, C. (2001). Generalized edge frequency polygon for density estimation. Statist. Probab. Lett. 55:137–145.[Crossref], [Web of Science ®] , [Google Scholar]). Their estimators are linear interpolants of the appropriate values above the bin centers or edges, those values being weighted averages of the heights of r, r ∈ N, neighboring histogram bins. We propose a simple kernel evaluation method to generate weights for binned values. The proposed kernel method can provide near-optimal weights in the sense of minimizing asymptotic mean integrated square error. In addition, we prove that the discrete uniform weights minimize the variance of the generalized frequency polygon under some mild conditions. Analogous results are obtained for the generalized frequency polygon based on linearly prebinned data. Finally, we use two examples and a simulation study to compare the generalized midpoint and edge frequency polygons.     

On the Optimality of Circular Block Designs Under a Mixed Interference Model

Filipiak and Markiewicz (2012 Filipiak, K., Markiewicz, A. (2012). On universal optimality of circular weakly neighbor balanced designs under an interference model. Comm. Stat. Theor Methods 41: 2356–2366.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) proved the universal optimality of circular weakly neighbor balanced designs (CWNBDs) under the interference model with fixed neighbor effects among the class of complete block designs. In two special cases where a CWNBD cannot exist, Filipiak et al. (2012 Filipiak, K., Markiewicz, A., Ró?ański, R. (2012). Maximal determinant over a certain class of matrices and its application to D-optimality of designs. Linear Algebra Appl. 436(4): 874–887.[Crossref], [Web of Science ®] , [Google Scholar]) characterized D-optimal designs. The aim of this paper is to show the universal optimality of CWNBDs and to characterize D-optimal designs under the interference model with random neighbor effects.     

Multiple dependent state repetitive sampling plans based on one-sided process capability indices

In this research, multiple dependent state and repetitive group sampling are used to design a variable sampling plan based on one-sided process capability indices, which consider the quality of the current lot as well as the quality of the preceding lots. The sample size and critical values of the proposed plan are determined by minimizing the average sample number while satisfying the producer's risk and consumer's risk at corresponding quality levels. In addition, comparisons are made with the existing sampling plans [Pearn and Wu (2006a Pearn, W. L., and C. W. Wu. 2006a. Critical acceptance values and sample sizes of a variables sampling plan for very low fraction of defectives. Omega: International Journal of Management Science 34 (1):90–101.[Crossref], [Web of Science ®] , [Google Scholar]), Yen et al. (2015 Yen, C. H., C. H. Chang, and M. Aslam. 2015. Repetitive variable acceptance sampling plan for one-sided specification. Journal of Statistical Computation and Simulation 85 (6):1102–16.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar])] in terms of average sample number and operating characteristic curve. Finally, an example is provided to illustrate the proposed plan.     

Weighting variables in Kohonen competitive learning algorithms

This paper presents a new variable weight method, called the singular value decomposition (SVD) approach, for Kohonen competitive learning (KCL) algorithms based on the concept of Varshavsky et al. [18 R. Varshavsky, A. Gottlieb, M. Linial, and D. Horn, Novel unsupervised feature filtering of bilogical data, Bioinformatics 22 (2006), pp. 507–513.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]]. Integrating the weighted fuzzy c-means (FCM) algorithm with KCL, in this paper, we propose a weighted fuzzy KCL (WFKCL) algorithm. The goal of the proposed WFKCL algorithm is to reduce the clustering error rate when data contain some noise variables. Compared with the k-means, FCM and KCL with existing variable-weight methods, the proposed WFKCL algorithm with the proposed SVD's weight method provides a better clustering performance based on the error rate criterion. Furthermore, the complexity of the proposed SVD's approach is less than Pal et al. [17 S.K. Pal, R.K. De, and J. Basak, Unsupervised feature evaluation: a neuro-fuzzy approach, IEEE. Trans. Neural Netw. 11 (2000), pp. 366–376.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]], Wang et al. [19 X.Z. Wang, Y.D. Wang, and L.J. Wang, Improving fuzzy c-means clustering based on feature-weight learning, Pattern Recognit. Lett. 25 (2004), pp. 1123–1132.[Crossref], [Web of Science ®] , [Google Scholar]] and Hung et al. [9 W. -L. Hung, M. -S. Yang, and D. -H. Chen, Bootstrapping approach to feature-weight selection in fuzzy c-means algorithms with an application in color image segmentation, Pattern Recognit. Lett. 29 (2008), pp. 1317–1325.[Crossref], [Web of Science ®] , [Google Scholar]].     

Sample size estimation for comparing rates of change in K-group repeated count outcomes

Sample size estimation for comparing the rates of change in two-arm repeated measurements has been investigated by many investigators. In contrast, the literature has paid relatively less attention to sample size estimation for studies with multi-arm repeated measurements where the design and data analysis can be more complex than two-arm trials. For continuous outcomes, Jung and Ahn (2004 Jung, S., Ahn, C. (2004). K-sample test and sample size calculation for comparing slopes in data with repeated measurements. Biometrical J. 46(5):554–564.[Crossref], [Web of Science ®] , [Google Scholar]) and Zhang and Ahn (2013 Zhang, S., Ahn, C. (2013). Sample size calculation for comparing time-averaged responses in k-group repeated measurement studies. Comput. Stat. Data Anal. 58:283–291.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) have presented sample size formulas to compare the rates of change and time-averaged responses in multi-arm trials, using the generalized estimating equation (GEE) approach. To our knowledge, there has been no corresponding development for multi-arm trials with count outcomes. We present a sample size formula for comparing the rates of change in multi-arm repeated count outcomes using the GEE approach that accommodates various correlation structures, missing data patterns, and unbalanced designs. We conduct simulation studies to assess the performance of the proposed sample size formula under a wide range of designing configurations. Simulation results suggest that empirical type I error and power are maintained close to their nominal levels. The proposed method is illustrated using an epileptic clinical trial example.