On regressing regression coefficients

This paper considers a regression model in which coefficients obtained from a previous regression are themselves the object of analysis. It is shown that the parameters of interest can be obtained in two ways: pooling across observations and subsamples, or a two-stage process of first estimating the coefficients within each subsample, and then using these coefficients as dependent variables in a second stage regression. The relative properties of these estimators are analyzed, and the conditions under which the two estimators are equivalent are derived.     

Optimal designs in random coefficient cubic regression models

In this article we investigate the problem of ascertaining A- and D-optimal designs in a cubic regression model with random coefficients. Our interest lies in estimation of all the parameters or in only those except the intercept term. Assuming the variance ratios to be known, we tabulate D-optimal designs for various combinations of the variance ratios. A-optimality does not pose any new problem in the random coefficients situation.     

Perfect linear models and perfect parametric functions

General linear models with a common design matrix and with various structures of the variance–covariance matrix are considered. We say that a model is perfect for a linearly estimable parametric function, or the function is perfect in the model, if there exists the best linear unbiased estimator. All perfect models for a given function and all perfect functions in a given model are characterized.     

A Note on the Kuks-Olman Estimator

In the linear regression model the unknown parameter vector θ is supposed to vary in a known ellipsoid. Under this parameter constraint Kuks and Olman derived an estimator by demanding a minimax property. Since sometimes the Kuks-Olman estimator takes values outside of the ellipsoid a modification is proposed in the paper. It is shown that this modified variant is a least squares estimator in the restricted model.     

A Jackknife Method for Estimation of Variance Components

This paper concerns a method of estimation of variance components in a random effect linear model. It is mainly a resampling method and relies on the Jackknife principle. The derived estimators are presented as least squares estimators in an appropriate linear model, and one of them appears as a MINQUE (Minimum Norm Quadratic Unbiased Estimation) estimator. Our resampling method is illustrated by an example given by C. R. Rao [7] and some optimal properties of our estimator are derived for this example. In the last part, this method is used to derive an estimation of variance components in a random effect linear model when one of the components is assumed to be known.     

Optimality of the quasi-score estimator in a mean–variance model with applications to measurement error models

We consider a regression of y$y$ on x$x$ given by a pair of mean and variance functions with a parameter vector θ$\theta$ to be estimated that also appears in the distribution of the regressor variable x$x$. The estimation of θ$\theta$ is based on an extended quasi-score (QS) function. We show that the QS estimator is optimal within a wide class of estimators based on linear-in-y$y$ unbiased estimating functions. Of special interest is the case where the distribution of x$x$ depends only on a subvector α$\alpha$ of θ$\theta$, which may be considered a nuisance parameter. In general, α$\alpha$ must be estimated simultaneously together with the rest of θ$\theta$, but there are cases where α$\alpha$ can be pre-estimated. A major application of this model is the classical measurement error model, where the corrected score (CS) estimator is an alternative to the QS estimator. We derive conditions under which the QS estimator is strictly more efficient than the CS estimator.     

Distribution-free tests for parallelism and concurrence in two-sample regression problem

This paper suggests some distribution-free methods for testing hypothesis of parallelism and concurrence of two linear regressions. We assume that the independent variable x is equally spaced. The proposed procedures are compared with nonparametric competitors and the normal theory t-test.     

Robust prediction and extrapolation designs for misspecified generalized linear regression models

We study minimax robust designs for response prediction and extrapolation in biased linear regression models. We extend previous work of others by considering a nonlinear fitted regression response, by taking a rather general extrapolation space and, most significantly, by dropping all restrictions on the structure of the regressors. Several examples are discussed.     

Variance estimation in the central limit theorem for Markov chains

This article concerns the variance estimation in the central limit theorem for finite recurrent Markov chains. The associated variance is calculated in terms of the transition matrix of the Markov chain. We prove the equivalence of different matrix forms representing this variance. The maximum likelihood estimator for this variance is constructed and it is proved that it is strongly consistent and asymptotically normal. The main part of our analysis consists in presenting closed matrix forms for this new variance. Additionally, we prove the asymptotic equivalence between the empirical and the maximum likelihood estimation (MLE) for the stationary distribution.     

Large sample interval mapping method for genetic trait loci in finite regression mixture models

This article investigates the large sample interval mapping method for genetic trait loci (GTL) in a finite non-linear regression mixture model. The general model includes most commonly used kernel functions, such as exponential family mixture, logistic regression mixture and generalized linear mixture models, as special cases. The populations derived from either the backcross or intercross design are considered. In particular, unlike all existing results in the literature in the finite mixture models, the large sample results presented in this paper do not require the boundness condition on the parametric space. Therefore, the large sample theory presented in this article possesses general applicability to the interval mapping method of GTL in genetic research. The limiting null distribution of the likelihood ratio test statistics can be utilized easily to determine the threshold values or p-values required in the interval mapping. The limiting distribution is proved to be free of the parameter values of null model and free of the choice of a kernel function. Extension to the multiple marker interval GTL detection is also discussed. Simulation study results show favorable performance of the asymptotic procedure when sample sizes are moderate.     

Robust median estimator in logistic regression

This paper introduces a median estimator of the logistic regression parameters. It is defined as the classical _L1$L_1$-estimator applied to continuous data _Z1,…,_Zn$Z_1,\dots ,Z_n$ obtained by a statistical smoothing of the original binary logistic regression observations _Y1,…,_Yn$Y_1,\dots ,Y_n$. Consistency and asymptotic normality of this estimator are proved. A method called enhancement is introduced which in some cases increases the efficiency of this estimator. Sensitivity to contaminations and leverage points is studied by simulations and compared in this manner with the sensitivity of some robust estimators previously introduced to the logistic regression. The new estimator appears to be more robust for larger sample sizes and higher levels of contamination.     

On the simple linear regression model with correlated measurement errors

The simple linear regression model with measurement error has been subject to much research. In this work we will focus on this model when the error in the explanatory variable is correlated with the error in the regression equation. Specifically, we are interested in the comparison between the ordinary errors-in-variables estimator of the regression coefficient β$\beta$ and the estimator that takes account of the correlation between the errors. Based on large sample approximations, we compare the estimators and find that the estimator that takes account of the correlation should be preferred in most situations. We also compare the estimators in small sample situations. This is done by stochastic simulation. The results show that the estimators behave quite similarly in most of the simulated situations, but that the ordinary errors-in-variables estimator performs considerably worse than the estimator that takes account of the correlation for certain parameter combinations. In addition, we look briefly into the bias introduced by ignoring correlated errors when computing sample correlations, and in predictions.     

More on the restricted ridge regression estimation

Several alternative methods for derivation of the restricted ridge regression estimator (RRRE) are provided. Theoretical comparison and relationship of RRRE with related methods for regression with the multicollinearity problem are described. We also find inter-connections among RRRE, ordinary ridge regression estimator (ORRE), restricted least squares estimator (RLSE), modified ridge regression estimator (MRRE) and restricted modified generalized ridge estimator (RMGRE). Finally, numerical comparison, in addition to theoretical derivation, is also conducted with a Monte Carlo simulation and a real data example.     

Collapsibility of regression coefficients and its extensions

Collapsibility with respect to a measure of association implies that the measure of association can be obtained from the marginal model. We first discuss model collapsibility and collapsibility with respect to regression coefficients for linear regression models. For parallel regression models, we give simple and different proofs of some of the known results and obtain also certain new results. For random coefficient regression models, we define (average) A$A$-collapsibility and obtain conditions under which it holds. We consider Poisson regression and logistic regression models also, and derive conditions for collapsibility and A$A$-collapsibility, respectively. These results generalize some of the results available in the literature. Some suitable examples are also discussed.     

Characterization of minimax linear estimators in linear regression

Two characterization theorems of the minimax linear estimator (Mile) are proven for the case, where the regression parameter varies only in an arbitrary ellipsoid. Furthermore, the existence, uniqueness and admissibility of Mile are shown. The explicit determination of Mile is carried out for a special case.     

One-step M-estimators in the linear model,with dependent errors

We consider the problem of robust M-estimation of a vector of regression parameters, when the errors are dependent. We assume a weakly stationary, but otherwise quite general dependence structure. Our model allows for the representation of the correlations of any time series of finite length. We first construct initial estimates of the regression, scale, and autocorrelation parameters. The initial autocorrelation estimates are used to transform the model to one of approximate independence. In this transformed model, final one-step M-estimates are calculated. Under appropriate assumptions, the regression estimates so obtained are asymptotically normal, with a variance-covariance structure identical to that in the case in which the autocorrelations are known a priori. The results of a simulation study are given. Two versions of our estimator are compared with the L₁ -estimator and several Huber-type M-estimators. In terms of bias and mean squared error, the estimators are generally very close. In terms of the coverage probabilities of confidence intervals, our estimators appear to be quite superior to both the L₁-estimator and the other estimators. The simulations also indicate that the approach to normality is quite fast.     

Edgeworth expansion for signed linear rank statistics with regression constants

An Edgeworth expansion with remainder o(N^?1) is obtained for signed linear rank statistics under suitable assumptions. The theorem is proved for a wide class of score generating functions including the Chi-quantile function by adapting van Zwet's methodand Does's conditioning arguments.     

Optimal discrimination designs for exponential regression models

We investigate optimal designs for discriminating between exponential regression models of different complexity, which are widely used in the biological sciences; see, e.g., Landaw [1995. Robust sampling designs for compartmental models under large prior eigenvalue uncertainties. Math. Comput. Biomed. Appl. 181–187] or Gibaldi and Perrier [1982. Pharmacokinetics. Marcel Dekker, New York]. We discuss different approaches for the construction of appropriate optimality criteria, and find sharper upper bounds on the number of support points of locally optimal discrimination designs than those given by Caratheodory's Theorem. These results greatly facilitate the numerical construction of optimal designs. Various examples of optimal designs are then presented and compared to different other designs. Moreover, to protect the experiment against misspecifications of the nonlinear model parameters, we adapt the design criteria such that the resulting designs are robust with respect to such misspecifications and, again, provide several examples, which demonstrate the advantages of our approach.