Report of the first Asian ISSAM Meeting on the Aging Male

The longer life spans of females compared to males has been attributed to the effects of sex hormones. Since experimental tests of this possibility in humans are unethical, indirect studies have been relied on for evidence. The present study offers such indirect evidence by comparing life spans of female and male opera singers, since sex hormones are known to influence development of voice. Life spans of sopranos were found to be significantly greater than those of lower voice registered contraltos, even after controlling for birth year. Differences among male opera singers were not statistically significant. The data support the hypothesis that females live longer than males because of the beneficial effects of estrogens on longevity-related genes.     

Sopranos but not tenors live longer

The longer life spans of females compared to males has been attributed to the effects of sex hormones. Since experimental tests of this possibility in humans are unethical, indirect studies have been relied on for evidence. The present study offers such indirect evidence by comparing life spans of female and male opera singers, since sex hormones are known to influence development of voice. Life spans of sopranos were found to be significantly greater than those of lower voice registered contraltos, even after controlling for birth year. Differences among male opera singers were not statistically significant. The data support the hypothesis that females live longer than males because of the beneficial effects of estrogens on longevity-related genes.     

Association of bioavailable estradiol levels and testosterone levels with serum albumin levels in elderly men

Estrogens are reported to be the essential sex steroid acting on some male physiological functions, and bioavailable estrogens comprise the free and albumin-bound fractions. Moreover, most of the bioavailable sex steroid is made up of albumin-bound fraction. We examined the age-related change in serum free, albumin-bound and bioavailable estradiol levels in comparison with each fraction of testosterone and its relationship with serum albumin level in elderly men. Albumin-bound as well as bioavailable estradiol levels declined with age, and their decreases were associated much more with the decrease of albumin level than the increase of sex-hormone binding globulin (SHBG) level in sixties and seventies, and similar results were recognized in the level of each fraction of testosterone, suggesting albumin levels have an important role for maintaining bioavailable sex steroid levels in males aged over sixty. Moreover, our study showed that SHBG levels associated inversely with bioavailable sex steroid levels particularly when serum albumin level was low. It seems likely that the decrease of bioavailable estradiol as well as testosterone is induced by the decrease of albumin-bound fractions in combination with the increase of SHBG-bound fractions in males aged over sixty, and that their physical characteristics of aging could be induced by the decrease of albumin-bound fractions caused by the decrease of serum albumin regardless of total sex steroid levels.     

Estrogens for men: Good or bad news

The role of estrogens in male physiology has received little attention until recently. However, it is now becoming more and more evident that estrogens are jar more important for a normal junction of reproduction and non-reproductive junctions in men than supposed. Furthermore, although estrogen has been discussed in the context of a decline in sperm number in men, there are no unequivocal data allowing any conclusion on a negative impact of environmental estrogens on male fertility so jar.     

Testosterone and the breast

Although women have been treated with testosterone (T) for female sexual dysfunction since the 1950s, the role of T in normal female physiology is not yet fully defined. One of the major safety concerns of androgen therapy is whether androgens have a stimulatory effect on the breast that could lead to breast carcinomas. The proposed mechanisms for such stimulation include local estrogen production from the aromatase enzyme complex present in the breast tissue or by the direct stimulation of the androgen receptor. Predominant data from in vitro studies have shown that androgens actually have apoptotic and antiproliferative effects and not stimulatory effects. Animal models have shown similar results to in vitro studies, finding that androgens inhibit breast cancer growth. Prospective and retrospective epidemiological analyses have shown mixed outcomes, with no clear consensus regarding androgen use and breast cancer risk. Hyperandrogenism in patients with polycystic ovarian syndrome with elevated levels of endogenous T is not associated with an increased risk of breast cancer and may, in fact, be protective. Another human model with excess of T is female-to-male transgenderism, in which genotypic women are treated with large doses of exogenous T with no increased risk. High-dose androgen therapy also has been effective in treating patients with advanced breast cancer. Thus, the preponderance of data suggests that T use in females is not associated with an increased risk of breast carcinoma.     

Association of serum calcium with serum sex steroid hormones in men in NHANES III

Abstract

Background: Bone is a positive regulator of male fertility, which indicates a link between regulation of bone remodeling and reproduction or more specifically a link between calcium and androgens. This possibly suggests how calcium is linked to prostate cancer development through its link with the reproductive system. We studied serum calcium and sex steroid hormones in the Third National Health and Nutrition Examination Survey (NHANES III).

Methods: Serum calcium and sex steroid hormones were measured for 1262 men in NHANES III. We calculated multivariable-adjusted geometric means of serum concentrations of total and estimated free testosterone and estradiol, androstanediol glucuronide (AAG), and sex hormone binding globulin (SHBG) by categories of calcium (lowest 5% [<1.16?mmol/L], mid 90%, top 5% [≥1.30?mmol/L]).

Results: Levels of total and free testosterone, total estradiol or AAG did not differ across categories of serum calcium. Adjusted SHBG concentrations were 36.4 for the bottom 5%, 34.2 for the mid 90% and 38.9?nmol/L for the top 5% of serum calcium (P_trend?=?0.006), free estradiol levels were 0.88, 0.92 and 0.80?pg/ml (P_trend?=?0.048).

Conclusions: This link between calcium and sex steroid hormones, in particular the U-shaped pattern with SHBG, may, in part, explain why observational studies have found a link between serum calcium and risk of prostate cancer.     

l-Arginine and tetrahydrobiopterin,but not sodium nitrite partially restored erectile dysfunction in aged rats

This paper gives an overview of our own studies and the literature on the biosynthesis and metabolism of estrogens in elderly men, the estrogen action in the male, and the clinical usefulness of estrogen therapy, including the phytoestrogens. Finally, the paper includes a short review of our knowledge of xenoestrogens and men's sexual health. A strong estrogen-deficient status is seen in male patients with mutations of the estrogen receptors or in cases of deviations of the aromatase gene. On the other hand, there are no clear age-dependent changes in estrogen secretion. But, in men with disorders of glucose metabolism and also of increased body mass index, the serum estrogen concentrations are significantly elevated. There are also strong positive correlations between serum estrogen levels and bone density, including prevalence of fractures and mood in men. New fields of interest are natural fatty esters of endogenous estrogens, e.g. lipoprotein-associated estrogens, and the role and clinical significance of tissue-specific, local estrogen biosynthesis (e.g. different promoters of the aromatase gene). Exogenous estrogen treatment is focused today on patients with normal testosterone and low levels of circulating estrogens documented on several occasions and with clinical symptoms of hormone deficiency; male-to-female transsexuals; and selected patients with prostate cancer. Some clinical studies show the benefits of estrogen treatment on some cardiovascular parameters and for treating selected signs of mental stress. An indirect estrogen replacement can occur if dehydroepiandrosterone is given orally to men. The clinical usefulness of dissociated estrogens, including non-feminizing estrogens and selective estrogen receptor modulators, is still an open question. The beneficial action of phytoestrogens in lowering the clinical symptoms of benign prostatic hyperplasia is well documented. Finally, the question about the definitive influence of so-called endocrine disruptors (xenoestrogens) on sexual functions in men is also discussed.     

Testosterone and penile erection

Male sexual function depends upon a complex inter-relationship between psychological, neurological, vascular and hormonal factors. Testosterone is responsible for the initiation, development and maintenance of primary and secondary sexual characteristics as well as having a role in male sexual behavior and potency. In adults, testosterone deficiency is associated with reduced libido and potency, infertility, lethargy and a number of behavioral modifications. This article reviews what is known about the role of testosterone on the mechanism of penile erection and describes the results of the experimental designs and animals models used in the study of erectile physiology. In animals, testosterone seems to have an action on some neurotransmitters of erectile mechanism, while in man, its role is mainly on the behavioral aspects.     

Source‐Country Gender Roles and the Division of Labor Within Immigrant Families

The authors examined the relationship between source‐country gender roles and the gender division of paid and unpaid labor within immigrant families in the host society. Results from Canadian Census of Population (N = 497,973) data show that the 2 indicators of source‐country gender roles examined—female/male labor activity ratio and female/male secondary education ratio—are both positively associated with immigrant wives' share in their family labor supply and negatively associated with their share in housework. The association between source‐country gender roles and women's share in couples' labor activities weakens over time. Moreover, the relationship between source‐country female/male labor activity and immigrant couples' gender division of labor is reduced when immigrant women have nonimmigrant husbands, indicating that husband's immigration status matters.     

The use of selective estrogen receptor modulators on bone health in men

Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, whereby patients undergo androgen deprivation therapy is often associated with deleterious effects on bone. Previous preclinical and epidemiological findings showed that estrogens play a dominant role in improving bone health as compared to testosterone in men. Therefore, this evidence-based review aims to assess the available evidence derived from animal and human studies on the effects of SERMs on the male skeletal system. The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review.     

Menopause and sexual desire: the role of testosterone

The present short review underlines the role of testosterone (T) in the motivational and satisfaction components of women's sexuality and critically discusses the strategies to treat hypoactive sexual desire disorder (HSDD), a condition of low desire associated with personal and/or interpersonal difficulties, which is more common in surgical menopausal women. There are multiple ways androgens target the brain regions (hypothalamic, limbic and cortical) involved in sexual function and behaviour. Even though circulating available androgens have been implicated in several domains of sexual response, they seem to be related weakly to symptoms, such as low sexual desire, poor sexual arousal, orgasm and diminished well-being in postmenopausal women. The possibilities of treating low sexual desire/HSDD are multifaceted and should include the combination of pharmacological treatments able to maximize biological signals driving the sexual response, and individualized psychosocial therapies in order to overcome personal and relational difficulties. Transdermal T has been shown to be effective at a dose of 300 μg/day both in surgically and naturally menopausal women replaced with estrogen or not, without any relevant side-effects. However, the decision to treat postmenopausal women with HSDD with T is mainly based on clinical judgement, after informed consent regarding the unknown long-term risks.     

Promoting Global Citizenship Through Study Abroad: The Influence of Program Destination, Type, and Duration on the Propensity for Development Volunteerism

Study abroad is cited commonly as a critical element of education for global civic engagement, but the significance of various programmatic features has not been well established. This study examines the relationships among three facets of study abroad programs—destination, type, and duration—and subsequent volunteerism through international development organizations. Survey responses were analyzed from 2,250 college alumni (71 % female, 14 % ethnic minority, M age = 27) who studied abroad between 1995 and 2005. The results of logistic regression indicated that studying abroad in a developing country and engaging in international service-learning were positively associated with the odds of development volunteerism. The number of months spent abroad also predicted development volunteerism, though duration did not moderate the effects of program destination and type. An interaction test demonstrated that program effects were not dependent on gender. The findings suggest that differences in the nature of study abroad programs influence the extent to which participants become actively engaged in global civil society.     

Feminist Insight on Gendered Work: New Directions in Research on Women and Entrepreneurship

This paper discusses research on female entrepreneurs in conjunction with feminist theory on gendered work. I explore the ways in which much of the research on women's experiences of entrepreneurship focuses on identifying similarities and differences between female and male business owners, and on providing explanations for the differences identified. While such an approach is useful in compensating for the exclusion of women in earlier studies of business ownership, it does not illuminate how and why entrepreneurship came to be defined and understood vis-à-vis the behaviour of only men. I argue that existing knowledge on women business owners could be enhanced through reflection on two issues — first, on the essentialism in the very construction of the category of ‘the female entrepreneur’ (which prioritizes sex over other dimensions of stratification) and second, on the ways in which the connections between gender, occupation and organizational structure differently affect female and male business owners.     

Nightlife Girls: Envy,Theatre, and Encounters with Men and Women

This article explores how envy influences affective performance in the service industry. Utilizing the first‐person accounts of 12 women working in one Manhattan bar, it examines how the experiences these women have with male and female customers are differently intersected by expectations for gendered performance. It further explores how envy — as the emotion most prompted in the servers in the face of these expectations — can in response be harnessed as a force for their critical agency. Seeing envy as both an antagonizer and central defence mechanism, the paper goes on to dissect the various strategies employed by the serving women to both adopt the differing embodiments of affective gender performance expected by their male and female customers, and protect themselves from the emotional damage that is risked in adopting such externally dictated subjectivities.     

A Localized Masculine Crisis: Local Men's Subordination within the Marcellus Shale Region's Masculine Structure

Rural economic decline in the United States has contributed to new situational conditions under which men construct masculinity. Under these conditions, men define jobs and activities that were feminized during periods of economic stability as masculine. One exception to rural economic decline for men is economic growth associated with oil and natural gas development in geographical hot spots throughout the United States and around the world. Employment opportunities in the oil and gas industry largely favor men; however, it is unclear what effect this development has on local men because itinerant extralocal male workers complete most of the labor. This article conceptualizes masculinity as a social structure, and uses economic reports and theoretically distinct literatures on natural‐resource‐based masculinities and energy boomtowns to illuminate how multinational energy companies and a predominantly extralocal, male itinerant workforce in Pennsylvania's Marcellus Shale region cause adverse situational conditions for local men's constructions of masculinity. Within the new masculine structure, extralocal men's constructions of hegemonic masculinity become more important for defining the local socially dominant masculinity, which subordinates local men's constructions of nonhegemonic masculinities in their own communities. The article concludes with a discussion of how the oil and gas industry's hegemonic masculinity impedes sustainable economic development and community well‐being.     

Age related variation of salivary testosterone values in healthy Japanese males

Objective. We examined age associated variation in salivary testosterone values among Japanese males as well as anthropometric measurements.

Methods. Salivary samples were collected in pretreated sodium azide treated tubes. The first series: 15–79-year-old males (n = 99); two morning and two evening samples were collected at home for two days. The second series: 90-year-old males (n = 29); one morning sample was collected. Testosterone values were determined using an iodine125-based radioimmunoassay kit modified for saliva.

Results. Results show 1) a significant decrease in salivary testosterone values from 20s to 40s and older, 2) no significant decline after 40 through 90 years old, 3) no significant age-related differences in the degree of intraindividual diurnal fluctuation across age groups of 40–70s, and 4) higher BMI is associated with the lower salivary testosterone among 40–70s.

Conclusions. These results suggest that neither a constant decrease of salivary testosterone values or markedly reduced intraindividual fluctations are universal aspects of aging. Older males may maintain relatively high testosterone levels compared to younger men and a relatively ‘robust’ neuroendocrinological system.     

Toward Understanding Another Gender Gap: How Women in Economic Development Perceive Access to Capital

This study uses survey data collected from members of the International Economic Development Council (IEDC) to assess gender differences in the perceptions of female economic developers involved in the policy process. The analysis reveals women are more likely than their male counterparts to believe access to capital serves as a barrier to economic development in the communities they serve. This finding is important because bureaucratic perceptions are anticipated to have a gendered dimension, because there is ample evidence that women-owned businesses less frequently obtain external financing than do those owned by men. This obstacle to growing a business may therefore resonate more strongly with female economic developers if their perceptions reflect experiences and socialization processes shared with the women they represent. Results of an ordinal logistic regression model support this contention and contribute to the study of economic development and the role of women in the policy process.