An Automatic Test for the Umbrella Alternatives

The paper proposes a new test for detecting the umbrella pattern under a general non‐parametric scheme. The alternative asserts that the umbrella ordering holds while the hypothesis is its complement. The main focus is put on controlling the power function of the test outside the alternative. As a result, the asymptotic error of the first kind of the constructed solution is smaller than or equal to the fixed significance level α on the whole set where the umbrella ordering does not hold. Also, under finite sample sizes, this error is controlled to a satisfactory extent. A simulation study shows, among other things, that the new test improves upon the solution widely recommended in the literature of the subject. A routine, written in R, is attached as the Supporting Information file.     

Iso‐chi‐squared testing of 2 × k: ordered tables

The Pearson chi‐squared statistic for testing the equality of two multinomial populations when the categories are nominal is much less appropriate for ordinal categories. Test statistics typically used in this context are based on scorings of the ordinal levels, but the results of these tests are highly dependent on the choice of scores. The authors propose a test which naturally modifies the Pearson chi‐squared statistic to incorporate the ordinal information. The proposed test statistic does not depend on the scores and under the null hypothesis of equality of populations, it is asymptotically equivalent to the likelihood ratio test against the alternative of two‐sided likelihood ratio ordering.     

Permutation Approaches for Stochastic Ordering

In many application problems, when dealing with comparisons between two or more groups, the classical parametric inferential statistical methods are used, although in real problems the quite stringent assumptions required by such methods are rarely satisfied. In particular a parametric approach to the test on ordering of C > 2 populations is very difficult. In order to tackle this problem two alternative methods are proposed in the present paper. Both the methods consist in permutation combination based tests: the first is supposed to be more powerful and it is suitable when the main goal of the study is related to the global ordering of the populations; the second is useful when the interest is in the pairwise comparisons between the populations.     

Nonparametric Two‐Sample Tests of the Marginal Mark Distribution with Censored Marks

Occasionally, investigators collect auxiliary marks at the time of failure in a clinical study. Because the failure event may be censored at the end of the follow‐up period, these marked endpoints are subject to induced censoring. We propose two new families of two‐sample tests for the null hypothesis of no difference in mark‐scale distribution that allows for arbitrary associations between mark and time. One family of proposed tests is a nonparametric extension of an existing semi‐parametric linear test of the same null hypothesis while a second family of tests is based on novel marked rank processes. Simulation studies indicate that the proposed tests have the desired size and possess adequate statistical power to reject the null hypothesis under a simple change of location in the marginal mark distribution. When the marginal mark distribution has heavy tails, the proposed rank‐based tests can be nearly twice as powerful as linear tests.     

A modified Mack–Wolfe test for the umbrella alternative problem

ABSTRACT

The Mack–Wolfe test is the most frequently used non parametric procedure for the umbrella alternative problem. In this paper, modifications of the Mack–Wolfe test are proposed for both known peak and unknown peak umbrellas. The exact mean and variance of the proposed tests in the null hypothesis are also derived. We compare these tests with some of the existing tests in terms of the type I error rate and power. In addition, a real data example is presented.     

Inference for comparing a multinomial distribution with a known standard

We propose a new type of stochastic ordering which imposes a monotone tendency in differences between one multinomial probability and a known standard one. An estimation procedure is proposed for the constrained maximum likelihood estimate, and then the asymptotic null distribution is derived for the likelihood ratio test statistic for testing equality of two multinomial distributions against the new stochastic ordering. An alternative test is also discussed based on Neyman modified minimum chi-square estimator. These tests are illustrated with a set of heart disease data.     

DISTRIBUTION-FREE CONFIDENCE PROCEDURE FOR UMBRELLA ORDERINGS

Responses in a one-factor experiment with A; ordered treatments follow an umbrella, ordering if they consist of two piecewise monotone segments, i.e. increasing and then decreasing, or the converse. This paper proposes a non-parametric distribution-free confidence procedure for umbrella orderings, the aim being to identify the treatments that correspond to the optimal effects. It uses a method that joins the seemingly unrelated theories of U-statistics and isotonic regression. A random confidence subset of the ordered treatments is constructed, such that it contains all the unknown peaks (optimal treatments) of an umbrella ordering with any prespecified confidence level. The paper demonstrates that the proposed confidence procedure is nonparametric distribution-free and, further, that the proposed procedure naturally implies a test for umbrella alternatives. Since the proposed confidence procedure is always more informative than tests for umbrella alternatives, it should be used in their place in practice. An example illustrates the proposed procedure.     

On the Comparison of Two Ordinal Responses

Responses of two groups, measured on the same ordinal scale, are compared through the column effect association model, applied on the corresponding 2 × J contingency table. Monotonic or umbrella shaped ordering for the scores of the model are related to stochastic or umbrella ordering of the underlying response distributions, respectively. An algorithm for testing all possible hypotheses of stochastic ordering and deciding on an appropriate one is proposed.     

New tests for stochastic order with application to case control studies

It is shown that if a binary regression function is increasing then retrospective sampling induces a stochastic ordering of the covariate distributions among the responders, which we call cases, and the non-responders, which we call controls. We also show that if the covariate distributions are stochastically ordered then the regression function must be increasing. This means that testing whether the regression function is monotone is equivalent to testing whether the covariate distributions are stochastically ordered. Capitalizing on these new probabilistic observations we proceed to develop two new non-parametric tests for stochastic order. The new tests are based on either the maximally selected, or integrated, chi-bar statistic of order one. The tests are easy to compute and interpret and their large sampling distributions are easily found. Numerical comparisons show that they compare favorably with existing methods in both small and large samples. We emphasize that the new tests are applicable to any testing problem involving two stochastically ordered distributions.     

Which Wald statistic? Choosing a parameterization of the Wald statistic to maximize power in k-sample generalized estimating equations

The Wald statistic is known to vary under reparameterization. This raises the question: which parameterization should be chosen, in order to optimize power of the Wald statistic? We specifically consider k-sample tests of generalized linear models (GLMs) and generalized estimating equations (GEEs) in which the alternative hypothesis contains only two parameters. An example is presented in which such an alternative hypothesis is of interest. Amongst a general class of parameterizations, we find the parameterization that maximizes power via analysis of the non-centrality parameter, and show how the effect on power of reparameterization depends on sampling design and the differences in variance across samples. There is no single parameterization with optimal power across all alternatives. The Wald statistic commonly used under the canonical parameterization is optimal in some instances but it performs very poorly in others. We demonstrate results by example and by simulation, and describe their implications for likelihood ratio statistics and score statistics. We conclude that due to poor power properties, the routine use of score statistics and Wald statistics under the canonical parameterization for GEEs is a questionable practice.     

Unbiased tests for some one-sided testing problems

Unbiased tests are found for various testing problems. In the first model considered we test homogeneity of k + 1 independent one-parameter exponential family populations vs. the tree-top ordering alternative. The tree-top alternative is appropriate for one-sided comparisons for treatments with a control. In the next set of models normality is assumed. In one such model k independent populations have different unknown means but have an unknown common variance. An independent estimate of the variance exists. We test homogeneity of means against the alternative of no homogeneity. We also consider the alternative of an ordering of the means as well as the tree-top ordering. The final model considered is when we take a random sample from a multivariate normal population with unknown mean vector and an unknown covariance matrix of the intraclass type. We test the hypothesis that the mean vector is the zero vector against the one-sided alternative that each mean is nonnegative (with at least one positive).     

On tail-ordering and comparison of failure rates

In this paper, we have studied some implications between tail-ordering (also known as dispersive ordering) and failure rate ordering (also called TP₂ ordering) of two probability distribution functions. Based on independent random samples from these distributions, a class of distribution-free tests has been proposed for testing the null hypothesis that the two life distributions are identical against the alternative that one failure rate is uniformly smaller than the other. The tests have good efficiencies as compared to their competitors.     

Precedence-type test based on Kaplan–Meier estimator of cumulative distribution function

In this paper, we introduce a precedence-type test based on Kaplan–Meier estimator of cumulative distribution function (CDF) for testing the hypothesis that two distribution functions are equal against a stochastically ordered hypothesis. This test is an alternative to the precedence life-test proposed first by Nelson (1963). After deriving the null distribution of the test statistic, we present its exact power function under the Lehmann alternative, and compare the exact power as well as simulated power (under location-shift) of the proposed test with other precedence-type tests. Next, we extend this test to the case of progressively Type-II censored data. Critical values for some combination of sample sizes and progressive censoring schemes are presented. We then examine the power properties of this test procedure and compare them to those of the weighted precedence and weighted maximal precedence tests under a location-shift alternative by means of Monte Carlo simulations. Finally, we present two examples to illustrate all the test procedures discussed here, and then make some concluding remarks.     

Nonparametric tests of hypotheses for umbrella alternatives

The author proposes a general method for constructing nonparametric tests of hypotheses for umbrella alternatives. Such alternatives are relevant when the treatment effect changes in direction after reaching a peak. The author's class of tests is based on the ranks of the observations. His general approach consists of defining two sets of rankings: the first is induced by the alternative and the other by the data itself. His test statistic measures the distance between the two sets. The author determines the asymptotic distribution for some special cases of distances under both the null and the alternative hypothesis when the location of the peak is known or unknown. He shows the good power of his tests through a limited simulation study     

Power and sample size calculation for paired right-censored data based on survival copula models

Sample size determination is essential during the planning phases of clinical trials. To calculate the required sample size for paired right-censored data, the structure of the within-paired correlations needs to be pre-specified. In this article, we consider using popular parametric copula models, including the Clayton, Gumbel, or Frank families, to model the distribution of joint survival times. Under each copula model, we derive a sample size formula based on the testing framework for rank-based tests and non-rank-based tests (i.e., logrank test and Kaplan–Meier statistic, respectively). We also investigate how the power or the sample size was affected by the choice of testing methods and copula model under different alternative hypotheses. In addition to this, we examine the impacts of paired-correlations, accrual times, follow-up times, and the loss to follow-up rates on sample size estimation. Finally, two real-world studies are used to illustrate our method and R code is available to the user.     

The one-way analysis of variance with ordered alternatives: A modification of bartholomew's Ē2 Test

Tests of homogeneity of normal means with the alternative restricted by an ordering on the means are considered. The simply ordered case, μ₁ ≤ μ₂ ≤ ··· ≤ μ_k, and the simple tree ordering, μ₁ ≤ μ_j, for; j= 2, 3,…, k, are emphasized. A modification of the likelihood-ratio test is proposed which is asymptotically equivalent to it but is more robust to violations of the hypothesized orderings. The new test has power at the points satisfying the hypothesized ordering which is similar to that of the likelihood-ratio test provided the degrees of freedom are not too small. The modified test is shown to be unbiased and consistent.     

The power functions of the likelihood ratio tests for a simple tree ordering in normal means: unequal weights

Likelihood ratio tests are considered for two testing situations; testing for the homogeneity of k normal means against the alternative restricted by a simple tree ordering trend and testing the null hypothesis that the means satisfy the trend against all alternatives. Exact expressions are given for the power functions for k = 3 and 4 and unequal sample sizes, both for the case of known and unknown population variances, and approximations are discussed for larger k. Also, Bartholomew’s conjectures concerning minimal and maximal powers are investigated for the case of equal and unequal sample sizes. The power formulas are used to compute powers for a numerical example.     

Comparing Survival Times for Treatments with Those for a Control Under Proportional Hazards

Inferences for survival curves based on right censored data are studied for situations in which it is believed that the treatments have survival times at least as large as the control or at least as small as the control. Testing homogeneity with the appropriate order restricted alternative and testing the order restriction as the null hypothesis are considered. Under a proportional hazards model, the ordering on the survival curves corresponds to an ordering on the regression coefficients. Approximate likelihood methods, which are obtained by applying order restricted procedures to the estimates of the regression coefficients, and ordered analogues to the log rank test, which are based on the score statistics, are considered. Mau's (1988) test, which does not require proportional hazards, is extended to this ordering on the survival curves. Using Monte Carlo techniques, the type I error rates are found to be close to the nominal level and the powers of these tests are compared. Other order restrictions on the survival curves are discussed briefly.     

Weighted Mean Survival Test Statistics: a Class of Distance Tests for Censored Survival Data

A class of test statistics is introduced which is sensitive against the alternative of stochastic ordering in the two-sample censored data problem. The test statistics for evaluating a cumulative weighted difference in survival distributions are developed while taking into account the imbalances in base-line covariates between two groups. This procedure can be used to test the null hypothesis of no treatment effect, especially when base-line hazards cross and prognostic covariates need to be adjusted. The statistics are semiparametric, not rank based, and can be written as integrated weighted differences in estimated survival functions, where these survival estimates are adjusted for covariate imbalances. The asymptotic distribution theory of the tests is developed, yielding test procedures that are shown to be consistent under a fixed alternative. The choice of weight function is discussed and relies on stability and interpretability considerations. An example taken from a clinical trial for acquired immune deficiency syndrome is presented.     

Heteroscedasticity diagnostics in varying-coefficient partially linear regression models and applications in analyzing Boston housing data

It is important to detect the variance heterogeneity in regression model because efficient inference requires that heteroscedasticity is taken into consideration if it really exists. For the varying-coefficient partially linear regression models, however, the problem of detecting heteroscedasticity has received very little attention. In this paper, we present two classes of tests of heteroscedasticity for varying-coefficient partially linear regression models. The first test statistic is constructed based on the residuals, in which the error term is from a normal distribution. The second one is motivated by the idea that testing heteroscedasticity is equivalent to testing pseudo-residuals for a constant mean. Asymptotic normality is established with different rates corresponding to the null hypothesis of homoscedasticity and the alternative. Some Monte Carlo simulations are conducted to investigate the finite sample performance of the proposed tests. The test methodologies are illustrated with a real data set example.