Lagged Regression Residuals and Serial-Correlation Tests

A new family of statistics is proposed to test for the presence of serial correlation in linear regression models. The tests are based on partial sums of lagged cross-products of regression residuals that define a class of interesting Gaussian processes. These processes are characterized in terms of regressor functions, the serial-correlation structure, the distribution of the noise process, and the order of the lag of the cross-products of residuals. It is shown that these four factors affect the lagged residual processes independently. Large-sample distributional results are presented for test statistics under the null hypothesis of no serial correlation or for alternatives from a range of interesting hypotheses. Some indication of the circumstances to which the asymptotic results apply in finite-sample situations and of those to which they should be applied with some caution are obtained through a simulation study. Tables of selected quantiles of the proposed tests are also given. The tests are illustrated with two examples taken from the empirical literature. It is also proposed that plots of lagged residual processes be used as diagnostic tools to gain insight into the correlation structure of residuals derived from regression fits.     

Closure properties of classes of multiple testing procedures

Statistical discoveries are often obtained through multiple hypothesis testing. A variety of procedures exists to evaluate multiple hypotheses, for instance the ones of Benjamini–Hochberg, Bonferroni, Holm or Sidak. We are particularly interested in multiple testing procedures with two desired properties: (solely) monotonic and well-behaved procedures. This article investigates to which extent the classes of (monotonic or well-behaved) multiple testing procedures, in particular the subclasses of so-called step-up and step-down procedures, are closed under basic set operations, specifically the union, intersection, difference and the complement of sets of rejected or non-rejected hypotheses. The present article proves two main results: First, taking the union or intersection of arbitrary (monotonic or well-behaved) multiple testing procedures results in new procedures which are monotonic but not well-behaved, whereas the complement or difference generally preserves neither property. Second, the two classes of (solely monotonic or well-behaved) step-up and step-down procedures are closed under taking the union or intersection, but not the complement or difference.     

Testing noninferiority in three‐armed clinical trials based on likelihood ratio statistics

Clinical noninferiority trials with at least three groups have received much attention recently, perhaps due to the fact that regulatory agencies often require that a placebo group be evaluated along with a new experimental drug and an active control. The authors discuss likelihood ratio tests for binary endpoints and various noninferiority hypotheses. They find that, depending on the particular hypothesis, the test reduces asymptotically either to the intersection‐union test or to a test which follows asymptotically a mixture of generalized chi‐squared distributions. They investigate the performance of this asymptotic test and provide an exact modification. They show that this test considerably outperforms multiple testing methods such as the Bonferroni adjustment with respect to power. They illustrate their methods with a cancer study to compare antiemetic agents. Finally, they discuss the extension of the results to other settings, such as Gaussian endpoints.     

Unified treatment of Cramér-Rao bound for the nonregular density functions

This paper extends the idea of Vincze (1978) and unifies the approach for the uniparameter and multiparameter situations for obtaining the Cramér-Rao inequality.     

Union-intersection rank tests for ordered alternatives in some simple linear models

The theory of locally most powerful rank tests and the union intersection principle are incorporated in the formulation of some distribution-free rank tests for ordered alternatives in some simple linear models (including the classical one-way layout as a special case). Some approximations for the null-hypothesis distributions of the test statistics ( for finite sample sizes) are considered, and the theory is supplemented by some numerical and simulation results.     

Multivariate testing and model-checking for generalized order statistics with applications

The exponential family structure of the joint distribution of generalized order statistics is utilized to establish multivariate tests on the model parameters. For simple and composite null hypotheses, the likelihood ratio test (LR test), Wald's test, and Rao's score test are derived and turn out to have simple representations. The asymptotic distribution of the corresponding test statistics under the null hypothesis is stated, and, in case of a simple null hypothesis, asymptotic optimality of the LR test is addressed. Applications of the tests are presented; in particular, we discuss their use in reliability, and to decide whether a Poisson process is homogeneous. Finally, a power study is performed to measure and compare the quality of the tests for both, simple and composite null hypotheses.     

On testing hypotheses with divergence statistics

Using divergence measures based on entropy functions, a procedure to test statistical hypotheses is proposed. Replacing the parameters by suitable estimators in the expresion of the divergence measure, the test statistics are obtained. Asymptotic distributions for these statistics are given in several cases when maximum likelihood estimators are considered, so they can be used to construct confidence intervals and to test statistical hypotheses based on one or more samples. These results can also be applied to multinomial populations. Tests of goodness of fit and tests of homogeneity can be constructed.     

A Correction Note on Improvement in Variance Estimation Using Auxiliary Information

ABSTRACT

In this paper, the testing problem for homogeneity in the mixture exponential family is considered. The model is irregular in the sense that each interest parameter forms a part of the null hypothesis (sub-null hypothesis) and the null hypothesis is the union of the sub-null hypotheses. The generalized likelihood ratio test does not distinguish between the sub-null hypotheses. The Supplementary Score Test is proposed by combining two orthogonalized score tests obtained corresponding to the two sub-null hypotheses after proper reparameterization. The test is easy to design and performs better than the generalized likelihood ratio test and other alternative tests by numerical comparisons.     

Higher order C(α) tests with applications to mixture models

A class of second-order C(α) tests is proposed for testing composite hypotheses when no optimal test among the (first-order) C(α) tests, as defined by Neyman (Probability and Statistics, The Harald Cramer Volume, Almqvist and Wiksell, Uppsala, Sweden, 1959, p. 213), exists. The form of an optimal test of the new subclass is also presented. The procedure is seen to be easily extendable to C(α) tests of third or higher orders. Two examples of univariate normal mixtures are considered where the procedure is successfully applied. For the corresponding multivariate models, union–intersection tests of Roy (Ann. Math. Statist. 24 (1953) 220) are derived by combining the above optimal tests of the univariate problems.     

A survey on multivariate chi-square distributions and their applications in testing multiple hypotheses

We are concerned with three different types of multivariate chi-square distributions. Their members play important roles as limiting distributions of vectors of test statistics in several applications of multiple hypotheses testing. We explain these applications and consider the computation of multiplicity-adjusted p-values under the respective global hypothesis. By means of numerical examples, we demonstrate how much gain in level exhaustion or, equivalently, power can be achieved with corresponding multivariate multiple tests compared with approaches which are only based on univariate marginal distributions and do not take the dependence structure among the test statistics into account. As a further contribution of independent value, we provide an overview of essentially all analytic formulas for computing multivariate chi-square probabilities of the considered types which are available up to present. These formulas were scattered in the previous literature and are presented here in a unified manner.     

ADF单位根检验中联合检验LM统计量研究

 本文研究了ADF单位根检验中参数联合约束的拉格朗日乘数检验。首先,本文构建了4个LM统计量并推导了它们的极限分布;然后,运用蒙特卡罗试验,模拟了有限样本容量常用检验水平下的临界值,拟合了临界值关于样本容量的响应面函数,并总结了LM统计量有限样本容量下的统计特性;比较分析了这4个LM统计量的检验功效及实际检验水平;最后,一个实例分析简要说明了这几个统计量在单位根检验中的应用。     

Confidence interval estimation and hypothesis testing for a common correlation coefficient

Several procedures have been proposed for testing the hypothesis that all off-diagonal elements of the correlation matrix of a multivariate normal distribution are equal. If the hypothesis of equal correlation can be accepted, it is then of interest to estimate and perhaps test hypotheses for the common correlation. In this paper, two versions of five different test statistics are compared via simulation in terms of adequacy of the normal approximation, coverage probabilities of confidence intervals, control of Type I error, and power. The results indicate that two test statistics based on the average of the Fisher z-transforms of the sample correlations should be used in most cases. A statistic based on the sample eigenvalues also gives reasonable results for confidence intervals and lower-tailed tests.     

RAO'S SCORE TESTS IN SURVIVAL ANALYSIS: EXAMPLES AND BARTLETT TYPE ADJUSTMENTS

Score method in hypothesis testing is one of Professor C. R. Rao's great contributions to statistics. It provides a simple and unified way to test some simple and composite hypotheses in many statistical problems. Some popular tests in statistical practice derived with the help of intuitions can be shown as score tests under some statistical models. The subject-years test and log-rank test in survival analysis are two of the examples. In this paper, we first introduce these two examples. After formulating these two tests as score tests, we then review some recent results on the Bartlett type adjustments for these tests.     

On group sequential tests for data in unequally sized groups and with unknown variance

We present a method to generalise the scope of application of group sequential tests designed for equally sized groups of normal observations with known variance. Preserving the significance levels against which standardised statistics are compared leads to tests for unequally grouped data which maintain Type I error probabilities to a high degree of accuracy. The same approach can be followed when observations have unknown variance by setting critical values for Studentised statistics at percentiles of the appropriate t-distributions. This significance level approach is equally applicable to group sequential one-sided tests and two-sided tests, possibly with early stopping permitted to accept the null hypothesis. In applications to equivalence testing, tests are required to maintain a specified power, rather than Type I error rate: such tests can be constructed by defining the standardised test statistics used in the significance level approach with respect to appropriately chosen hypotheses.     

Extensions of empirical likelihood and chi-squared-based tests for ordered alternatives

Several methods for comparing k populations have been proposed in the literature. These methods assess the same null hypothesis of equal distributions but differ in the alternative hypothesis they consider. We focus on two important alternative hypotheses: monotone and umbrella ordering. Two new families of test statistics are proposed, including two known tests, as well as two new powerful tests under monotone ordering. Furthermore, these families are adapted for testing umbrella ordering. We compare some members of the families with respect to power and Type I errors under different simulation scenarios. Finally, the methods are illustrated in several applications to real data.     

A new test for exponentiality against HNBUE alternatives

Abstract

Two families of test statistics for testing the null hypothesis of exponentiality against Harmonic New Better than Used in Expectation (HNBUE) alternatives are proposed. Asymptotic distributions of the test statistics are derived under the null and alternative hypotheses and the consistency of the tests established. Comparison with competing tests are made in terms of Pitman Asymptotic Relative Efficiency (PARE). Simulation studies have been carried out to assess the performance of the tests. Finally, the test has been applied to three real life data sets described in Proschan, Susarla and Van Ryzin and Engelhardt, Bain and Wright.     

Rényi statistics for testing composite hypotheses in general exponential models

We introduce a family of Rényi statistics of orders r?∈?R for testing composite hypotheses in general exponential models, as alternatives to the previously considered generalized likelihood ratio (GLR) statistic and generalized Wald statistic. If appropriately normalized exponential models converge in a specific sense when the sample size (observation window) tends to infinity, and if the hypothesis is regular, then these statistics are shown to be χ²-distributed under the hypothesis. The corresponding Rényi tests are shown to be consistent. The exact sizes and powers of asymptotically α-size Rényi, GLR and generalized Wald tests are evaluated for a concrete hypothesis about a bivariate Lévy process and moderate observation windows. In this concrete situation the exact sizes of the Rényi test of the order r?=?2 practically coincide with those of the GLR and generalized Wald tests but the exact powers of the Rényi test are on average somewhat better.     

Sample size determination in fixed‐dose combination drug studies

In this paper, the application of the intersection–union test method in fixed‐dose combination drug studies is discussed. An approximate sample size formula for the problem of testing the efficacy of a combination drug using intersection–union tests is proposed. The sample sizes obtained from the formula are found to be reasonably accurate in terms of attaining the target power 1?β for a specified β. Copyright © 2003 John Wiley & Sons, Ltd.     

Nonparametric multiple comparison procedures for unbalanced one-way factorial designs

In this paper, we present several nonparametric multiple comparison (MC) procedures for unbalanced one-way factorial designs. The nonparametric hypotheses are formulated by using normalized distribution functions and the comparisons are carried out on the basis of the relative treatment effects. The proposed test statistics take the form of linear pseudo rank statistics and the asymptotic joint distribution of the pseudo rank statistics for testing treatments versus control satisfies the multivariate totally positive of order two condition irrespective of the correlations among the rank statistics. Therefore, in the context of MCs of treatments versus control, the nonparametric Simes test is validated for the global testing of the intersection hypothesis. For simultaneous testing of individual hypotheses, the nonparametric Hochberg stepup procedure strongly controls the familywise type I error rate asymptotically. With regard to all pairwise comparisons, we generalize various single-step and stagewise procedures to perform comparisons on the relative treatment effects. To further compare with normal theory counterparts, the asymptotic relative efficiencies of the nonparametric MC procedures with respect to the parametric MC procedures are derived under a sequence of Pitman alternatives in a nonparametric location shift model for unbalanced one-way layouts. Monte Carlo simulations are conducted to demonstrate the validity and power of the proposed nonparametric MC procedures.     

WILCOXON-TYPE RANK-SUM PRECEDENCE TESTS

This paper introduces Wilcoxon‐type rank‐sum precedence tests for testing the hypothesis that two life‐time distribution functions are equal. They extend the precedence life‐test first proposed by Nelson in 1963. The paper proposes three Wilcoxon‐type rank‐sum precedence test statistics—the minimal, maximal and expected rank‐sum statistics—and derives their null distributions. Critical values are presented for some combinations of sample sizes, and the exact power function is derived under the Lehmann alternative. The paper examines the power properties of the Wilcoxon‐type rank‐sum precedence tests under a location‐shift alternative through Monte Carlo simulations, and it compares the power of the precedence test, the maximal precedence test and Wilcoxon rank‐sum test (based on complete samples). Two examples are presented for illustration.