An extension of Banerjee and Rahim model in economic and economic statistical designs for multivariate quality characteristics under Burr XII distribution

The design parameters of the economic and economic statistical designs of control charts depend on the distribution of process failure mechanism or shock model. So far, only a small number of failure distributions, such as exponential, gamma, and Weibull with fixed or increasing hazard rates, have been used as a shock model in the economic and economic statistical designs of the Hotelling T² control charts. Due to both theoretical and practical aspects, the lifetime of the process under study may not follow a distribution with fixed or increasing hazard rate. A proper alternative for this situation may be the Burr distribution, in which the hazard rate can be fixed, increasing, decreasing, single mode, or even U-shaped. In this research article, economic and economic statistical designs of the Hotelling T² control charts under the Burr XII shock models under two uniform and non uniform sampling schemes were proposed, constructed, and compared. The obtained design models were implemented by a numerical example, and a sensitivity analysis was conducted to evaluate the effect of changing parameters of shock model distribution on the optimum values of the proposed design models. The results showed that first the proposed designs under non uniform sampling scheme perform better and second the optimum values of the designs are not significantly sensitive to changing of the Burr XII distribution parameters. We showed that the obtained design models are also true for the beta Burr XII shock model.     

Some approaches to statistical analysis of a weather modification experiment

Data from a weather modification experiment are examined and a number of statistical analyses reported. The validity of earlier inferences is studied as are the utilities of various statistical methods. The experiment is described. The original analysis of North American Weather Consultants, who conducted the experiment, is reviewed. Data summarization is reported. A major approach to analysis is through the use of cloud-physics covari-ates in regression analyses. Finally, a multivariate analysis is discussed. It appears that the covariates may have been affected by treatment (cloud seeding) and that their use is invalid, not only reducing error variances but removing treatment effect. Some recommendations for improved design of similar future experiments are given in a concluding section, including preliminary trial use of blocking by storms.     

Constructions of efficiency-balanced designs

We present a number of methods of constructing efficiency-balanced binary block designs which are design patterns for simplification of statistical analysis. Furthermore, a method of construction of an efficiency-balanced block design with v+1 treatments from one with v treatments is generally characterized.     

Some extremal problems in designing discriminating experiments

This paper is devoted to some properties of local T-optimaj. designs fox discriminating between two rival regression models. It is demonstrated that the problem of searching for an optimal design is closely connected with the problem of searching for a Tchebycheff extremal basis. The question raised concerns the number of supporting points in an optimal design.     

On equivalence of fractional factorial designs based on singular value decomposition

The singular value decomposition of a real matrix always exists and is essentially unique. Based on the singular value decomposition of the design matrices of two general 2-level fractional factorial designs, new necessary and sufficient conditions for the determination of combinatorial equivalence or non-equivalence of the corresponding designs are derived. Equivalent fractional factorial designs have identical statistical properties for estimation of factorial contrasts and for model fitting. Non-equivalent designs, however, may have the same statistical properties under one particular model but different properties under a different model. Results extend to designs with factors at larger number of levels.     

Comparing and generating Latin Hypercube designs in Kriging models

In Computer Experiments (CE), a careful selection of the design points is essential for predicting the system response at untried points, based on the values observed at tried points. In physical experiments, the protocol is based on Design of Experiments, a methodology whose basic principles are questioned in CE. When the responses of a CE are modeled as jointly Gaussian random variables with their covariance depending on the distance between points, the use of the so called space-filling designs (random designs, stratified designs and Latin Hypercube designs) is a common choice, because it is expected that the nearer the untried point is to the design points, the better is the prediction. In this paper we focus on the class of Latin Hypercube (LH) designs. The behavior of various LH designs is examined according to the Gaussian assumption with exponential correlation, in order to minimize the total prediction error at the points of a regular lattice. In such a special case, the problem is reduced to an algebraic statistical model, which is solved using both symbolic algebraic software and statistical software. We provide closed-form computation of the variance of the Gaussian linear predictor as a function of the design, in order to make a comparison between LH designs. In principle, the method applies to any number of factors and any number of levels, and also to classes of designs other than LHs. In our current implementation, the applicability is limited by the high computational complexity of the algorithms involved.     

Computer-aided unbalanced supersaturated designs involving interactions

Supersaturated designs (SSDs) are defined as fractional factorial designs whose experimental run size is smaller than the number of main effects to be estimated. While most of the literature on SSDs has focused only on main effects designs, the construction and analysis of such designs involving interactions has not been developed to a great extent. In this paper, we propose a backward elimination design-driven optimization (BEDDO) method, with one main goal in mind, to eliminate the factors which are identified to be fully aliased or highly partially aliased with each other in the design. Under the proposed BEDDO method, we implement and combine correlation-based statistical measures taken from classical test theory and design of experiments field, and we also present an optimality criterion which is a modified form of Cronbach's alpha coefficient. In this way, we provide a new class of computer-aided unbalanced SSDs involving interactions, that derive directly from BEDDO optimization.     

On properties of efficiency-balanced designs

We consider a class of efficiency-balanced block designs which are design patterns for the analytical simplification of statistical analysis. This paper consists of eight sections which investigate various problems (such as, bounds on parameters, characterizations, existence and nonexistence, and dual designs) for efficiency-balanced block designs.     

Analysis of a supersaturated design using Entropy Prior Complexity for binary responses via generalized linear models

A supersaturated design is a factorial design in which the number of effects to be estimated is greater than the available number of experimental runs. It is used in many experiments for screening purposes, i.e., for studying a large number of factors and then identifying the active ones. The goal with such a design is to identify just a few of the factors under consideration, that have dominant effects and to do this at minimum cost. While most of the literature on supersaturated designs has focused on the construction of designs and their optimality, the data analysis of such designs remains still at an early stage. In this paper, we incorporate the parameter model complexity into the supersaturated design analysis process, by assuming generalized linear models for a Bernoulli response, for analyzing main effects designs and discovering simultaneously the effects that are significant.     

A clinical application of expert system methodology

In recent years, several expert systems have been developed for practical applications in applied statistical methodologies. Existing expert systems in statistics have explored several areas, e.g. the determination of appropriate statistical tests, regression analysis, and determination of the ‘best’ experimental design for industrial screening experiments. We present here the DESIGN EXPERT which is a prototype expert system for the design of complex statistical experiments. It is intended for scientific investigators and statisticians who must design and analyze complex experiments, e.g. multilevel medical experiments with nested factors, repeated measures, and both fixed and random eflects. This system is ‘expert’ in the sense that it is capable of the following:(i) recognize specific types of complex experimental designs, based on the application of inference rules to non-technical information supplied by the user; (ii) encode the obtained and inferred information in a flexible general-purpose internal representation, for use by other program modules; (iii) generate analysis of variance tables for the recognized design and an appropriate BMDP runfile for data analysis, using the encoded information. DESIGN EXPERT is capable of recognizing randomized block designs, including lattice designs within embedded Latin squares, cross-over designs, split plots, nesting, repeated measures and covariates. It is written in an experimental programming language developed specifically for research in artificial intelligence.     

Covariance Analysis for Split-Plot and Split-Block Designs

Commentaries are informative essays dealing with viewpoints of statistical practice, statistical education, and other topics considered to be of general interest to the broad readership of The American Statistician. Commentaries are similar in spirit to Letters to the Editor, but they involve longer discussions of background, issues, and perspectives. All commentaries will be refereed for their merit and compatibility with these criteria.

Proper methodology for the analysis of covariance for experiments designed in a split-plot or split-block design is not found in the statistical literature. Analyses for these designs are often performed incompletely or even incorrectly. This is especially true when popular statistical computer software packages are used for the analysis of these designs. This article provides several appropriate models, ANOVA tables, and standard errors for comparisons from experiments arranged in a standard split-plot, split–split-plot, or split-block design where a covariate has been measured on the smallest size experimental unit.     

Optimal statistical designs with circular string property

This paper develops an approximate theory for D- and A-optlmal statistical designs with a circular string property. It is shown how the problems of deriving optimal designs can be reduced to non-linear programming problems involving small numbers of decision variables. The results are seen to be helpful in dealing with the exact design problem with a finite number of obser vations.     

A note on all-bias designs with applications in spline regression models

If a model is fitted to empirical data, bias can arise from terms which are not incorporated in the model assumptions. As a consequence the commonly used optimality criteria based on the generalized variance of the estimator of the model parameters may not lead to efficient designs for the statistical analysis. In this note some general aspects of all-bias designs are presented, which were introduced in this context by Box and Draper (1959). Using an interesting correspondence between the points of all-bias designs and the knots of quadrature formulas we establish sufficient conditions such that a given design is an all-bias design. The results are illustrated in the special case of spline regression models. In particular our results generalize recent findings of Woods and Lewis (2006).     

Cost-cautious designs for confirmatory bioassay

Confirmatory bioassay experiments take place in late stages of the drug discovery process when a small number of compounds have to be compared with respect to their properties. As the cost of the observations may differ considerably, the design problem is well specified by the cost of compound used rather than by the number of observations. We show that cost-efficient designs can be constructed using useful properties of the minimum support designs. These designs are particularly suited for studies where the parameters of the model to be estimated are known with high accuracy prior to the experiment, although they prove to be robust against typical inaccuracies of these values. When the parameters of the model can only be specified with ranges of values or by a probability distribution, we use a Bayesian criterion of optimality to construct the required designs. Typically, the number of their support points depends on the prior knowledge for the model parameters. In all cases we recommend identifying a set of designs with good statistical properties but different potential costs to choose from.     

Design two-level factorial experiments in blocks of size four

Recently, many researchers have devoted themselves to the investigation on the number of replicates needed for experiments in blocks of size two. In practice, experiments in blocks of size four might be more useful than those in blocks of size two. To estimate the main effects and two-factor interactions from a two-level factorial experiment in blocks, we might need many replicates. This article investigates designs with the least number of replicates for factorial experiments in blocks of size four. The methods to obtain such designs are presented.     

The family of t-designs—part I

The family of t-designs is, without any doubt, the most important family of statistical designs. Their importance is due to their statistical optimalities, desirable symmetries for analyses and interpretations, and uses for constructing other important designs and structures such as Youden designs, generalized Youden designs, optimal fractional factorial designs, error defecting and correcting binary codes, balanced arrays, combinatorial filing systems, Hadamard matrices, finite projective and affine planes, strongly regular graphs, and so on. Research in the area of t-designs has been steadily and rapidly growing, especially during the last three decades. The number of publications in this area is in the several hundreds. Since papers on t-designs are published in a variety of journals, and because of the extensive role of these designs in design of experiments and other areas we believe it is imperative to gather these results and present them in varied form to suit diverse interests. This paper is an instance of such an attempt.     

A guide to the design and analysis of small clinical studies

Clinical studies, which have a small number of patients, are conducted by pharmaceutical companies and research institutions. Examples of constraints that lead to a small clinical study include a single investigative site with a highly specialized expertise or equipment, rare diseases, and limited time and budget. We consider the following topics, which we believe will be helpful for the investigator and statistician working together on the design and analysis of small clinical studies: definitions of various types of small studies (exploratory, pilot, proof of concept); bias and ways to mitigate the bias; commonly used study designs for randomized and nonrandomized studies, and some less commonly used designs; potential ethical issues associated with small underpowered clinical studies; sample size for small studies; statistical analysis methods for different types of variables and multiplicity issues. We conclude the paper with recommendations made by an Institute of Medicine committee, which was asked to assess the current methodologies and appropriate situations for conducting small clinical studies.     

Statistical Inference of Adaptive Designs with Binary Responses

Adaptive designs of clinical trials are ethical alternatives when the traditional randomization becomes ethically infeasible in desperate medical situations. However, such a design creates a dependency among trial data and its statistical analysis becomes more complex than the analysis for traditional randomized clinical trials. In this article, we examine adaptive designs with dichotomous responses from two treatments and extend some commonly used statistical methods for independent data. Under a regularity condition, the estimated odds ratio and its logarithm are shown to follow asymptotically normal distributions. Moreover, the ordinary goodness-of-fit test statistic for two-by-two contingency tables with dependent data is shown to be asymptotically chi-square distributed. We also discuss the consistency of maximum likelihood estimators of the unknown parameters for a wide class of adaptive designs.     

A relaxation procedure for calculating (G–)minimax optimal designs

Summary: In nonlinear statistical models, standard optimality functions for experimental designs depend on the unknown parameters of the model. An appealing and robust concept for choosing a design is the minimax criterion. However, so far, minimax optimal designs have been calculated efficiently under various restrictive conditions only. We extend an iterative relaxation scheme originally proposed by Shimizu and Aiyoshi (1980) and prove its convergence under very general assumptions which cover a variety of situations considered in experimental design. Application to different specific design criteria is discussed and issues of practical implementation are addressed. First numerical results suggest that the method may be very efficient with respect to the number of iterations required.*Supported by a grant from the Deutsche Forschungsgemeinschaft. We are grateful to a referee for his constructive suggestions.     

Selection and screening procedures to determine optimal product designs

To compare several promising product designs, manufacturers must measure their performance under multiple environmental conditions. In many applications, a product design is considered to be seriously flawed if its performance is poor for any level of the environmental factor. For example, if a particular automobile battery design does not function well under temperature extremes, then a manufacturer may not want to put this design into production. Thus, this paper considers the measure of a product's quality to be its worst performance over the levels of the environmental factor. We develop statistical procedures to identify (a near) optimal product design among a given set of product designs, i.e., the manufacturing design that maximizes the worst product performance over the levels of the environmental variable. We accomplish this by intuitive procedures based on the split-plot experimental design (and the randomized complete block design as a special case); split-plot designs have the essential structure of a product array and the practical convenience of local randomization. Two classes of statistical procedures are provided. In the first, the δ-best formulation of selection problems, we determine the number of replications of the basic split-plot design that are needed to guarantee, with a given confidence level, the selection of a product design whose minimum performance is within a specified amount, δ, of the performance of the optimal product design. In particular, if the difference between the quality of the best and second best manufacturing designs is δ or more, then the procedure guarantees that the best design will be selected with specified probability. For applications where a split-plot experiment that involves several product designs has been completed without the planning required of the δ-best formulation, we provide procedures to construct a ‘confidence subset’ of the manufacturing designs; the selected subset contains the optimal product design with a prespecified confidence level. The latter is called the subset selection formulation of selection problems. Examples are provided to illustrate the procedures.