A monte carlo investigation of a statistic for a bivariate missing data problem

Testing the equal means hypothesis of a bivariate normal distribution with homoscedastic varlates when the data are incomplete is considered. If the correlational parameter, ρ, is known, the well-known theory of the general linear model is easily employed to construct the likelihood ratio test for the two sided alternative. A statistic, T, for the case of ρ unknown is proposed by direct analogy to the likelihood ratio statistic when ρ is known. The null and nonnull distribution of T is investigated by Monte Carlo techniques. It is concluded that T may be compared to the conventional t distribution for testing the null hypothesis and that this procedure results in a substantial increase in power-efficiency over the procedure based on the paired t test which ignores the incomplete data. A Monte Carlo comparison to two statistics proposed by Lin and Stivers (1974) suggests that the test based on T is more conservative than either of their statistics.     

Review of Statistical Filmstrip Programs

We develop a novel nonparametric likelihood ratio test for independence between two random variables using a technique that is free of the common constraints of defining a given set of specific dependence structures. Our methodology revolves around an exact density-based empirical likelihood ratio test statistic that approximates in a distribution-free fashion the corresponding most powerful parametric likelihood ratio test. We demonstrate that the proposed test is very powerful in detecting general structures of dependence between two random variables, including nonlinear and/or random-effect dependence structures. An extensive Monte Carlo study confirms that the proposed test is superior to the classical nonparametric procedures across a variety of settings. The real-world applicability of the proposed test is illustrated using data from a study of biomarkers associated with myocardial infarction. Supplementary materials for this article are available online.     

Testing equality of mean vectors in a one-way MANOVA with monotone missing data

In this study, testing the equality of mean vectors in a one-way multivariate analysis of variance (MANOVA) is considered when each dataset has a monotone pattern of missing observations. The likelihood ratio test (LRT) statistic in a one-way MANOVA with monotone missing data is given. Furthermore, the modified test (MT) statistic based on likelihood ratio (LR) and the modified LRT (MLRT) statistic with monotone missing data are proposed using the decomposition of the LR and an asymptotic expansion for each decomposed LR. The accuracy of the approximation for the Chi-square distribution is investigated using a Monte Carlo simulation. Finally, an example is given to illustrate the methods.     

An exact density-based empirical likelihood ratio test for paired data

The Wilcoxon rank-sum test and its variants are historically well-known to be very powerful nonparametric decision rules for testing no location difference between two groups given paired data versus a shift alternative. In this title, we propose a new alternative empirical likelihood (EL) ratio approach for testing the equality of marginal distributions given that sampling is from a continuous bivariate population. We show that in various shift alternative scenarios the proposed exact test is superior to the classic nonparametric procedures, which may break down completely or are frequently inferior to the density-based EL ratio test. This is particularly true in the cases where there is a nonconstant shift under the alternative or the data distributions are skewed. An extensive Monte Carlo study shows that the proposed test has excellent operating characteristics. We apply the density-based EL ratio test to analyze real data from two medical studies.     

Bootstrap Bartlett correction in inflated beta regression

The inflated beta regression model aims to enable the modeling of responses in the intervals (0, 1], [0, 1), or [0, 1]. In this model, hypothesis testing is often performed based on the likelihood ratio statistic. The critical values are obtained from asymptotic approximations, which may lead to distortions of size in small samples. In this sense, this article proposes the bootstrap Bartlett correction to the statistic of likelihood ratio in the inflated beta regression model. The proposed adjustment only requires a simple Monte Carlo simulation. Through extensive Monte Carlo simulations the finite sample performance (size and power) of the proposed corrected test is compared to the usual likelihood ratio test and the Skovgaard adjustment already proposed in the literature. The numerical results evidence that inference based on the proposed correction is much more reliable than that based on the usual likelihood ratio statistics and the Skovgaard adjustment. At the end of the work, an application to real data is also presented.     

Comparison to control in logistic regression

We are interested in comparing logistic regressions for several test treatments or populations with a logistic regression for a standard treatment or population. The research was motivated by some real life problems, which are discussed as data examples. We propose a step-down likelihood ratio method for declaring differences between the test treatments or populations and the standard treatment or population. Competitors based on the sequentially rejective Bonferroni Wald statistic, sequentially rejective exact Wald statistic and Reiers?l's statistic are also discussed. It is shown that the proposed method asymptotically controls the probability of type I error. A Monte Carlo simulation shows that the proposed method performs well for relatively small sample sizes, outperforming its competitors.     

An empirical likelihood ratio based goodness-of-fit test for Inverse Gaussian distributions

The Inverse Gaussian (IG) distribution is commonly introduced to model and examine right skewed data having positive support. When applying the IG model, it is critical to develop efficient goodness-of-fit tests. In this article, we propose a new test statistic for examining the IG goodness-of-fit based on approximating parametric likelihood ratios. The parametric likelihood ratio methodology is well-known to provide powerful likelihood ratio tests. In the nonparametric context, the classical empirical likelihood (EL) ratio method is often applied in order to efficiently approximate properties of parametric likelihoods, using an approach based on substituting empirical distribution functions for their population counterparts. The optimal parametric likelihood ratio approach is however based on density functions. We develop and analyze the EL ratio approach based on densities in order to test the IG model fit. We show that the proposed test is an improvement over the entropy-based goodness-of-fit test for IG presented by Mudholkar and Tian (2002). Theoretical support is obtained by proving consistency of the new test and an asymptotic proposition regarding the null distribution of the proposed test statistic. Monte Carlo simulations confirm the powerful properties of the proposed method. Real data examples demonstrate the applicability of the density-based EL ratio goodness-of-fit test for an IG assumption in practice.     

On a test of independence for contingency tables

Using the concept of distributional distance, a test statistic is proposed FOR the hypothesis of independence in multidimensional contingency tables. A Monte Carlo Study is done to empirically compare the power of the proposed test to the Pearson x² and the likelihood ratio test- Further, the nonnull distribution under various spike alternatives is tabulated     

A test for the linearity of the nonparametric part of a semiparametric logistic regression model

A semiparametric logistic regression model is proposed in which its nonparametric component is approximated with fixed-knot cubic B-splines. To assess the linearity of the nonparametric component, we construct a penalized likelihood ratio test statistic. When the number of knots is fixed, the null distribution of the test statistic is shown to be asymptotically the distribution of a linear combination of independent chi-squared random variables, each with one degree of freedom. We set the asymptotic null expectation of this test statistic equal to a value to determine the smoothing parameter value. Monte Carlo experiments are conducted to investigate the performance of the proposed test. Its practical use is illustrated with a real-life example.     

Asymptotocally nonparametric tests with censored paired data

A class of asymptotically nonparametric test with contains a test proposed by Wei(1980), is considered for testing the equality of two continuous distribution funcitons when paired observations are subject to arbitrary right censorship. It is shown that under the null hypothesis each test statistic converges in distribution to the standard normal random variable. Furthermore. the Monte Carlo simulation results indicate that some tests in this class are more powerful than Wei's test. A generalization to incomplete censored paired data is also included.     

Improved likelihood inference in beta regression

We consider the issue of performing accurate small-sample likelihood-based inference in beta regression models, which are useful for modelling continuous proportions that are affected by independent variables. We derive small-sample adjustments to the likelihood ratio statistic in this class of models. The adjusted statistics can be easily implemented from standard statistical software. We present Monte Carlo simulations showing that inference based on the adjusted statistics we propose is much more reliable than that based on the usual likelihood ratio statistic. A real data example is presented.     

Likelihood ratio tests for testing for multiple contaminants in the shocks and labelled slippage models

In the literature related to the study of lifelengths of experimental units, little attention has been paid to the models where shocks to the units generate outliers. In the present article, we consider a situation where n experimental units under investigation receive shocks at several time points. The parameter values of the lifelength distribution may change due to each shock, resulting in the generation of outliers. We derive the likelihood ratio test statistic to investigate if the shocks have significantly altered the parameter values. We also derive a likelihood ratio test under the labelled slippage alternative with multiple contaminations. Monte Carlo studies have been carried out to investigate the power of the proposed test statistics.     

Gini index based goodness-of-fit test for the logistic distribution

To model growth curves in survival analysis and biological studies the logistic distribution has been widely used. In this article, we propose a goodness-of-fit test for the logistic distribution based on an estimate of the Gini index. The exact distribution of the proposed test statistic and also its asymptotic distribution are presented. In order to compute the proposed test statistic, parameters of the logistic distribution are estimated by approximate maximum likelihood estimators (AMLEs), which are simple explicit estimators. Through Monte Carlo simulations, power comparisons of the proposed test with some known competing tests are carried. Finally, an illustrative example is presented and analyzed.     

Testing equality of correlation coefficients for paired binary data from multiple groups

Paired binary data arise naturally when paired body parts are investigated in clinical trials. One of the widely used models for dealing with this kind of data is the equal correlation coefficients model. Before using this model, it is necessary to test whether the correlation coefficients in each group are actually equal. In this paper, three test statistics (likelihood ratio test, Wald-type test, and Score test) are derived for this purpose. The simulation results show that the Score test statistic maintains type I error rate and has satisfactory power, and therefore is recommended among the three methods. The likelihood ratio test is over conservative in most cases, and the Wald-type statistic is not robust with respect to empirical type I error. Three real examples, including a multi-centre Phase II double-blind placebo randomized controlled trial, are given to illustrate the three proposed test statistics.     

A likelihood ratio test of quasi-independence for sparse two-way contingency tables

We consider a likelihood ratio test of independence for large two-way contingency tables having both structural (non-random) and sampling (random) zeros in many cells. The solution of this problem is not available using standard likelihood ratio tests. One way to bypass this problem is to remove the structural zeroes from the table and implement a test on the remaining cells which incorporate the randomness in the sampling zeros; the resulting test is a test of quasi-independence of the two categorical variables. This test is based only on the positive counts in the contingency table and is valid when there is at least one sampling (random) zero. The proposed (likelihood ratio) test is an alternative to the commonly used ad hoc procedures of converting the zero cells to positive ones by adding a small constant. One practical advantage of our procedure is that there is no need to know if a zero cell is structural zero or a sampling zero. We model the positive counts using a truncated multinomial distribution. In fact, we have two truncated multinomial distributions; one for the null hypothesis of independence and the other for the unrestricted parameter space. We use Monte Carlo methods to obtain the maximum likelihood estimators of the parameters and also the p-value of our proposed test. To obtain the sampling distribution of the likelihood ratio test statistic, we use bootstrap methods. We discuss many examples, and also empirically compare the power function of the likelihood ratio test relative to those of some well-known test statistics.     

Likelihood‐based Inference with Missing Data Under Missing‐at‐Random

Likelihood‐based inference with missing data is challenging because the observed log likelihood is often an (intractable) integration over the missing data distribution, which also depends on the unknown parameter. Approximating the integral by Monte Carlo sampling does not necessarily lead to a valid likelihood over the entire parameter space because the Monte Carlo samples are generated from a distribution with a fixed parameter value. We consider approximating the observed log likelihood based on importance sampling. In the proposed method, the dependency of the integral on the parameter is properly reflected through fractional weights. We discuss constructing a confidence interval using the profile likelihood ratio test. A Newton–Raphson algorithm is employed to find the interval end points. Two limited simulation studies show the advantage of the Wilks inference over the Wald inference in terms of power, parameter space conformity and computational efficiency. A real data example on salamander mating shows that our method also works well with high‐dimensional missing data.     

On tests detecting difference in means and variances simultaneously under normality

In this paper, we propose several tests for detecting difference in means and variances simultaneously between two populations under normality. First of all, we propose a likelihood ratio test. Then we obtain an expression of the likelihood ratio statistic by a product of two functions of random quantities, which can be used to test the two individual partial hypotheses for differences in means and variances. With those individual partial tests, we propose a union-intersection test. Also we consider two optimal tests by combining the p-values of the two individual partial tests. For obtaining null distributions, we apply the permutation principle with the Monte Carlo approach. Then we compare efficiency among the proposed tests with well-known ones through a simulation study. Finally, we discuss some interesting features related to the simultaneous tests and resampling methods as concluding remarks.     

An EM type estimation procedure for the destructive exponentially weighted Poisson regression cure model under generalized gamma lifetime

In this paper, we assume the number of competing causes to follow an exponentially weighted Poisson distribution. By assuming the initial number of competing causes can undergo destruction and that the population of interest has a cure fraction, we develop the EM algorithm for the determination of the MLEs of the model parameters of such a general cure model. This model is more flexible than the promotion time cure model and also provides an interesting and realistic interpretation of the biological mechanism of the occurrence of an event of interest. Instead of assuming a particular parametric distribution for the lifetime, we assume the lifetime to belong to the wider class of generalized gamma distribution. This allows us to carry out a model discrimination to select a parsimonious lifetime distribution that provides the best fit to the data. Within the EM framework, a two-way profile likelihood approach is proposed to estimate the shape parameters. An extensive Monte Carlo simulation study is carried out to demonstrate the performance of the proposed estimation method. Model discrimination is carried out by means of the likelihood ratio test and information-based methods. Finally, a data on melanoma is analyzed for illustrative purpose.     

Conditional heteroscedasticity test for Poisson autoregressive model

In this article, the problem of interest is testing the conditional heteroscedasticity of Poisson autoregressive model. We construct a non parametric test statistic based on empirical likelihood method. The asymptotic distribution of the proposed statistic is derived and its finite-sample property is examined through Monte Carlo simulations. The simulation results show that the proposed method is good for practical use.     

A density-based empirical likelihood ratio goodness-of-fit test for the Rayleigh distribution and power comparison

The Rayleigh distribution has been used to model right skewed data. Rayleigh [On the resultant of a large number of vibrations of the some pitch and of arbitrary phase. Philos Mag. 1880;10:73–78] derived it from the amplitude of sound resulting from many important sources. In this paper, a new goodness-of-fit test for the Rayleigh distribution is proposed. This test is based on the empirical likelihood ratio methodology proposed by Vexler and Gurevich [Empirical likelihood ratios applied to goodness-of-fit tests based on sample entropy. Comput Stat Data Anal. 2010;54:531–545]. Consistency of the proposed test is derived. It is shown that the distribution of the proposed test does not depend on scale parameter. Critical values of the test statistic are computed, through a simulation study. A Monte Carlo study for the power of the proposed test is carried out under various alternatives. The performance of the test is compared with some well-known competing tests. Finally, an illustrative example is presented and analysed.