Robust nonparametrics in mixed-MANOCOVA models

In robust and nonparametric MANOVA models, the basic assumptions of independence, homoscedasticity and multinormality of the error components have been relaxed to a certain extent. In mixed-effects MANOVA models, the random effects components (due to concomitant variates) rest on the linearity of the regression function and some other distributional homogeneity conditions that may not hold universally, and avoidance of such regularity conditions generally introduce complications. Some of these difficulties are eliminated here through a conditional functional estimation approach, and in this setup, improved estimation of the fixed effects parameters is presented in a unified manner. Robustness and efficacy of these nonparametric procedures are appraised, and the picture is compared with their parametric as well as semiparametric counterparts.     

Iterative weighted estimation based on variance modelling in linear regression models

ABSTRACT

The estimation of variance function plays an extremely important role in statistical inference of the regression models. In this paper we propose a variance modelling method for constructing the variance structure via combining the exponential polynomial modelling method and the kernel smoothing technique. A simple estimation method for the parameters in heteroscedastic linear regression models is developed when the covariance matrix is unknown diagonal and the variance function is a positive function of the mean. The consistency and asymptotic normality of the resulting estimators are established under some mild assumptions. In particular, a simple version of bootstrap test is adapted to test misspecification of the variance function. Some Monte Carlo simulation studies are carried out to examine the finite sample performance of the proposed methods. Finally, the methodologies are illustrated by the ozone concentration dataset.     

Efficient Estimation of an Additive Quantile Regression Model

Abstract. In this paper, two non‐parametric estimators are proposed for estimating the components of an additive quantile regression model. The first estimator is a computationally convenient approach which can be viewed as a more viable alternative to existing kernel‐based approaches. The second estimator involves sequential fitting by univariate local polynomial quantile regressions for each additive component with the other additive components replaced by the corresponding estimates from the first estimator. The purpose of the extra local averaging is to reduce the variance of the first estimator. We show that the second estimator achieves oracle efficiency in the sense that each estimated additive component has the same variance as in the case when all other additive components were known. Asymptotic properties are derived for both estimators under dependent processes that are strictly stationary and absolutely regular. We also provide a demonstrative empirical application of additive quantile models to ambulance travel times.     

MODELING AND ESTIMATING VARIANCES IN REGRESSION

ABSTRACT

It is well known that ignoring heteroscedasticity in regression analysis adversely affects the efficiency of estimation and renders the usual procedure for constructing prediction intervals inappropriate. In some applications, such as off-line quality control, knowledge of the variance function is also of considerable interest in its own right. Thus the modeling of variance constitutes an important part of regression analysis. A common practice in modeling variance is to assume that a certain function of the variance can be closely approximated by a function of a known parametric form. The logarithm link function is often used even if it does not fit the observed variation satisfactorily, as other alternatives may yield negative estimated variances. In this paper we propose a rich class of link functions for more flexible variance modeling which alleviates the major difficulty of negative variances. We suggest also an alternative analysis for heteroscedastic regression models that exploits the principle of “separation” discussed in Box (Signal-to-Noise Ratios, Performance Criteria and Transformation. Technometrics 1988, 30, 1–31). The proposed method does not require any distributional assumptions once an appropriate link function for modeling variance has been chosen. Unlike the analysis in Box (Signal-to-Noise Ratios, Performance Criteria and Transformation. Technometrics 1988, 30, 1–31), the estimated variances and their associated asymptotic variances are found in the original metric (although a transformation has been applied to achieve separation in a different scale), making interpretation of results considerably easier.     

Stochastic volatility demand systems

We address the estimation of stochastic volatility demand systems. In particular, we relax the homoscedasticity assumption and instead assume that the covariance matrix of the errors of demand systems is time-varying. Since most economic and financial time series are nonlinear, we achieve superior modeling using parametric nonlinear demand systems in which the unconditional variance is constant but the conditional variance, like the conditional mean, is also a random variable depending on current and past information. We also prove an important practical result of invariance of the maximum likelihood estimator with respect to the choice of equation eliminated from a singular demand system. An empirical application is provided, using the BEKK specification to model the conditional covariance matrix of the errors of the basic translog demand system.     

On a new family of shifted logarithmic transformations

Most parametric statistical methods are based on a set of assumptions: normality, linearity and homoscedasticity. Transformation of a metric response is a popular method to meet these assumptions. In particular, transformation of the response of a linear model is a popular method when attempting to satisfy the Gaussian assumptions on the error components in the model. A particular problem with common transformations such as the logarithm or the Box–Cox family is that negative and zero data values cannot be transformed. This paper proposes a new transformation which allows negative and zero data values. The method for estimating the transformation parameter consider an objective criteria based on kurtosis and skewness for achieving normality. Use of the new transformation and the method for estimating the transformation parameter are illustrated with three data sets.     

SAVE: Robust or not?

Abstract

Sliced average variance estimation (SAVE) is one of the best methods for estimating central dimension-reduction subspace in semi parametric regression models when covariates are normal. In recent days SAVE is being used to analyze DNA microarray data especially in tumor classification but most important drawback is normality of covariates. In this article, the asymptotic behavior of estimates of CDR space under varying slice size is studied through simulation studies when covariates are non normal but follows linearity condition as well as when covariates slightly perturbed from normal distribution and we observed that serious error may occur under violation normality assumption.     

LASSO-type estimators for semiparametric nonlinear mixed-effects models estimation

Parametric nonlinear mixed effects models (NLMEs) are now widely used in biometrical studies, especially in pharmacokinetics research and HIV dynamics models, due to, among other aspects, the computational advances achieved during the last years. However, this kind of models may not be flexible enough for complex longitudinal data analysis. Semiparametric NLMEs (SNMMs) have been proposed as an extension of NLMEs. These models are a good compromise and retain nice features of both parametric and nonparametric models resulting in more flexible models than standard parametric NLMEs. However, SNMMs are complex models for which estimation still remains a challenge. Previous estimation procedures are based on a combination of log-likelihood approximation methods for parametric estimation and smoothing splines techniques for nonparametric estimation. In this work, we propose new estimation strategies in SNMMs. On the one hand, we use the Stochastic Approximation version of EM algorithm (SAEM) to obtain exact ML and REML estimates of the fixed effects and variance components. On the other hand, we propose a LASSO-type method to estimate the unknown nonlinear function. We derive oracle inequalities for this nonparametric estimator. We combine the two approaches in a general estimation procedure that we illustrate with simulations and through the analysis of a real data set of price evolution in on-line auctions.     

Minimax Rates for Estimating the Variance and its Derivatives in Non–Parametric Regression

In this paper the van Trees inequality is applied to obtain lower bounds for the quadratic risk of estimators for the variance function and its derivatives in non–parametric regression models. This approach yields a much simpler proof compared to previously applied methods for minimax rates. Furthermore, the informative properties of the van Trees inequality reveal why the optimal rates for estimating the variance are not affected by the smoothness of the signal g . A Fourier series estimator is constructed which achieves the optimal rates. Finally, a second–order correction is derived which suggests that the initial estimator of g must be undersmoothed for the estimation of the variance.     

Model Selection,Transformations and Variance Estimation in Nonlinear Regression

The results of analyzing experimental data using a parametric model may heavily depend on the chosen model for regression and variance functions, moreover also on a possibly underlying preliminary transformation of the variables. In this paper we propose and discuss a complex procedure which consists in a simultaneous selection of parametric regression and variance models from a relatively rich model class and of Box-Cox variable transformations by minimization of a cross-validation criterion. For this it is essential to introduce modifications of the standard cross-validation criterion adapted to each of the following objectives: 1. estimation of the unknown regression function, 2. prediction of future values of the response variable, 3. calibration or 4. estimation of some parameter with a certain meaning in the corresponding field of application. Our idea of a criterion oriented combination of procedures (which usually if applied, then in an independent or sequential way) is expected to lead to more accurate results. We show how the accuracy of the parameter estimators can be assessed by a “moment oriented bootstrap procedure", which is an essential modification of the “wild bootstrap” of Härdle and Mammen by use of more accurate variance estimates. This new procedure and its refinement by a bootstrap based pivot (“double bootstrap”) is also used for the construction of confidence, prediction and calibration intervals. Programs written in Splus which realize our strategy for nonlinear regression modelling and parameter estimation are described as well. The performance of the selected model is discussed, and the behaviour of the procedures is illustrated, e.g., by an application in radioimmunological assay.     

Estimation of partially linear single-index additive hazards model with current status data

In this paper, we introduce a partially linear single-index additive hazards model with current status data. Both the unknown link function of the single-index term and the cumulative baseline hazard function are approximated by B-splines under a monotonicity constraint on the latter. The sieve method is applied to estimate the nonparametric and parametric components simultaneously. We show that, when the nonparametric link function is an exact B-spline, the resultant estimator of regression parameter vector is asymptotically normal and achieves the semiparametric information bound and the rate of convergence of the estimator for the cumulative baseline hazard function is optimal. Simulation studies are presented to examine the finite sample performance of the proposed estimation method. For illustration, we apply the method to a clinical dataset with current status outcome.     

Estimating curves and derivatives with parametric penalized spline smoothing

Accurate estimation of an underlying function and its derivatives is one of the central problems in statistics. Parametric forms are often proposed based on the expert opinion or prior knowledge of the underlying function. However, these strict parametric assumptions may result in biased estimates when they are not completely accurate. Meanwhile, nonparametric smoothing methods, which do not impose any parametric form, are quite flexible. We propose a parametric penalized spline smoothing method, which has the same flexibility as the nonparametric smoothing methods. It also uses the prior knowledge of the underlying function by defining an additional penalty term using the distance of the fitted function to the assumed parametric function. Our simulation studies show that the parametric penalized spline smoothing method can obtain more accurate estimates of the function and its derivatives than the penalized spline smoothing method. The parametric penalized spline smoothing method is also demonstrated by estimating the human height function and its derivatives from the real data.     

Efficient estimation in partially linear single‐index models for longitudinal data

In this paper, we consider the estimation of both the parameters and the nonparametric link function in partially linear single‐index models for longitudinal data that may be unbalanced. In particular, a new three‐stage approach is proposed to estimate the nonparametric link function using marginal kernel regression and the parametric components with generalized estimating equations. The resulting estimators properly account for the within‐subject correlation. We show that the parameter estimators are asymptotically semiparametrically efficient. We also show that the asymptotic variance of the link function estimator is minimized when the working error covariance matrices are correctly specified. The new estimators are more efficient than estimators in the existing literature. These asymptotic results are obtained without assuming normality. The finite‐sample performance of the proposed method is demonstrated by simulation studies. In addition, two real‐data examples are analyzed to illustrate the methodology.     

Optimum percentile estimating equations for nonlinear random coefficient models

In nonlinear random coefficients models, the means or variances of response variables may not exist. In such cases, commonly used estimation procedures, e.g., (extended) least-squares (LS) and quasi-likelihood methods, are not applicable. This article solves this problem by proposing an estimate based on percentile estimating equations (PEE). This method does not require full distribution assumptions and leads to efficient estimates within the class of unbiased estimating equations. By minimizing the asymptotic variance of the PEE estimates, the optimum percentile estimating equations (OPEE) are derived. Several examples including Weibull regression show the flexibility of the PEE estimates. Under certain regularity conditions, the PEE estimates are shown to be strongly consistent and asymptotic normal, and the OPEE estimates have the minimal asymptotic variance. Compared with the parametric maximum likelihood estimates (MLE), the asymptotic efficiency of the OPEE estimates is more than 98%, while the LS-type of procedures can have infinite variances. When the observations have outliers or do not follow the distributions considered in model assumptions, the article shows that OPEE is more robust than the MLE, and the asymptotic efficiency in the model misspecification cases can be above 150%.     

Random rounded integer-valued autoregressive conditional heteroskedastic process

The statistical literature on the analysis of discrete variate time series has concentrated mainly on parametric models, that is the conditional probability mass function is assumed to belong to a parametric family. Generally, these parametric models impose strong assumptions on the relationship between the conditional mean and variance. To generalize these implausible assumptions, this paper instead considers a more realistic semiparametric model, called random rounded integer-valued autoregressive conditional heteroskedastic (RRINARCH) model, where there are essentially no assumptions on the relationship between the conditional mean and variance. The new model has several advantages: (a) it provides a coherent semiparametric framework for discrete variate time series, in which the conditional mean and variance can be modeled separately; (b) it allows negative values both for the series and its autocorrelation function; (c) its autocorrelation structure is the same as that of a standard autoregressive (AR) process; (d) standard software for its estimation is directly applicable. For the new model, conditions for stationarity, ergodicity and the existence of moments are established and the consistency and asymptotic normality of the conditional least squares estimator are proved. Simulation experiments are carried out to assess the performance of the model. The analyses of real data sets illustrate the flexibility and usefulness of the RRINARCH model for obtaining more realistic forecast means and variances.     

On the pointwise mean squared error of a multidimensional term-by-term thresholding wavelet estimator

In this paper we provide a theoretical contribution to the pointwise mean squared error of an adaptive multidimensional term-by-term thresholding wavelet estimator. A general result exhibiting fast rates of convergence under mild assumptions on the model is proved. It can be applied for a wide range of non parametric models including possible dependent observations. We give applications of this result for the non parametric regression function estimation problem (with random design) and the conditional density estimation problem.     

Efficient sequential estimation for compound poisson processes

This paper discusses uniformly minimum variance, unbiased sequential estimation of a real-valued parametric function for a compound Poisson process when the compounding random variables belong to the exponential family. The characterization of Cramer-Rao efficient plans by Stefanov (1982 b) is shown to be incomplete by obtaining a new efficient plan for the compound Poisson-Bernoulli process. This new plan completes the characterization of Cramer-Rao efficient plans. The class of Bhattacharyya efficient estimators of order two is determined for all the efficient sampling schemes.     

Testing of homogeneity of variance and autocorrelation coefficients of nonlinear mixed models with AR(1) errors based on M-estimation

Homogeneity of between-individual variance and autocorrelation coefficients is one of assumptions in the study of longitudinal data. However, the assumption could be challenging due to the complexity of the dataset. In the paper we propose and analyze nonlinear mixed models with AR(1) errors for longitudinal data, intend to introduce Huber's function in the log-likelihood function and get robust estimation, which may help to reduce the influence of outliers, by Fisher scoring method. Testing of homogeneity of variance among individuals and autocorrelation coefficients on the basis of Huber's M-estimation is studied later in the paper. Simulation studies are carried to assess performance of score test we proposed. Results obtained from plasma concentrations data are reported as an illustrative example.     

Generalised quasi‐likelihood inference in a semi‐parametric binary dynamic mixed logit model

There exists a recent study where dynamic mixed‐effects regression models for count data have been extended to a semi‐parametric context. However, when one deals with other discrete data such as binary responses, the results based on count data models are not directly applicable. In this paper, we therefore begin with existing binary dynamic mixed models and generalise them to the semi‐parametric context. For inference, we use a new semi‐parametric conditional quasi‐likelihood (SCQL) approach for the estimation of the non‐parametric function involved in the semi‐parametric model, and a semi‐parametric generalised quasi‐likelihood (SGQL) approach for the estimation of the main regression, dynamic dependence and random effects variance parameters. A semi‐parametric maximum likelihood (SML) approach is also used as a comparison to the SGQL approach. The properties of the estimators are examined both asymptotically and empirically. More specifically, the consistency of the estimators is established and finite sample performances of the estimators are examined through an intensive simulation study.     

Tail density estimation for exploratory data analysis using kernel methods

It is often critical to accurately model the upper tail behaviour of a random process. Nonparametric density estimation methods are commonly implemented as exploratory data analysis techniques for this purpose and can avoid model specification biases implied by using parametric estimators. In particular, kernel-based estimators place minimal assumptions on the data, and provide improved visualisation over scatterplots and histograms. However kernel density estimators can perform poorly when estimating tail behaviour above a threshold, and can over-emphasise bumps in the density for heavy tailed data. We develop a transformation kernel density estimator which is able to handle heavy tailed and bounded data, and is robust to threshold choice. We derive closed form expressions for its asymptotic bias and variance, which demonstrate its good performance in the tail region. Finite sample performance is illustrated in numerical studies, and in an expanded analysis of the performance of global climate models.