The IPW estimator for the joint distribution function of the gap times from recurrent event data

Lee et al. in 2016 proposed a nonparametric estimator of the joint distribution of the gap time between transplant and the first infection and the following gap times between consecutive infections. In this article, we propose an alternative estimator based on the inverse-probability weighted (IPW) approach. Asymptotic properties of the proposed estimator are established . Simulation results indicate that the IPW estimator performs as well as the estimator proposed by Lee et al. We also propose an IPW estimator for estimating the joint distribution function of the gap times between consecutive recurrent events beyond the first episode.     

Some unbiased estimators versus mean per unit and ratio estimators in finite population sample surveys

We present some unbiased estimators at the population mean in a finite population sample surveys with simple random sampling design where information on an auxiliary variance x positively correlated with the main variate y is available. Exact variance and unbiased estimate of the variance are computed for any sample size. These estimators are compared for their precision with the mean per unit and the ratio estimators. Modifications of the estimators are suggested to make them more precise than the mean per unit estimator or the ratio estimator regardless of the value of the population correlation coefficient between the variates x and y. Asymptotic distribution of our estimators and confidnece intervals for the population mean are also obtained.     

Non parametric analysis of gap times for bivariate recurrent event data with cure fraction

Recurrent event data often arise in longitudinal studies. In many applications, subjects may experience two different types of events alternatively over time or a pair of subjects may experience recurrent events of the same type. Medical advances have made it possible for some patients to be cured such that the disease of interest does not recur. In this article, we consider non parametric analysis of bivariate recurrent event data with cure fraction. Using the inverse-probability weighted (IPW) approach, we propose non parametric estimators for the proportion of cured patients and for the joint distribution functions of bivariate recurrence times of the uncured ones. The asymptotic properties of the proposed estimators are established. Simulation study indicates that the proposed estimators perform well in finite samples.     

Nonparametric estimators for a survivor function of paired recurrent events

Recurrent event data arise in longitudinal studies where each study subject may experience multiple events during the follow-up. In many situations in survival studies, pairs of individuals can potentially experience recurrent events. The analysis of such data is not straightforward as it involves two kinds of dependences, namely, dependence between the individuals in the same pair and dependence among a sequence of pairs. In the present paper, we introduce a new stochastic model for the analysis of such recurrent event data. Nonparametric estimators for a bivariate survivor function are developed. Asymptotic properties of the estimators are discussed. Simulation studies are carried out to assess the finite sample properties of the estimator. We illustrate the procedure with real life data on eye disease.     

Semiparametric proportional means model for marker data contingent on recurrent event

In many biomedical studies with recurrent events, some markers can only be measured when events happen. For example, medical cost attributed to hospitalization can only incur when patients are hospitalized. Such marker data are contingent on recurrent events. In this paper, we present a proportional means model for modelling the markers using the observed covariates contingent on the recurrent event. We also model the recurrent event via a marginal rate model. Estimating equations are constructed to derive the point estimators for the parameters in the proposed models. The estimators are shown to be asymptotically normal. Simulation studies are conducted to examine the finite-sample properties of the proposed estimators and the proposed method is applied to a data set from the Vitamin A Community Trial.     

Nonparametric Bayes estimation of gap-time distribution with recurrent event data

Nonparametric Bayes (NPB) estimation of the gap-time survivor function governing the time to occurrence of a recurrent event in the presence of censoring is considered. In our Bayesian approach, the gap-time distribution, denoted by F, has a Dirichlet process prior with parameter α. We derive NPB and nonparametric empirical Bayes (NPEB) estimators of the survivor function F?=1?F and construct point-wise credible intervals. The resulting Bayes estimator of F? extends that based on single-event right-censored data, and the PL-type estimator is a limiting case of this Bayes estimator. Through simulation studies, we demonstrate that the PL-type estimator has smaller biases but higher root-mean-squared errors (RMSEs) than those of the NPB and the NPEB estimators. Even in the case of a mis-specified prior measure parameter α, the NPB and the NPEB estimators have smaller RMSEs than the PL-type estimator, indicating robustness of the NPB and NPEB estimators. In addition, the NPB and NPEB estimators are smoother (in some sense) than the PL-type estimator.     

Modeling marginal features in studies of recurrent events in the presence of a terminal event

We study models for recurrent events with special emphasis on the situation where a terminal event acts as a competing risk for the recurrent events process and where there may be gaps between periods during which subjects are at risk for the recurrent event. We focus on marginal analysis of the expected number of events and show that an Aalen–Johansen type estimator proposed by Cook and Lawless is applicable in this situation. A motivating example deals with psychiatric hospital admissions where we supplement with analyses of the marginal distribution of time to the competing event and the marginal distribution of the time spent in hospital. Pseudo-observations are used for the latter purpose.

     

Partially Calibrated Poststratified Weights for Handling Unit Non Response

We consider a non response-adjusted poststratified estimation when there exists a set of clear response homogeneity groups but the population distribution of that set is unknown, which is common in practice. We propose a partially calibrated poststratified estimator that is asymptotically unbiased and satisfies a calibration equation for the auxiliary variables of which the joint population distribution is known. We also provide a variance estimator of the proposed poststratified estimator. In a small simulation study, the proposed estimator performed better than or comparable to commonly used estimators.     

A class of additive transformation models for recurrent gap times

Abstract

The gap time between recurrent events is often of primary interest in many fields such as medical studies, and in this article, we discuss regression analysis of the gap times arising from a general class of additive transformation models. For the problem, we propose two estimation procedures, the modified within-cluster resampling (MWCR) method and the weighted risk-set (WRS) method, and the proposed estimators are shown to be consistent and asymptotically follow the normal distribution. In particular, the estimators have closed forms and can be easily determined, and the methods have the advantage of leaving the correlation among gap times arbitrary. A simulation study is conducted for assessing the finite sample performance of the presented methods and suggests that they work well in practical situations. Also the methods are applied to a set of real data from a chronic granulomatous disease (CGD) clinical trial.     

The analysis of multivariate recurrent events with partially missing event types

In many clinical studies, subjects are at risk of experiencing more than one type of potentially recurrent event. In some situations, however, the occurrence of an event is observed, but the specific type is not determined. We consider the analysis of this type of incomplete data when the objectives are to summarize features of conditional intensity functions and associated treatment effects, and to study the association between different types of event. Here we describe a likelihood approach based on joint models for the multi-type recurrent events where parameter estimation is obtained from a Monte-Carlo EM algorithm. Simulation studies show that the proposed method gives unbiased estimators for regression coefficients and variance–covariance parameters, and the coverage probabilities of confidence intervals for regression coefficients are close to the nominal level. When the distribution of the frailty variable is misspecified, the method still provides estimators of the regression coefficients with good properties. The proposed method is applied to a motivating data set from an asthma study in which exacerbations were to be sub-typed by cellular analysis of sputum samples as eosinophilic or non-eosinophilic.     

Bias-corrected realized variance

We propose a novel “bias-corrected realized variance” (BCRV) estimator based upon the appropriate re-weighting of two realized variances calculated at different sampling frequencies. Our bias-correction methodology is found to be extremely accurate, with the finite sample variance being significantly minimized. In our Monte Carlo experiments and a finite sample MSE comparison of alternative estimators, the performance of our straightforward BCRV estimator is shown to be comparable to other widely-used integrated variance estimators. Given its simplicity, our BCRV estimator is likely to appeal to researchers and practitioners alike for the estimation of integrated variance.     

A method of moments estimator of tail dependence in meta-elliptical models

A meta-elliptical model is a distribution function whose copula is that of an elliptical distribution. The tail dependence function in such a bivariate model has a parametric representation with two parameters: a tail parameter and a correlation parameter. The correlation parameter can be estimated by robust methods based on the whole sample. Using the estimated correlation parameter as plug-in estimator, we then estimate the tail parameter applying a modification of the method of moments approach proposed in the paper by Einmahl et al. (2008). We show that such an estimator is consistent and asymptotically normal. Further, we derive the joint limit distribution of the estimators of the two parameters. We illustrate the small sample behavior of the estimator of the tail parameter by a simulation study and on real data, and we compare its performance to that of the competitive estimators.     

A joint modelling approach for clustered recurrent events and death events

In dental implant research studies, events such as implant complications including pain or infection may be observed recurrently before failure events, i.e. the death of implants. It is natural to assume that recurrent events and failure events are correlated to each other, since they happen on the same implant (subject) and complication times have strong effects on the implant survival time. On the other hand, each patient may have more than one implant. Therefore these recurrent events or failure events are clustered since implant complication times or failure times within the same patient (cluster) are likely to be correlated. The overall implant survival times and recurrent complication times are both interesting to us. In this paper, a joint modelling approach is proposed for modelling complication events and dental implant survival times simultaneously. The proposed method uses a frailty process to model the correlation within cluster and the correlation within subjects. We use Bayesian methods to obtain estimates of the parameters. Performance of the joint models are shown via simulation studies and data analysis.     

Variance estimation of the Buckley–James estimator under discrete assumptions

The Buckley–James estimator (BJE) is a widely recognized approach in dealing with right-censored linear regression models. There have been a lot of discussions in the literature on the estimation of the BJE as well as its asymptotic distribution. So far, no simulation has been done to directly estimate the asymptotic variance of the BJE. Kong and Yu [Asymptotic distributions of the Buckley–James estimator under nonstandard conditions, Statist. Sinica 17 (2007), pp. 341–360] studied the asymptotic distribution under discontinuous assumptions. Based on their methodology, we recalculate and correct some missing terms in the expression of the asymptotic variance in Theorem 2 of their work. We propose an estimator of the standard deviation of the BJE by using plug-in estimators. The estimator is shown to be consistent. The performance of the estimator is accessed through simulation studies under discrete underline distributions. We further extend our studies to several continuous underline distributions through simulation. The estimator is also applied to a real medical data set. The simulation results suggest that our estimation is a good approximation to the true standard deviation with reference to the empirical standard deviation.     

Additive–multiplicative rates model for recurrent events

Recurrent events are frequently encountered in biomedical studies. Evaluating the covariates effects on the marginal recurrent event rate is of practical interest. There are mainly two types of rate models for the recurrent event data: the multiplicative rates model and the additive rates model. We consider a more flexible additive–multiplicative rates model for analysis of recurrent event data, wherein some covariate effects are additive while others are multiplicative. We formulate estimating equations for estimating the regression parameters. The estimators for these regression parameters are shown to be consistent and asymptotically normally distributed under appropriate regularity conditions. Moreover, the estimator of the baseline mean function is proposed and its large sample properties are investigated. We also conduct simulation studies to evaluate the finite sample behavior of the proposed estimators. A medical study of patients with cystic fibrosis suffered from recurrent pulmonary exacerbations is provided for illustration of the proposed method.     

On intra-class correlation coefficient estimation

Consider the problem of estimating the intra-class correlation coefficient of a symmetric normal distribution. In a recent article (Pal and Lim (1999)) it has been shown that the three popular estimators, namely—the maximum likelihood estimator (MLE), the method of moments estimator (MME) and the unique minimum variance unbiased estimator (UMVUE), are second order admissible under the squared error loss function. In this paper we study the performance of the above mentioned estimators in terms of Pitman Nearness Criterion (PNC) as well as Stochastic Domination Criterion (SDC). We then apply the aforementioned estimators to two real life data sets with moderate to large sample sizes, and bootstrap bias as well as mean squared errors are computed to compare the estimators. In terms of overall performance the MME seems most appealing among the three estimators considered here and this is the main contribution of our paper. Formerly University of Southewestern Louisisna     

Bernstein conditional density estimation with application to conditional distribution and regression functions

In this paper we propose a smooth nonparametric estimation for the conditional probability density function based on a Bernstein polynomial representation. Our estimator can be written as a finite mixture of beta densities with data-driven weights. Using the Bernstein estimator of the conditional density function, we derive new estimators for the distribution function and conditional mean. We establish the asymptotic properties of the proposed estimators, by proving their asymptotic normality and by providing their asymptotic bias and variance. Simulation results suggest that the proposed estimators can outperform the Nadaraya–Watson estimator and, in some specific setups, the local linear kernel estimators. Finally, we use our estimators for modeling the income in Italy, conditional on year from 1951 to 1998, and have another look at the well known Old Faithful Geyser data.     

An empirical investigation of different operating characteristics of several estimators of the intraclass correlation in the analysis of binary data

This paper is concerned with properties (bias, standard deviation, mean square error and efficiency) of twenty six estimators of the intraclass correlation in the analysis of binary data. Our main interest is to study these properties when data are generated from different distributions. For data generation we considered three over-dispersed binomial distributions, namely, the beta-binomial distribution, the probit normal binomial distribution and a mixture of two binomial distributions. The findings regarding bias, standard deviation and mean squared error of all these estimators, are that (a) in general, the distributions of biases of most of the estimators are negatively skewed. The biases are smallest when data are generated from the beta-binomial distribution and largest when data are generated from the mixture distribution; (b) the standard deviations are smallest when data are generated from the beta-binomial distribution; and (c) the mean squared errors are smallest when data are generated from the beta-binomial distribution and largest when data are generated from the mixture distribution. Of the 26, nine estimators including the maximum likelihood estimator, an estimator based on the optimal quadratic estimating equations of Crowder (1987), and an analysis of variance type estimator is found to have least amount of bias, standard deviation and mean squared error. Also, the distributions of the bias, standard deviation and mean squared error for each of these estimators are, in general, more symmetric than those of the other estimators. Our findings regarding efficiency are that the estimator based on the optimal quadratic estimating equations has consistently high efficiency and least variability in the efficiency results. In the important range in which the intraclass correlation is small (≤0 5), on the average, this estimator shows best efficiency performance. The analysis of variance type estimator seems to do well for larger values of the intraclass correlation. In general, the estimator based on the optimal quadratic estimating equations seems to show best efficiency performance for data from the beta-binomial distribution and the probit normal binomial distribution, and the analysis of variance type estimator seems to do well for data from the mixture distribution.     

Nonparametric Survival Estimation when Death is Reported with Delay

In disease registries there can be a delay between death of asubject and the reporting of this death to the data analyst.If researchers use the Kaplan-Meier estimator and implicitlyassumed that subjects who have yet to have death reported arestill alive, i.e. are censored at the time of analysis, the Kaplan-Meierestimator is typically inconsistent. Assuming censoring is independentof failure, we provide a simple estimator that is consistentand asymptotically efficient. We also provide estimates of theasymptotic variance of our estimator and simulations that demonstratethe favorable performance of these estimators. Finally, we demonstrateour methods by analyzing AIDS survival data. This analysis underscoresthe pitfalls of not accounting for delay when estimating thesurvival distribution and suggests a significant reduction inbias by using our estimator.     

Variance estimation of DEE and regression estimator when a first-phase cluster sample is restratified

We consider a variance estimation when a stratified single stage cluster sample is selected in the first phase and a stratified simple random element sample is selected in the second phase. We propose explicit formulas of (asymptotically), we propose explicit formulas of (asymptotically) unbiased variance estimators for the double expansion estimator and regression estimator. We perform a small simulation study to investigate the performance of the proposed variance estimators. In our simulation study, the proposed variance estimator showed better or comparable performance to the Jackknife variance estimator. We also extend the results to a two-phase sampling design in which a stratified pps with replacement cluster sample is selected in the first phase.