A power transformation regression model for censored failure time data

A power transformation regression model is considered for exponentially distributed time to failure data with right censoring. Procedures for estimation of parameters by maximum likelihood and assessment of goodness of model fit are described and illustrated.     

Monte carlo results for conditional survival tests under randomly censored data

Within a Monte Carlo study finite sample results are obtained for different generalized rank tests based on randomly censored life time data. It is pointed out that conditional tests should be applied in practice whenever drastic differences between the censoring distributions for the underlying groups do not appear. The tests are slight modifications of known permutation tests for censored data.     

A regression method for censored inverse-Gaussian data

Multiple regression methods are considered for progressively right-censored inverse-Gaussian data. Maximum-likelihood estimators are derived using the EM algorithm, and their asymptotic distributional properties are presented. The methodology is demonstrated using two case illustrations, one of which involves the defective feature of the inverse-Gaussian distribution. The relationship of the methodology to regression methods for complete inverse-Gaussian samples and to other regression methods for censored survival data is discussed.     

A survey of permutation tests for censored survival data

The present paper surveys tests with censored sur-vival data for 2-and k-samples and for association by a framework which classifies them into complete or restric-ted permutation tests and into tests based on U-or Savage-scores. The formulae of the resulting twelve tests are briefly described for quick reference. Some of the tests have been applied frequently in the past as the tests by Mantel, Breslow or Gehan; others have been developed rather recently, partly by the author. The concluding discussion presents the results of a simulation study, clarifying similarities and differences of the restricted and complete permutation approach, and deals with rela-tive efficiencies of the two scoring systems.     

Almost most powerful tests against composite alternatives

Likelihood ratio considerations are used to derive uniform bounds on the acceptance and rejection regions of the family of locally most powerful randomization tests for a two-sample comparison of censored data, When applied to radioimmunoassay data, these bounds are close enough to permit effective decision making. The methodology extends to a wide class of testing problems.     

A semiparametric shock model for a pair of event-related dependent censored failure times

In this paper, we propose a semiparametric shock model for two dependent failure times where the risk indicator of one failure time plays the part of a time-varying covariate for the other one. According to Hougaard [2000. Analysis of Multivariate Survival Data. Springer, New York], the dependence between the two failure times is therefore of event-related type.     

The log-exponentiated generalized gamma regression model for censored data

For the first time, we introduce a generalized form of the exponentiated generalized gamma distribution [Cordeiro et al. The exponentiated generalized gamma distribution with application to lifetime data, J. Statist. Comput. Simul. 81 (2011), pp. 827–842.] that is the baseline for the log-exponentiated generalized gamma regression model. The new distribution can accommodate increasing, decreasing, bathtub- and unimodal-shaped hazard functions. A second advantage is that it includes classical distributions reported in the lifetime literature as special cases. We obtain explicit expressions for the moments of the baseline distribution of the new regression model. The proposed model can be applied to censored data since it includes as sub-models several widely known regression models. It therefore can be used more effectively in the analysis of survival data. We obtain maximum likelihood estimates for the model parameters by considering censored data. We show that our extended regression model is very useful by means of two applications to real data.     

A generalized Fleming and Harrington's class of tests for interval‐censored data

The class $G^{\rho,\lambda }$ of weighted log‐rank tests proposed by Fleming & Harrington [Fleming & Harrington (1991) Counting Processes and Survival Analysis, Wiley, New York] has been widely used in survival analysis and is nowadays, unquestionably, the established method to compare, nonparametrically, k different survival functions based on right‐censored survival data. This paper extends the $G^{\rho,\lambda }$ class to interval‐censored data. First we introduce a new general class of rank based tests, then we show the analogy to the above proposal of Fleming & Harrington. The asymptotic behaviour of the proposed tests is derived using an observed Fisher information approach and a permutation approach. Aiming to make this family of tests interpretable and useful for practitioners, we explain how to interpret different choices of weights and we apply it to data from a cohort of intravenous drug users at risk for HIV infection. The Canadian Journal of Statistics 40: 501–516; 2012 © 2012 Statistical Society of Canada     

Goodness-of-fit tests for parametric models in censored regression

The authors propose a goodness-of-fit test for parametric regression models when the response variable is right-censored. Their test compares an estimation of the error distribution based on parametric residuals to another estimation relying on nonparametric residuals. They call on a bootstrap mechanism in order to approximate the critical values of tests based on Kolmogorov-Smirnov and Cramér-von Mises type statistics. They also present the results of Monte Carlo simulations and use data from a study about quasars to illustrate their work.     

Nonparametric density estimation for censored survival data: Regression-spline approach

A method for nonparametric estimation of density based on a randomly censored sample is presented. The density is expressed as a linear combination of cubic M -splines, and the coefficients are determined by pseudo-maximum-likelihood estimation (likelihood is maximized conditionally on data-dependent knots). By using regression splines (small number of knots) it is possible to reduce the estimation problem to a space of low dimension while preserving flexibility, thus striking a compromise between parametric approaches and ordinary nonparametric approaches based on spline smoothing. The number of knots is determined by the minimum AIC. Examples of simulated and real data are presented. Asymptotic theory and the bootstrap indicate that the precision and the accuracy of the estimates are satisfactory.     

Analyzing type II censored data obtained from repetitious experiments

Experimental design and Taguchi's parameter design are widely employed by industry to optimize the process/product. However, censored data are often observed in product lifetime testing during the experiments. After implementing a repetitious experiment with type II censored data, the censored data are usually estimated by establishing a complex statistical model. However, using the incomplete data to fit a model may not accurately estimates the censored data. Moreover, the model fitting process is complicated for a practitioner who has only limited statistical training. This study proposes a less complex approach to analyze censored data, using the least square estimation method and Torres's analysis of unreplicated factorials with possible abnormalities. This study also presents an effective method to analyze the censored data from Taguchi's parameter design using least square estimation method. Finally, examples are given to illustrate the effectiveness of the proposed methods.     

Isotontic regression for interval censored survival data using an e-m algorithm

This paper develops a nonparametric model of the relationship between survival S and a dichotomous random variable X under the order constraint that P(X=1|S=s) is increasing (or decreasing) with s. The estimation procedure, called isotonic regression, has been studied in some depth for the case of uncensored data, but we give a methodology which is appropriate in the more general context of right, left, and interval censored data. An E-M Algorithm (Dempster et. al., 1977) is used for maximum likelihood estimation.     

Conditional Studentized Survival Tests for Randomly Censored Models

It is shown that in the case of heterogenous censoring distributions Studentized survival tests can be carried out as conditional permutation tests given the order statistics and their censoring status. The result is based on a conditional central limit theorem for permutation statistics. It holds for linear test statistics as well as for sup-statistics. The procedure works under one of the following general circumstances for the two-sample problem: the unbalanced sample size case, highly censored data, certain non-convergent weight functions or under alternatives. For instance, the two-sample log rank test can be carried out asymptotically as a conditional test if the relative amount of uncensored observations vanishes asymptotically as long as the number of uncensored observations becomes infinite. Similar results hold whenever the sample sizes and are unbalanced in the sense that and hold.     

Locally most powerful tests for the two sample problem when the combined sample is type ii censored

We derive locally most powerful tests for the two sample problem when the combined sample is type II censored. Both middle-censored and doubly-censored cases are considered. These include, in particular, the left- and right-censored cases. The main contribution of this paper is to provide extensive small sample size tables of critical values for Wilcoxon. normal scores, Freund-Ansari-Bradley and Capon tests.     

Quantile regression for interval censored data

As direct generalization of the quantile regression for complete observed data, an estimation method for quantile regression models with interval censored data is proposed, and the property of consistency is obtained. The property of asymptotic normality is also established with a bias converging to zero, and to reduce the bias, two bias correction methods are proposed. Methods proposed in this paper do not require the censoring vectors to be identically distributed, and can be applied to models with various covariates. Simulation results show that the proposed methods work well.     

Simple nonparametric tests for a known standard survival based on censored data

It is often of interest in survival analysis to test whether the distribution of lifetimes from which the sample under study was derived is the same as a reference distribution. The latter can be specified on the basis of previous studies or on subject matter considerations. In this paper several tests are developed for the above hypothesis, suitable for right-censored observations. The tests are based on modifications of Moses' one-sample limits of some classical two-sample rank tests. The asymptotic distributions of the test statistics are derived, consistency is established for alternatives which are stochastically ordered with respect to the null, and Pitman asymptotic efficiencies are calculated relative to competing tests. Simulated power comparisons are reported. An example is given with data on the survival times of lung cancer patients.     

On goodness of fit tests based on spacings for type ii censored samples

A class of tests based on spacings is obtained for milticensored samples. Their asymptotic null as well as alternative distributions are obtained.     

Tree-structured subgroup analysis for censored survival data: Validation of computationally inexpensive model selection criteria

The performance of computationally inexpensive model selection criteria in the context of tree-structured subgroup analysis is investigated. It is shown through simulation that no single model selection criterion exhibits a uniformly superior performance over a wide range of scenarios. Therefore, a two-stage approach for model selection is proposed and shown to perform satisfactorily. Applied example of subgroup analysis is presented. Problems associated with tree-structured subgroup analysis are discussed and practical solutions are suggested.     

A log-linear regression model for the odd Weibull distribution with censored data

We introduce the log-odd Weibull regression model based on the odd Weibull distribution (Cooray, 2006). We derive some mathematical properties of the log-transformed distribution. The new regression model represents a parametric family of models that includes as sub-models some widely known regression models that can be applied to censored survival data. We employ a frequentist analysis and a parametric bootstrap for the parameters of the proposed model. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to assess global influence. Further, for different parameter settings, sample sizes and censoring percentages, some simulations are performed. In addition, the empirical distribution of some modified residuals are given and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the proposed regression model applied to censored data. We define martingale and deviance residuals to check the model assumptions. The extended regression model is very useful for the analysis of real data.     

Nonparametric model checks in censored regression

Let M be a parametric model for an unknown regression function m. In order to check the validity of M, i.e., to test for m ∈ M, it is known that optinal tests should be based on the empirical process of the regressors marked by the residuals. In this paper we extend the methodology to censored regression. The asymptotic distribution of the underlying marked empirical process in provided. The Wild Bootstrap, appropriately modified to account for censhorship, provides distributional approximations. The method is applied to simulated data sets as well as tto the Stanford Heart Transplant Data.