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The fitting of age-dependent HIV incidence models to AIDS data is a computationally intensive task, particularly when allowance is made for non-proportional dependence of the infection rate on age. This paper presents a computational alternative to a very intensive method described by Rosenberg (1994). Our approach is to use the EM algorithm on a discretized form of the model used by Rosenberg (1994). The EM approach has certain attractive features including ease of implementation and flexibility. of model specification. It also conveniently generalizes to allow smoothed estimation and less detailed forms of age-specific AIDS data.  相似文献   

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Detecting the number of signals and estimating the parameters of the signals is an important problem in signal processing. Quite a number of papers appeared in the last twenty years regarding the estimation of the parameters of the sinusoidal components but not that much of attention has been given in estimating the number of terms present in a sinusoidal signal. Fuchs developed a criterion based on the perturbation analysis of the data auto correlation matrix to estimate the number of sinusoids, which is in some sense a subjective-based method. Recently Reddy and Biradar proposed two criteria based on AIC and MDL and developed an analytical framework for analyzing the performance of these criteria. In this paper we develop a method using the extended order modelling and singular value decomposition technique similar to that of Reddy and Biradar. We use penalty function technique but instead of using any fixed penalty function like AIC or MDL, a class of penalty functions satisfying some special properties has been used. We prove that any penalty function from that special class will give consistent estimate under the assumptions that the error random variables are independent and identically distributed with mean zero and finite variance. We also obtain the probabilities of wrong detection for any particular penalty function under somewhat weaker assumptions than that of Reddy and Biradar of Kaveh et al. It gives some idea to choose the proper penalty function for any particular model. Simulations are performed to verify the usefulness of the analysis and to compare our methods with the existing ones.  相似文献   

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This article reports results of an extensive simulation study which investigated the performances of some commonly used methods of estimating error rates in discriminant analysis. Earlier research papers limited their comparisons of these methods to independent training data. This study allows for a simple auto-regressive dependence among the training data. The results suggest that the estimation methods based on the normal distribution perform adequately well under conditions of negative or mild positive correlation in the data, and small dimensions (p) of the observation vectors. For large p or strong positive correlation structures the conclusion is that one of the better non-parametric methods should be used. Special circumstances and conditions which notably affect the relative performances of the methods are identified.  相似文献   

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